생약학회지 (Korean Journal of Pharmacognosy)

  • 제44권3호
  • /
  • Pages.230-234
  • /
  • 2013
  • /
  • 0253-3073(pISSN)
  • /
  • 2288-9299(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

꽃마리 지상부의 DPPH Free Radical 소거활성 성분

DPPH Free Radical Scavengers from the Aerial Part of Trigonotis peduncularis Bentham

  • 투고 : 2013.08.26
  • 심사 : 2013.09.12
  • 발행 : 2013.09.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

In the course of screening for antioxidant compounds by measuring the DPPH radical scavenging activity, a total extract of the aerial part of Trigonotis peduncularis (Boraginaceae) was found to show potent DPPH radical scavenging activity. Subsequent activity-guided fractionation of the methanolic extract of T. peduncularis led to the isolation of seven compounds, kaempferol (1), quercetin (2), trigonotin A (3), astragalin (4), trigonotin C (5), kaempferol-3-O-${\alpha}$-L-rhamnopyranosyl(1${\rightarrow}$6)-${\beta}$-D-glucopyranoside (6), and rutin (7) from the active ethyl acetate soluble fraction. Their structures were elucidated by spectroscopic studies. Among seven compounds, compounds 1, 2, 4, 6 and 7 were isolated for the first time from this plant, and compounds 2 and 7 showed the significant DPPH free radical scavenging activities.

키워드

참고문헌

  1. Yu, B. P. (1996) Aging and oxidative stress: modulation by dietary restriction. Free Radic. Biol. Med. 21: 651-668. https://doi.org/10.1016/0891-5849(96)00162-1
  2. Agrawal, S., Kulkarni, G. T. and Sharma, V. N. (2011) A comparative study on the antioxidant activity of methanolic extracts of Terminalia paniculata and Madhuca longifolia. Free Rad. Antiox. 1: 62-68.
  3. Sasikumar, J. M., Patharaj, J., Adithya, E. S., Adithya, Christabel, P. H. and Shamna, R. (2012) Antioxidant capacity and phenolic content of Elaeagnus kologa schlecht. an underexploited fruit from India. Free Rad. Antiox. 2: 28-35. https://doi.org/10.5530/ax.2012.3.4
  4. Hatipoglua, G., Sökmena, M., Bektasb, E., Dafererac, D., Sökmenb, A., Demira, E. and Sahin, H. (2013) Automated and standard extraction of antioxidant phenolic compounds of Hyssopus officinalis L. ssp. angustifolius. Ind. Crops Prod. 43: 427-433. https://doi.org/10.1016/j.indcrop.2012.07.028
  5. Si, C.-L., Shen, T., Jiang, Y.-Y., Wu, L., Yu, G.-J., Ren, X.-D., Xu, G.-H., Hu, W.-C. (2013) Antioxidant properties and neuroprotective effects of isocampneoside II on hydrogen peroxide- induced oxidative injury in PC12 cells. Food Chem. Toxicol. 59: 145-152. https://doi.org/10.1016/j.fct.2013.05.051
  6. Lee, Y. N. (2006) New flora of Korea II. 127, Kyohaksa, Seoul.
  7. Otsuka, H., Kuwabara, H. and Hoshiyama, H. (2008) Identification of sucrose diesters of Aryldihydronaphthalene-type lignans from Trigonotis peduncularis and the nature of their fluorescence. J. Nat. Prod. 71: 1178-1181. https://doi.org/10.1021/np800071r
  8. Yoshida, T., Mori, K., Hatano, T., Okumura, T., Uehara, I., Komagoe, K., Fujita, Y. and Okuda, T. (1989) Studies on inhibition mechanism of autooxidation by tannins and flavonoids. V. Radical scavenging effects of tannins and related polyphenols on 1,1-diphenyl-2-picrylhydrazyl radical. Chem. Pharm. Bull. 37: 1919-1921. https://doi.org/10.1248/cpb.37.1919
  9. Budzianowski, J. (1991) Six flavonol glucuronides from Tulipa gesneriana. Phytochemistry 30: 1679-1682. https://doi.org/10.1016/0031-9422(91)84233-I
  10. Do, J. C., Yu, Y. J., Jung, K. Y. and Son, K. H. (1992) Flavonids from the leaves of Polygala japonica. Kor. J. Pharmacogn. 23: 9-13.
  11. Han, J. T., Bang, M. H., Chun, O. K., Kim, D. O., Lee, C. Y. and Baek, N. I. (2004) Flavonol glycosides from the aerial parts of Aceriphyllum rossii and their antioxidant activities. Arch. Pharm. Res. 27: 390-395. https://doi.org/10.1007/BF02980079
  12. Park, J. C., Yu, Y. B., Lee, J. H., Choi, J. S. and Ok, K. D. (1996) Phenolic compounds from the rachis of Cedrela sinensis. Kor. J. Pharmacogn. 27: 219-223.