Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Effects of Chitosan on Wound Healing in Monkeys

원숭이에서 피부 창상 치유에 대한 키토산의 효과

  • Byun, Hong-Seob (College of Veterinary Medicine, Chungnam National University) ;
  • Lee, Soo-Jin (College of Veterinary Medicine, Chungnam National University) ;
  • Lee, Jae-Il (College of Veterinary Medicine, Chungnam National University) ;
  • Kim, Moo-Kang (College of Veterinary Medicine, Chungnam National University) ;
  • Shin, Nam-Shik (College of Veterinary Medicine, Seoul National University) ;
  • Kim, Myung-Cheol (College of Veterinary Medicine, Chungnam National University)
  • 변홍섭 (충남대학교 수의과대학) ;
  • 이수진 (충남대학교 수의과대학) ;
  • 이재일 (충남대학교 수의과대학) ;
  • 김무강 (충남대학교 수의과대학) ;
  • 신남식 (서울대학교 수의과대학) ;
  • 김명철 (충남대학교 수의과대학)
  • Accepted : 2013.08.08
  • Published : 2013.08.31
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Abstract

The objective of this study was to investigate the effects of implanted chitosan applied to surgically created wound in Japanese Macaque monkeys. 4 healthy Japanese Macaque monkeys were used. A 4 cm straight skin incision was made and undermined skin ($4{\times}4cm$) over on the 2 monkeys both sides of the dorsal midline, and a 4 cm circular skin incision was made on 2 monkeys both sides of the dorsal midline. One wound (left side) was implanted 1 mg (straight incision) and daily 0.2 mg (circular incision) of cotton type chitosan and the other wounds were treated with normal saline (3 ml) in monkeys. Each straight wound was closed with two interrupted sutures of 2-0 sutures. The monkey's circular skin incision is opened. At 14 days after initial wounding, each wound was taken for histological observations in monkeys. The inflammatory cells in the chitosan group are observed less than the control group, the collagen and the fibrin in the chitosan are observed more than the control group in monkeys. So the wound healing is moderately enhanced for chitosan treatment. The fibroblasts and the capillaries increased for chitosan treatment. The treatment of chitosan in wound is to promote healing.

Keywords

References

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