Nutrition Research and Practice

The Korean Nutrition Society (한국영양학회)
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Anti-obesity effects of hot water extract from Wasabi (Wasabia japonica Matsum.) leaves in mice fed high-fat diets

  • Yamasaki, Masayuki (Department of Environmental and Preventive Medicine, Shimane University School of Medicine) ;
  • Ogawa, Tetsuro (Shimane Institute for Industrial Technology) ;
  • Wang, Li (Department of Environmental and Preventive Medicine, Shimane University School of Medicine) ;
  • Katsube, Takuya (Shimane Institute for Industrial Technology) ;
  • Yamasaki, Yukikazu (Shimane Institute for Industrial Technology) ;
  • Sun, Xufeng (Department of Environmental and Preventive Medicine, Shimane University School of Medicine) ;
  • Shiwaku, Kuninori (Department of Environmental and Preventive Medicine, Shimane University School of Medicine)
  • Received : 2013.01.04
  • Accepted : 2013.03.29
  • Published : 2013.08.01
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Abstract

The anti-obesity effects of a hot water extract from wasabi (Wasabia japonica Matsum.) leaves (WLE), without its specific pungent constituents, such as allyl-isothiocyanate, were investigated in high fat-diet induced mice. C57J/BL mice were fed a high-fat diet (control group) or a high-fat diet supplemented with 5% WLE (WLE group). Physical parameters and blood profiles were determined. Gene expression associated with lipid metabolism in liver and white adipose tissue were analyzed. After 120 days of feeding, significantly lower body weight gain, liver weight and epididymal white adipose tissue weight was observed in the WLE group compared to the control group. In liver gene expression within the WLE group, PPAR${\alpha}$ was significantly enhanced and SREBP-1c was significantly suppressed. Subsequent downstream genes controlled by these regulators were significantly suppressed. In epididymal white adipose tissue of the WLE group, expression of leptin, PPAR${\gamma}$, and C/EBP${\alpha}$ were significantly suppressed and adiponectin was significantly enhanced. Acox, related to fatty acid oxidization in adipocytes, was also enhanced. Our results demonstrate that the WLE dietary supplement induces mild suppression of obesity in a high-fat diet induced mice, possibly due to suppression of lipid accumulation in liver and white adipose tissue.

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