International Journal of Industrial Entomology and Biomaterials

Korean Society of Sericultural Science (한국잠사학회)
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The Effect of Silk Membrane Plus 3% 4-hexylresorcinol on Guided Bone Regeneration in a Rabbit Calvarial Defect Model

  • Seok, Hyun (Department of Oral and Maxillofacial surgery, College of Dentistry, Gangneung-Wonju National University) ;
  • Lee, Sang-Woon (Department of Oral and Maxillofacial surgery, College of Dentistry, Gangneung-Wonju National University) ;
  • Kim, Seong-Gon (Department of Oral and Maxillofacial surgery, College of Dentistry, Gangneung-Wonju National University) ;
  • Seo, Dong-Hyun (Department of Biomedical Engineering, Institute of Medical Engineering and Yonsei-Fraunhofer Medical, Device Laboratory, Yonsei University) ;
  • Kim, Han Sung (Department of Biomedical Engineering, Institute of Medical Engineering and Yonsei-Fraunhofer Medical, Device Laboratory, Yonsei University) ;
  • Kweon, Hae Yong (Sericultural & Apicultural Materials Division, National Academy of Agricultural Science) ;
  • Jo, You-Young (Sericultural & Apicultural Materials Division, National Academy of Agricultural Science) ;
  • Kang, Tae Yeon (Gangneung Center, Korea Basic Science Institute) ;
  • Lee, Myung-Jin (Gangneung Center, Korea Basic Science Institute) ;
  • Chae, Weon-Sik (Gangneung Center, Korea Basic Science Institute)
  • Received : 2013.09.09
  • Accepted : 2013.09.14
  • Published : 2013.09.30
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Abstract

The objective of this study was to evaluate the bone regeneration capability of silk membrane plus 3% 4-hexylresorcinol (3% 4-HR plus SM) in a rabbit calvarial defect model. Twenty New Zealand white rabbits were used in this study. Bilateral round shaped defects were created in the parietal bone (diameter: 8.0 mm). And the defects were covered with (1) 3% 4-HR plus SM, (2) collagen membrane (CM), (3) no graft material. After surgery, the animals were sacrificed at 4 weeks and 8 weeks. Bone regeneration was analyzed in each section by micro-computerized tomography (${\mu}$-CT). And Hematoxylin and eosin stains were used for histological analysis. As measured by ${\mu}$-CT analysis 4 weeks after surgery, the average of new bone formation in animals treated with 3% 4-HR plus SM was greater than that of animals treated with CM. and the difference was statistically significant. And well organized lamella bones were observed in the histological view of the 3% 4-HR plus SM group. Therefore, more bone regeneration was seen in animals treated with 3% 4-HR plus SM than in those treated with CM or uncovered control.

Keywords

References

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