대한불안의학회지 (Anxiety and mood)

  • 제9권2호
  • /
  • Pages.101-105
  • /
  • 2013
  • /
  • 2586-0151(pISSN)
  • /
  • 2586-0046(eISSN)
대한불안의학회 (Korean Academy of Anxiety Disorders)
권호 표지

소아 청소년 양극성장애 환아군에서의 첫 기분 삽화의 극성에 따른 단기 예후 비교 : 단일 기관 연구

The Comparison of the Short-Term Prognosis According to the Polarity of First Episode in Children and Adolescent with Bipolar Disorder : A Single Center Study

  • 권국주 (서울대학교병원 어린이병원 소아청소년정신건강의학과) ;
  • 박수빈 (서울대학교병원 어린이병원 소아청소년정신건강의학과) ;
  • 이수민 (서울대학교병원 어린이병원 소아청소년정신건강의학과) ;
  • 김재원 (서울대학교병원 어린이병원 소아청소년정신건강의학과) ;
  • 신민섭 (서울대학교병원 어린이병원 소아청소년정신건강의학과) ;
  • 유희정 (서울대학교병원 어린이병원 소아청소년정신건강의학과) ;
  • 조수철 (서울대학교병원 어린이병원 소아청소년정신건강의학과) ;
  • 김붕년 (서울대학교병원 어린이병원 소아청소년정신건강의학과)
  • Kweon, Kukju (Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University Hospital) ;
  • Park, Subin (Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University Hospital) ;
  • Lee, Soo-Min (Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University Hospital) ;
  • Kim, Jae-Won (Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University Hospital) ;
  • Shin, Min-Sup (Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University Hospital) ;
  • Yoo, Hee-Jeong (Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University Hospital) ;
  • Cho, Soo-Churl (Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University Hospital) ;
  • Kim, Bung-Nyun (Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University Hospital)
  • 투고 : 2013.08.02
  • 심사 : 2013.09.29
  • 발행 : 2013.10.31
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Objectives : This study was conducted to evaluate the association between first episode polarity of pediatric bipolar disorder and prognosis. Methods : We analyzed the clinical records of 66 inpatient subjects with DSM-IV defined pediatric bipolar disorder. The patients were split into 2 groups according to the polarity of the illness onset [depressive onset (DO) vs. manic/hypomanic/mixed onset (MO)]. Clinical feature and prognosis were compared between the two groups of patients. Results : In our sample, 68% of patients experienced a depressive onset. In DO patients, rates of suicidal attempt, episodic illness course and comorbid disruptive behavior disorder were higher than rates in MO patients. Conclusion : Findings from this study suggest that polarity of illness onset may be useful in predicting the prognosis of pediatric bipolar disorder.

