Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Synthesis of 2,2'-Dipyrryl Ketones from Pyrrole-2-carboxylic Acids with Trifluoroacetic Anhydride

  • Kim, Se Hee (Department of Chemistry and Institute of Basic Science, Chonnam National University) ;
  • Lim, Jin Woo (Department of Chemistry and Institute of Basic Science, Chonnam National University) ;
  • Yu, Jin (Department of Chemistry and Institute of Basic Science, Chonnam National University) ;
  • Kim, Jae Nyoung (Department of Chemistry and Institute of Basic Science, Chonnam National University)
  • Received : 2013.04.30
  • Accepted : 2013.06.06
  • Published : 2013.09.20
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Abstract

An efficient synthesis of 2,2'-dipyrryl ketones has been carried out from pyrrole-2-carboxylic acids using trifluoroacetic anhydride (TFAA). Simultaneous generation of both mixed anhydride and 2-unsubstituted pyrrole, via facile decarboxylation with in-situ generated TFA, made their cross reaction (intermolecular Friedel-Crafts acylation) possible and efficient.

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References

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