Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Preparation of Bonded Cellulose Tris(3,5-dimethylphenylcarbamate) Chiral Stationary Phases by Using Three Bifunctional Reagents

  • Zhang, Yi Jun (Department of Chemistry, Graduate School, Kyungpook National University) ;
  • Huang, Mingxian (College of Chemistry and Chemical Engineering, Henan Institute of Science and Technology) ;
  • Zhang, Yuping (College of Chemistry and Chemical Engineering, Henan Institute of Science and Technology) ;
  • Ryoo, Jae Jeong (Department of Chemistry, Graduate School, Kyungpook National University)
  • Received : 2013.04.15
  • Accepted : 2013.06.07
  • Published : 2013.09.20
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Abstract

Three di-acyl chlolide reagents, adipoyl chloride, terephthaloyl chloride and isophthaloyl chloride, were used as spacer reagents to prepare bonded type of three cellulose (3,5-dimethylphenyl)carbamate (CDMPC) chiral stationary phases (CSPs). The CDMPC CSPs were prepared using these three acid chlorides as spacer agents at the 6-position of the primary hydroxyl group on the glucose unit of cellulose regioselectively. The chiral recognition ability of the prepared CSPs for five racemates was evaluated by normal-phase high-performance liquid chromatography (HPLC) with the following mobile phases: hexane/isopropanol (IPA), hexane/IPA/tetrahydrofuran (THF) and hexane/IPA/chloroform. The result showed that these prepared CSPs can be used in THF and chloroform solutions and the chiral recognition abilities of the CSPs were improved depending on the eluents and chiral samples.

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References

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