Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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Psychiatric Implication for the Regulation of AMPA Receptor

AMPA 수용체의 조절이 지니는 정신과적 의의

  • Oh, Daeyoung (Center for Synaptic Brain Dysfunctions, Institute of Basic Science (IBS)) ;
  • Lee, Eunee (Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST))
  • 오대영 (기초과학연구원 시냅스 뇌질환 연구단) ;
  • 이은이 (한국과학기술원 의과학대학원)
  • Received : 2013.01.30
  • Accepted : 2013.02.12
  • Published : 2013.02.28
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Abstract

Glutamate receptors are important components of synaptic transmission in the nervous system. Especially, ${\alpha}$-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors mediate most abundant excitatory synaptic transmission in the brain. There is elaborate mechanism of regulation of AMPA receptors including protein synthesis/degradation, intracellular trafficking, exocytosis/endocytosis and protein modification. In recent studies, it is revealed that functional dysregulation of AMPA receptors are related to major psychiatric disorders. In this review, we describe the structure and function of AMPA receptors in the synapse. We will introduce three steps of mechanism involving trafficking of AMPA receptors to neuronal membrane, lateral diffusion into synapses and synaptic retention by membrane proteins and postsynaptic scaffold proteins. Lastly, we will describe recent studies showing that regulation of AMPA receptors is important pathophysiological mechanism in psychiatric disorders.

Keywords

References

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