동의생리병리학회지 (Journal of Physiology & Pathology in Korean Medicine)

  • 제27권4호
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  • Pages.422-430
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  • 2013
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  • 1738-7698(pISSN)
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  • 2288-2529(eISSN)
대한동의생리학회·한의병리학회 ( The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine)
권호 표지

소오침탕가감방(小烏沈湯加減方)의 산화스트레스와 serotonin 대사 과정에 미치는 영향

Effects of So-Ochim-tang-Gagam-bang on Oxidative Stress and Serotonin Metabolism in P815 Cells

  • 황지연 (대전대학교 한의과대학 신경정신과학교실) ;
  • 이상룡 (대전대학교 한의과대학 신경정신과학교실) ;
  • 정인철 (대전대학교 한의과대학 신경정신과학교실)
  • Hwang, Ji-Yeon (Department of Neuropsychiatry, College of Korean Medicine, Daejeon University) ;
  • Lee, Sang Ryong (Department of Neuropsychiatry, College of Korean Medicine, Daejeon University) ;
  • Jung, In Chul (Department of Neuropsychiatry, College of Korean Medicine, Daejeon University)
  • 투고 : 2013.05.22
  • 심사 : 2013.07.03
  • 발행 : 2013.08.25
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초록

This experiment was designed to investigate the effects of So-Oochim-tang-Gagam-bang (SOCT-G) on oxidative stress and serotonin metabolism in P815 Mast Cells The effects of SOCT-G on activity of 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging and Super Oxide Dismutase (SOD) in P815 mast cells were investigated. The effect of SOCT-G on content of serotonin in P815 mast cells was investigated. The effects of SOCT-G on expression of 5-hydroxytryptamine transporter (5-HTT), Tryptophan hydroxylase 1 (TPH-1) mRNA in P815 mast cells were investigated. The SOCT-G increased DPPH radical-scavenging activity in P815 mast cells. The SOCT-G increased SOD activity in P815 mast cells. The SOCT-G decreased the intracellular content of serotonin in P815 mast cells. The SOCT-G decreased 5-HTT and TPH-1 mRNA expression in P815 mast cells. This experiment shows that So-Ochm-Tang-Gagam-bang has a significant effect of oxidative stress that help prevent free radical damage. And So-Ochim-Tang-Gagam-bang decreased the intracellular content of serotonin and mRNA expression of 5-HTT and TPH-1. Therefore, further researches are suggested to reveal the anti-depressive effectiveness of So-Ochim-Tang-Gagam-bang.

키워드

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