키워드

참고문헌

  1. Duffy A. Does bipolar disorder exist in children? A selected review. Canadian journal of psychiatry 2007;52:409-417. https://doi.org/10.1177/070674370705200702
  2. Lewinsohn PM, Klein DN, Seeley JR. Bipolar disorders in a community sample of older adolescents: prevalence, phenomenology, comorbidity, and course. Journal of the American Academy of Child & Adolescent Psychiatry 1995;34:454-463. https://doi.org/10.1097/00004583-199504000-00012
  3. Chengappa KN, Kupfer DJ, Frank E, Houck PR, Grochocinski VJ, Cluss PA, et al. Relationship of birth cohort and early age at onset of illness in a bipolar disorder case registry. Am J Psychiatry 2003;160: 1636-1642. https://doi.org/10.1176/appi.ajp.160.9.1636
  4. Shaw JA, Egeland JA, Endicott J, Allen CR, Hostetter AM. A 10-year prospective study of prodromal patterns for bipolar disorder among Amish youth. J Am Acad Child Adolesc Psychiatry 2005;44:1104-1111. https://doi.org/10.1097/01.chi.0000177052.26476.e5
  5. Weller RA, Weller EB, Tucker SG, Fristad MA. Mania in prepubertal children: has it been underdiagnosed? J Affect Disord 1986;11: 151-154. https://doi.org/10.1016/0165-0327(86)90022-4
  6. Lish JD, Dime-Meenan S, Whybrow PC, Price RA, Hirschfeld RM. The National Depressive and Manic-depressive Association (DM-DA) survey of bipolar members. J Affect Disord 1994;31:281-294. https://doi.org/10.1016/0165-0327(94)90104-X
  7. Joyce PR. Age of onset in bipolar affective disorder and misdiagnosis as schizophrenia. Psychol Med 1984;14:145-149. https://doi.org/10.1017/S0033291700003147
  8. Carlson GA, Fennig S, Bromet EJ. The confusion between bipolar disorder and schizophrenia in youth: where does it stand in the 1990s? J Am Acad Child Adolesc Psychiatry 1994;33:453-460. https://doi.org/10.1097/00004583-199405000-00002
  9. Akiskal HS. Dysthymic and cyclothymic depressions: therapeutic considerations. Journal of Clinical Psychiatry;1994.
  10. Caron C, Rutter M. Comorbidity in child psychopathology: concepts, issues and research strategies. J Child Psychol Psychiatry 1991;32: 1063-1080. https://doi.org/10.1111/j.1469-7610.1991.tb00350.x
  11. Kim BN, Cho SC. How can we tell the difference between bipolar disorder and attention-deficit/hyperactivity disorder? Park WM, Jon DI, et al. bipolar disorder. Seoul: Sigmapress;2009. p.423-424.
  12. Perugi G, Micheli C, Akiskal HS, Madaro D, Socci C, Quilici C, et al. Polarity of the first episode, clinical characteristics, and course of manic depressive illness: a systematic retrospective investigation of 320 bipolar I patients. Compr Psychiatry 2000;41:13-18. https://doi.org/10.1016/S0010-440X(00)90125-1
  13. Daban C, Colom F, Sanchez-Moreno J, Garcia-Amador M, Vieta E. Clinical correlates of first-episode polarity in bipolar disorder. Compr Psychiatry 2006;47:433-437. https://doi.org/10.1016/j.comppsych.2006.03.009
  14. Azorin JM, Kaladjian A, Adida M, Fakra E, Hantouche E, Lancrenon S. Correlates of first-episode polarity in a French cohort of 1089 bipolar I disorder patients: role of temperaments and triggering events. J Affect Disord 2011;129:39-46. https://doi.org/10.1016/j.jad.2010.08.020
  15. Perlis RH, Delbello MP, Miyahara S, Wisniewski SR, Sachs GS, Nierenberg AA, et al. Revisiting depressive-prone bipolar disorder: polarity of initial mood episode and disease course among bipolar I systematic treatment enhancement program for bipolar disorder par-ticipants. Biol Psychiatry 2005;58:549-553. https://doi.org/10.1016/j.biopsych.2005.07.029
  16. Forty L, Jones L, Jones I, Smith DJ, Caesar S, Fraser C, et al. Polarity at illness onset in bipolar I disorder and clinical course of illness. Bipolar Disord 2009;11:82-88. https://doi.org/10.1111/j.1399-5618.2008.00654.x
  17. Chaudhury SR, Grunebaum MF, Galfalvy HC, Burke AK, Sher L, Parsey RV, et al. Does first episode polarity predict risk for suicide attempt in bipolar disorder? J Affect Disord 2007;104:245-250. https://doi.org/10.1016/j.jad.2007.02.022
  18. Kassem L, Lopez V, Hedeker D, Steele J, Zandi P, Bipolar Disorder Consortium NGI, et al. Familiality of polarity at illness onset in bipolar affective disorder. Am J Psychiatry 2006;163:1754-1759. https://doi.org/10.1176/ajp.2006.163.10.1754
  19. Association AP. Diagnostic and statistical manual of mental disorders: DSM-IV-TR${(R)}$. American Psychiatric Pub;2000.
  20. Park K, Yoon J, Park H, Park H, Kwon J. Development of the Korean Educational Development Institute Wechsler Intelligence Scale for Children-Revised (KEDI-WISC-R), individual intelligence test for Korean children. Korean Educational Development Institute, Seoul; 1986.
  21. Conners C, Barkley R. Rating scales and checklists for child psychopharmacology. Psychopharmacology Bulletin 1985;21:809.
  22. Biederman J, Faraone SV, Chu MP, Wozniak J. Further evidence of a bidirectional overlap between juvenile mania and conduct disorder in children. Journal of the American Academy of Child & Adolescent Psychiatry 1999;38:468-476. https://doi.org/10.1097/00004583-199904000-00021
  23. Geller B, Tillman R, Bolhofner K, Zimerman B. Child bipolar I disorder: prospective continuity with adult bipolar I disorder; characteristics of second and third episodes; predictors of 8-year outcome. Archives of General Psychiatry 2008;65:1125. https://doi.org/10.1001/archpsyc.65.10.1125