Journal of applied mathematics & informatics

The Korean Society for Computational and Applied Mathematics (한국전산응용수학회)
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FINITE ELEMENT MODEL TO STUDY CALCIUM DIFFUSION IN A NEURON CELL INVOLVING JRYR, JSERCA AND JLEAK

  • Yripathi, Amrita (Department of Applied Mathematics and Humanities, S. V. National Institute of Technology) ;
  • Adlakha, Neeru (Department of Applied Mathematics and Humanities, S. V. National Institute of Technology)
  • Received : 2012.11.07
  • Accepted : 2013.02.04
  • Published : 2013.09.30
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Abstract

Calcium is well known role for signal transduction in a neuron cell. Various processes and parameters modulate the intracellular calcium signaling process. A number of experimental and theoretical attempts are reported in the literature for study of calcium signaling in neuron cells. But still the role of various processes, components and parameters involved in calcium signaling is still not well understood. In this paper an attempt has been made to develop two dimensional finite element model to study calcium diffusion in neuron cells. The JRyR, JSERCA and JLeak, the exogenous buffers like EGTA and BAPTA, and diffusion coefficients have been incorporated in the model. Appropriate boundary conditions have been framed. Triangular ring elements have been employed to discretized the region. The effect of these parameters on calcium diffusion has been studied with the help of numerical results.

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References

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