한국발생생물학회지:발생과생식 (Development and Reproduction)

  • 제17권2호
  • /
  • Pages.111-119
  • /
  • 2013
  • /
  • 2465-9525(pISSN)
  • /
  • 2465-9541(eISSN)
한국발생생물학회 (The Korean Society of Developmental Biology)
권호 표지
DOI QR코드

DOI QR Code

Continuous Melatonin Attenuates the Regressing Activities of Short Photoperiod in Male Golden Hamsters

  • Choi, Donchan (Department of Life Science, College of Environmental Sciences, Yong-In University)
  • 투고 : 2013.05.23
  • 심사 : 2013.06.13
  • 발행 : 2013.06.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Golden hamsters reproduce in a limited time of a year. Their sexual activities are active in summer but inactive in winter during which day length does not exceed night time and environmental conditions are severe to them. The reproductive activities are determined by the length of light in a day (photoperiod). Melatonin is synthesized and secreted only at night time from the pineal gland. Duration of elevated melatonin is longer in winter than summer, resulting in gonadal regression. The present study aimed at the influences of continuous melatonin treatments impinging on the gonadal function in male golden hamsters. Animals received empty or melatonin-filled capsules for 10 weeks. They were divided into long photoperiod (LP) and short photoperiod (SP). All the animals maintained in LP (either empty or melatonin-filled capsules) showed large testes, implying that melatonin had no effects on testicular functions. Animals housed in SP displayed completely regressed testes. But animals kept in SP and implanted with melatonin capsules exhibited blockage of full regression by SP. These results suggest that constant release of melatonin prohibits the regressing influence of SP.

