전이성 뇌암으로 오인된 노카디아 뇌농양: 적극적 치료를 요하는 심각한 중추신경계 감염병

Nocardia Brain Abscess Mimicking a Metastatic Brain Tumor: A Severe CNS Infection Requiring Aggressive Management

  • 이아름 (서울대학교병원 영상의학과) ;
  • 김희경 (순천향대학교병원 병리과)
  • Lee, Aleum (Department of Radiology, Seoul National University Hospital) ;
  • Kim, Hee Kyung (Department of Pathology, Soonchunhyang University Hospital)
  • 투고 : 2012.10.04
  • 심사 : 2013.02.19
  • 발행 : 2013.04.30

초록

노카디아병 (nocardiosis)은 actinomycetales 목, nocardia 과에 속하는 호기성 양성 간균에 의한 감염으로 노카디아종은 사람과 동물에서 국소적, 전신적인 화농성 질환을 일으킬 수 있다. 노카디아병은 일반적으로 기회감염으로 생기지만 감염자의 1/3은 면역기능이 정상이다. 저자들은 고령의 크론병 (Crohn's disease) 여자 환자에서 노카디아종에 의해 발생한 폐 노카디아병과 뇌농양의 증례를 보고하고자 한다. 이 병변은 영상 검사상 주위 부종을 동반하며 조영 증강을 보여 수술 전에는 종양으로 생각되었고, 전이성 뇌암처럼 공격적인 병의 진행을 보였다. 노카디아병의 조기 진단, 기저 질환이 없는 경우, 적절한 항생제 치료가 이루어 졌을 때 예후가 좋다. 저자들은 뇌에 생긴 노카디아병을 보고하여 자기공명영상과 컴퓨터 단층촬영 소견을 알리고 악성 병변과의 감별에 도움이 되고자 한다.

Nocardiosis is an uncommon Gram-positive bacterial infection caused by aerobic actinomycetes in the genus Nocardia. Nocardia spp. have the ability to cause localized or systemic suppurative disease in humans and animals. Nocardiosis is typically regarded as an opportunistic infection, but approximately one-third of infected patients are immunocompetent. We report a rare case of pulmonary nocardiosis and a brain abscess caused by Nocardia asteroides in an elderly woman with a history of Crohn's disease. Radiographic imaging revealed a contrast-enhancing lesion with perilesional parenchymal edema that was preoperatively thought to be a neoplasm. The patient experienced aggressive disease progression simulating a metastatic brain tumor. Early diagnosis of norcadiosis, the absence of underlying disease, and the administration of appropriate antibiotics has a positive impact on prognosis. Familiarity with the magnetic resonance and computed tomography findings associated with CNS nocardiosis, such as those presented here, is essential for making an early diagnosis.

키워드

참고문헌

  1. Beaman BL, Beaman L. Nocardia species: host-parasite relationships. Clin Microbiol Rev 1994;7:213-264
  2. Lee GY. Daniel RT, Brophy BP, Reilly PL. Surgical treatment of nocardial brain abscesses. Neurosurgery 2002;51:668-671; discussion 671-2. https://doi.org/10.1227/00006123-200209000-00010
  3. Beaman BL, Burnside J, Edwards B, Causey W. Nocardial infections in the United States, 1972-1974. J Infect Dis 1976; 134:286-289 https://doi.org/10.1093/infdis/134.3.286
  4. Mamelak AN, Obana WG, Flaherty JF, Rosenblum ML. Nocardial brain abscess: treatment strategies and factors influencing outcome. Neurosurgery 1994;35:622-631 https://doi.org/10.1227/00006123-199410000-00007
  5. Fleetwood IG, Embil JM, Ross IB. Nocardia asteroides cerebral abscess in immunocompetent hosts: report of three cases and review of surgical recommendations. Surg Neurol 2000;53:605- 610 https://doi.org/10.1016/S0090-3019(00)00242-1
  6. Mogilner A, Jallo GI, Zagzag D, Kelly PJ. Nocardia abscess of the choroid plexus: clinical and pathological case report. Neurosurgery 1998;43:949-952 https://doi.org/10.1097/00006123-199810000-00130
  7. Roquer J, Pou A, Herraiz J, et al. Primary cerebral abscess due to nocardia presenting as 'ghost tumor'. Clinical and pathological study. Eur Neurol 1990;30:254-257 https://doi.org/10.1159/000117357
  8. Lim JH, Chung TS, Kim HK, Ahn JY, Suh SH. Isolated aspergillosis of the brain in an immunocompetent patient: a case report. JKSMRM 2010;14:64-68
  9. Baikie AG, Macdonald CB, Mundy GR. Systemic nocardiosis treated with trimethoprim and sulphamethoxazole. Lancet 1970;2:261