Investigative Magnetic Resonance Imaging

Korean Society of Magnetic Resonance in Medicine (대한자기공명의과학회)
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Evaluation of Renal Oxygenation in Normal Korean Volunteers Using 3.0 T Blood Oxygen Level-Dependent MRI

3.0 T 혈중산소치의존 자기공명영상을 이용한 정상한국인에서의 신장 산소공급의 평가

  • Hwang, Sung Il (Department of Radiology, Seoul National University Bundang Hospital) ;
  • Lee, Hak Jong (Department of Radiology, Seoul National University Bundang Hospital) ;
  • Chin, Ho Jun (Department of Internal Medicine, Seoul National University Bundang Hospital) ;
  • Chae, Dong-Wan (Department of Internal Medicine, Seoul National University Bundang Hospital) ;
  • Na, Ki Young (Department of Internal Medicine, Seoul National University Bundang Hospital)
  • Received : 2012.10.25
  • Accepted : 2013.01.30
  • Published : 2013.04.30
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Abstract

Purpose : Renal blood oxygen level-dependent (BOLD) MRI has been used in the evaluation of renal oxygenation. We tried to provide the normal $R2^*$ value of the human kidney with 3.0 T, and evaluated the differences in $R2^*$ values according to gender and location. Materials and Methods: Twenty-four healthy volunteers underwent BOLD MRI at 3.0 T. Multi gradient echo-echo planar imaging sequence with seventeen echoes was used. After generation of the $T2^*$ map, the $R2^*$ was calculated. The statistical differences in $R2^*$ values between the cortex and medulla, males and females, and the right and left kidney were analyzed. The regional differences of $R2^*$ within the both kidneys were evaluated respectively. Results: BOLD MRI was successful in all participants. No gross artifact interfered with $R2^*$ measurement. The mean $R2^*$ at 3.0 T was $17.1{\pm}2.60s^{-1}$ in the cortex and $27.7{\pm}4.83s^{-1}$ in the medulla (p < 0.001). The $R2^*$ value in the medulla was significantly higher in the male than female volunteers (p = 0.025). There were no statistical differences of $R2^*$ according to the side and location in the kidney (p = 0.197). Conclusion: Renal BOLD MRI can be efficiently performed with 3.0 T MRI. Renal medullary hypoxia is present in normal volunteers. Our results may be used as reference values in the evaluation of pathologic conditions using BOLD MRI.

목적: 신장 혈중산소치의존 자기공명영상은 신장 산소공급의 평가로 사용되고 있다. 3T 자기공명영상에서 신장의 정상 $R2^*$ 값을 재고, 성별과 위치에 따른 $R2^*$ 값의 차이를 평가하고자 하였다. 대상과 방법: 24명의 건강한 자원자를 대상으로 3.0T 에서 혈중산소치의존 자기공명영상을 시행하였다. $T2^*$ 맵을 생성한 다음에 $R2^*$ 값을 계산하였고, 신피질과 신수질, 남녀 그리고 좌우 신장에 대한 $R2^*$값의 통계적 차이를 평가하였다. 양측 신장 내에서도 위치에 따른 $R2^*$값의 차이도 평가하였다. 결과: 모든 대상에서 혈중산소치의존 자기공명영상은 성공적이었으며, $R2^*$의 측정에 방해되는 인공물은 없었다. 3.0T에서의 평균 $R2^*$는 피질에서 $17.1{\pm}2.60s^{-1}$ 였으며 수질에서는 $27.7{\pm}4.83s^{-1}$ 였다 (p < 0.001). 남자의 수질의 $R2^*$ 값이 여자보다 통계적으로 유의하게 높았으나 (p=0.025), 좌우신이나 신장 내에서의 $R2^*$값의 통계적 차이는 없었다 (p=0.197). 결론: 3.0T에서 신장 혈중산소치의존 자기공명영상은 효과적으로 시행될 수 있었다. 정상인에서 상대적인 신수질의 저산소증이 존재하였고, 이 결과는 병리적인 환경에서 신장 평가에서의 기준치로 사용될 수 있을 것으로 생각된다.

Keywords

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