Asian-Australasian Journal of Animal Sciences

Asian Australasian Association of Animal Production Societies (아세아태평양축산학회)
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The Possibility of TBC1D21 as a Candidate Gene for Teat Numbers in Pigs

  • Jin, S. (Department of Animal Science and Biotechnology, Chungnam National University) ;
  • Lee, J.B. (Department of Animal Science, Gyeongsang National University) ;
  • Kang, K. (Department of Animal Science and Biotechnology, Chungnam National University) ;
  • Yoo, C.K. (Department of Animal Science and Biotechnology, Chungnam National University) ;
  • Kim, B.M. (Department of Animal Science and Biotechnology, Chungnam National University) ;
  • Park, H.B. (Department of Animal Science and Biotechnology, Chungnam National University) ;
  • Lim, H.T. (Department of Animal Science and Biotechnology, Chungnam National University) ;
  • Cho, I.C. (Subtropical Animal Experiment Station, National Institute of Animal Science, RDA) ;
  • Maharani, D. (Faculty of Animal Science, Gadjah Mada University) ;
  • Lee, J.H. (Department of Animal Science, Gyeongsang National University)
  • Received : 2013.03.06
  • Accepted : 2013.06.24
  • Published : 2013.10.01
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Abstract

Based on a quantitative traits locus (QTL) study using a $F_2$ intercross between Landrace and Korean native pigs, a significant QTL affecting teat numbers in SSC7 was identified. The strong positional candidate gene, TBC1D21, was selected due to its biological function for epithelial mesenchymal cell development. Sequence analysis revealed six single nucleotide polymorphisms (SNPs) in the TBC1D21 gene. Among these, two SNP markers, one silent mutation (SNP01) for g.13,050A>G and one missense mutation (SNP04) for c.829A>T (S277C), were genotyped and they showed significant associations with teat number traits (p value = 6.38E-05 for SNP01 and p value = 1.06E-07 for SNP04 with total teat numbers). Further functional validation of these SNPs could give valuable information for understanding the teat number variation in pigs.

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References

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