Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Regioselective Synthesis of 1,3,4,5-Tetrasubstituted Pyrazoles from α-Alkenyl-α,β-Enones Derived from Morita-Baylis-Hillman Adducts

  • Kim, Sung Hwan (Department of Chemistry and Institute of Basic Science, Chonnam National University) ;
  • Lim, Jin Woo (Department of Chemistry and Institute of Basic Science, Chonnam National University) ;
  • Yu, Jin (Department of Chemistry and Institute of Basic Science, Chonnam National University) ;
  • Kim, Jae Nyoung (Department of Chemistry and Institute of Basic Science, Chonnam National University)
  • Received : 2013.06.27
  • Accepted : 2013.07.08
  • Published : 2013.10.20
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Abstract

Convenient synthetic method for 4-arylethylpyrazoles and 4-styrylpyrazoles was developed using ${\alpha}$-alkenyl-${\alpha},{\beta}$-enones readily accessed from the Morita-Baylis-Hillman reaction. For the synthesis of 4-arylethylpyrazole, the reactions with arylhydrazines needed to be carried out in o-dichlorobenzene under $N_2$ balloon atmosphere. On the other hand, 4-styrylpyrazoles required the reactions in ethanol under $O_2$ balloon atmosphere.

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References

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