Journal of Oriental Neuropsychiatry (동의신경정신과학회지)

The Korean Society of Oriental Neuropsychiatry (대한한방신경정신과학회)
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The Anxiolytic, Anti-Depressive Effects Using Bambusae Caulis in Taeniam Extract in Rat Chronic Immobilization Stress Model

구속스트레스로 불안과 우울증상을 일으킨 백서에서 죽여의 개선 효과

  • Lyu, Yun-Sun (Department of Oriental Neuropsychiatry Medicine, College of Oriental Medicine, Won-Kwang University) ;
  • Park, Jong-Min (Department of Oriental Neuropsychiatry Medicine, College of Oriental Medicine, Won-Kwang University) ;
  • Ko, In-Sung (Department of Oriental Neuropsychiatry, Dongseo Oriental Medical Center) ;
  • Kang, Hyoung-Won (Department of Oriental Neuropsychiatry Medicine, College of Oriental Medicine, Won-Kwang University) ;
  • Lyu, Yeoung-Su (Department of Oriental Neuropsychiatry Medicine, College of Oriental Medicine, Won-Kwang University)
  • 유윤선 (원광대학교 한의과대학 신경정신과학교실) ;
  • 박종민 (원광대학교 한의과대학 신경정신과학교실) ;
  • 고인성 (동서한방병원 한방신경정신과) ;
  • 강형원 (원광대학교 한의과대학 신경정신과학교실) ;
  • 유영수 (원광대학교 한의과대학 신경정신과학교실)
  • Received : 2013.08.01
  • Accepted : 2013.08.22
  • Published : 2013.09.30
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Abstract

Objectives : The Bambusae Caulis in Taeniam has been used in traditional oriental medicine to treat a variety of mental disorders including anxiety and depression. The purpose of present study is to observe the changes which take place in the body in stressful situations and to compare the anti-depressive, anxiolytic and anti-stress effect of Bambusae Caulis in Taeniam in different doses. Methods : This study was performed to evaluate the effects of Bambusae Caulis in Taeniam in the immobilization stress model in rats. Twenty-five rats were divided into 5 groups of 5: control, stress, low dose administration (75 mg/kg), medium dose administration (150 mg/kg) and high dose administration (225 mg/kg). The four groups other than the control group were placed in an immobilization stress test, and distilled water (control) or Bambusae Caulis in Taeniam extract was administration orally for 2 weeks. After treatment, the despair and anxiety behavior of rats were measured by open field test, forced swimming test, weight gain, contents of 5-HT in raphe nucleus and adrenal gland weight. Results & Conclusions : As a result of evaluation by measuring five aspects, FST, OFT, weight gain, 5-HT contents and adrenal gland weight, Bambusae Caulis in Taeniam has significant antidepressant, anxiolytic, anti-stress effects.

Keywords

References

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