키워드

참고문헌

  1. Bliss SP, Navratil AM, Xie J, Roberson MS (2010) GnRH s ignaling, the gonadotrope and endocrine control of fertility. Neuroendocrinology 31:322-340. https://doi.org/10.1016/j.yfrne.2010.04.002
  2. Choi D (1996) Reproductive physiology of pineal hormone melatonin. Korean J Zool 39:337-351.
  3. Choi D, Lee S-H (2012) Neuroendocrine system in seasonal breeder: focusing on the reproductive activity of male golden hamster. Dev Reprod 16:1-8.
  4. Ciccone N, Dunn IC, Boswell T, Tsutsui K, Ubuka T, Ukena K, Sharp PJ (2004) Gonadotrophin-inhibitory hormone depresses gonadotrophin alpha and follicle stimulating hormone beta subunit expression in the pituitary of the domestic chicken. J Neuroendocrinol 16:999-1006. https://doi.org/10.1111/j.1365-2826.2005.01260.x
  5. de Roux N, Genin E, Carel JC, Matsuda F, Chaussain JL, Milgrom E (2003) Hypogonadotropic hypogonadism due to loss of function of the Kiss-1 derived peptide receptor GPR54. Proc Natl Acad Sci USA 100:10972- 10976. https://doi.org/10.1073/pnas.1834399100
  6. Dodge J, Badura LL (2001) Norepinephrine dialysate levels in the hypothalamic paraventricular nucleus: influence on photoperiod-driven prolactin levels in the female Siberian hamster. Neuroendocrinol 73:102-110. https://doi.org/10.1159/000054626
  7. Elliott JA (1976) Circadian rhythms and photoperiodic time measurement in mammals. Fed Pro 35:2339- 2346.
  8. Gaston S, Menaker M (1967) Photoperiodic control of hamster testis. Science 158:925-928. https://doi.org/10.1126/science.158.3803.925
  9. Grosse J, Maywood ES, Ebling FJP, Hastings MH (1993) Testicular regression in pinealectomized Syrian hamsters following infusions of melatonin delivered on noncircadian schedules. Biol Reprod 49:666-674. https://doi.org/10.1095/biolreprod49.4.666
  10. Lee SH, Choi D (2005) KiSS-1: A novel neuropeptide in mammalian reproductive system. Dev Reprod 9:1-5.
  11. Maywood ES, Lindsay JO, Karp J, Power JB, Williams LM, Titchener L, Ebling FJP, Herbert J, Hasting MH (1991) Occlusion of the melatonin-free interval blocks the short day gonadal response of the male Syrian hamster to programmed melatonin infusions of necessary duration and amplitude. J Neuroendocrinol 3:331-337. https://doi.org/10.1111/j.1365-2826.1991.tb00283.x
  12. Osugi T, Ukena K, Bentley GE, O'Brien S, Moore IT, Wingfield JC, Tsutsui K (2004) Gonadotropin-inhibitory hormone in Gambel's white-crowned sparrows: cDNA identification, transcript localization and functional effects in laboratory and field experiments. J Endocrinol 182: 33-42. https://doi.org/10.1677/joe.0.1820033
  13. Pickard GE, Silverman AJ (1979) Effects of photoperiod on hypothalamic luteinizing hormone releasing hormone in the male golden hamster. J Endocrinol 83:421-428. https://doi.org/10.1677/joe.0.0830421
  14. Reiter RJ (1980) Photoperiod: Its importance as an impeller of pineal and seasonal reproductive rhythms. Int J Biometeorol 2457-2463.
  15. Revel FG, Ansel L, Klosen P, Saboureau M, Pevet P, Mikkelsen JD, Simonneaux V (2007) Kisspeptin: a key link to seasonal breeding. Rev Endocr Metab Disord. 8:57-65. https://doi.org/10.1007/s11154-007-9031-7
  16. Revel FG, Saboureau M, Pevet P, Simonneaux V, Mikkelsen JD (2008) RFamide-related peptide gene is a melatonin driven photoperiodic gene. Endocrinology 149:902- 912. https://doi.org/10.1210/en.2007-0848
  17. Rollag MD, Stetson MH (1981) Ontogeny of the pineal melatonin rhythm in golden hamsters. Biol Reprod 24:311-314. https://doi.org/10.1095/biolreprod24.2.311
  18. Rossi SP, Matzkin ME, Terradas C, Ponzio R, Puigdomenech E, Levalle O, Calandra RS, Frungieri MB (2012) New insights into melatonin/CRH signaling in hamster Leydig cells. Gen Comp Endocrinol 178:153-163. https://doi.org/10.1016/j.ygcen.2012.04.031
  19. Stetson MH, Tay DE (1983) Time course of sensitivity of golden hamsters to melatonin injections throughout the day. Biol Reprod 29:432-438. https://doi.org/10.1095/biolreprod29.2.432
  20. Stetson MH, Watson-Whitmyre M (1984) Physiology of the pineal and its hormone melatonin in annual reproduction in rodents. In "The Pineal Gland" edited by Reiter RJ, Raven Press, New York, pp 109-153.
  21. Stetson MH, Watson-Whitmyre M (1986) Effects of exogenous and endogenous melatonin on gonadal function in hamsters. J Neural Transm 21(Suppl):55-80.
  22. Tsutsui K, Bentley GE, Ubuka T, Saigoh E, Yin H, Osugi T, Inoue K, Chowdhury VS, Ukena K, Ciccone N, Sharp PJ, Wingfield JC (2007) The general and comparative biology of gonadotropin-inhibitory hormone (GnIH). Gen Comp Endocrinol 153:365-370. https://doi.org/10.1016/j.ygcen.2006.10.005
  23. Tsutsui K, Saigoh E, Ukena K, Teranishi H, Fujisawa Y, Kikuchi M, Ishii S, Sharp PJ (2000) A novel avian hypothalamic peptide inhibiting gonadotropin release. Biochem Biophys Res Commun 275:661-667. https://doi.org/10.1006/bbrc.2000.3350
  24. Ubuka T, Bentley GE, Ukena K, Wingfield JC, Tsutsui K (2005) Melatonin induces the expression of gonadotropininhibitory hormone in the avian brain. Proc Natl Acad Sci USA 102:3052-3057. https://doi.org/10.1073/pnas.0403840102
  25. Ubuka T, Kim S, Huang Y, Reid J, Jiang J, Osugi T, Chowdhury VS, Tsutsui K, Bentley GE (2008) Gonadotropin- inhibitory hormone neurons interact directly with gonadotropin-releasing hormone-I and -II neurons in European starling brain. Endocrinology 149:268-278. https://doi.org/10.1210/en.2007-0983
  26. Ubuka T, Ukena K, Sharp PJ, Bentley GE, Tsutsui K (2006) Gonadotropin-inhibitory hormone inhibits gonadal development and maintenance by decreasing gonadotropin synthesis and release in male quail. Endocrinology 147: 1187-1194. https://doi.org/10.1210/en.2005-1178
  27. Watson-Whitmyre M, Stetson MH (1985) A mathematical method for estimating paired testes weight from in situ testicular measurements in three species of hamster. Anat Rec 213:473-476. https://doi.org/10.1002/ar.1092130313
  28. Yin H, Ukena K, Ubuka T, Tsutsui K (2005) A novel G protein-coupled receptor for gonadotropin-inhibitory hormone in the Japanese quail (Coturnix japonica): Identification, expression and binding activity. J Endocrinol 184:257-266. https://doi.org/10.1677/joe.1.05926