Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Facile Synthetic Routes to Prepare α-Muricholic Acid, Hyocholic Acid, and Their Taurine Conjugates

  • Kang, Dong Wook (Department of Pharmaceutical Science and Technology, Catholic University of Daegu) ;
  • Luecke, Hans F. (Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health)
  • Received : 2013.03.26
  • Accepted : 2013.05.22
  • Published : 2013.08.20
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Abstract

${\alpha}$-Muricholic acid was synthesized through 9 steps from chenodeoxycholic acid with 26% overall yield. Hyocholic acid was synthesized through 8 steps from the same starting material with 63% overall yield. Taurine conjugates of ${\alpha}$-muricholic acid and hyocholic acid were also prepared via their pentafluorophenyl ester.

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References

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