Clinical and Experimental Reproductive Medicine

The Korean Society for Reproductive Medicine (대한생식의학회)
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Association between serum anti-M$\ddot{u}$llerian hormone level and ovarian response to mild stimulation in normoovulatory women and anovulatory women with polycystic ovary syndrome

  • Kim, Ju Yeong (Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital) ;
  • Yi, Gwang (Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital) ;
  • Kim, Yeo Rang (Department of Obstetrics and Gynecology, Seoul National University Hospital) ;
  • Chung, Jae Yeon (Department of Obstetrics and Gynecology, Seoul National University Hospital) ;
  • Ahn, Ji Hyun (Department of Obstetrics and Gynecology, Seoul National University Hospital) ;
  • Uhm, You Kyoung (Department of Obstetrics and Gynecology, Seoul National University Hospital) ;
  • Jee, Byung Chul (Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital) ;
  • Suh, Chang Suk (Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital) ;
  • Kim, Seok Hyun (Department of Obstetrics and Gynecology, Seoul National University Hospital)
  • Received : 2013.04.11
  • Accepted : 2013.06.03
  • Published : 2013.06.30
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Abstract

Objective: To evaluate the correlation between serum levels of anti-M$\ddot{u}$llerian hormone (AMH) and ovarian response to mild stimulation in normoovulatory women and anovulatory women with polycystic ovary syndrome (PCOS). Methods: Seventy-four cycles of mild stimulation (clomiphene citrate+gonadotropin followed by timed intercourse or intrauterine insemination) performed in normoovulatory women (57 cycles) and anovulatory women with PCOS (17 cycles). Ovarian sensitivity was defined by the number of mature follicles (${\geq}14mm$) on triggering day per 100 IU of gonadotropin. A correlation between ovarian sensitivity and the baseline serum AMH level (absolute or multiples of the median [MoM] value for each corresponding age) was calculated. Correlation between ovarian response and serum AMH level was evaluated. Results: Ovarian sensitivity to mild stimulation was positively correlated with absolute serum AMH (r=0.535, p<0.001) or AMH-MoM value (r=0.390, p=0.003) in normoovulatory women, but this correlation was not observed in anovulatory women with PCOS (r=0.105, p>0.05, r=-0.265, p>0.05, respectively). Conclusion: Ovarian response to mild stimulation is possibly predicted by the serum AMH level in normoovulatory women, but not in anovulatory women with PCOS.

Keywords

References

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