Biomolecules & Therapeutics

  • 제21권4호
  • /
  • Pages.307-312
  • /
  • 2013
  • /
  • 1976-9148(pISSN)
  • /
  • 2005-4483(eISSN)
한국응용약물학회 (The Korean Society of Applied Pharmacology)
권호 표지
DOI QR코드

DOI QR Code

Dependence Potential of Quetiapine: Behavioral Pharmacology in Rodents

  • Cha, Hye Jin (Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety) ;
  • Lee, Hyun-A (Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety) ;
  • Ahn, Joon-Ik (Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety) ;
  • Jeon, Seol-Hee (Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety) ;
  • Kim, Eun Jung (Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety) ;
  • Jeong, Ho-Sang (Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety)
  • 투고 : 2013.04.19
  • 심사 : 2013.07.15
  • 발행 : 2013.07.31
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Quetiapine is an atypical or second-generation antipsychotic agent and has been a subject of a series of case report and suggested to have the potential for misuse or abuse. However, it is not a controlled substance and is not generally considered addictive. In this study, we examined quetiapine's dependence potential and abuse liability through animal behavioral tests using rodents to study the mechanism of quetiapine. Molecular biology techniques were also used to find out the action mechanisms of the drug. In the animal behavioral tests, quetiapine did not show any positive effect on the experimental animals in the climbing, jumping, and conditioned place preference tests. However, in the head twitch and self-administration tests, the experimental animals showed significant positive responses. In addition, the action mechanism of quetiapine was found being related to dopamine and serotonin release. These results demonstrate that quetiapine affects the neurological systems related to abuse liability and has the potential to lead psychological dependence, as well.

키워드

참고문헌

  1. Acheson, S. K., Richardson, R. and Swarzwelder, H. S. (1999) Developmental changes in seizure susceptibility during ethanol withdrawal. Alcohol 18, 23-26. https://doi.org/10.1016/S0741-8329(98)00063-9
  2. Adityanjee and Schulz, S. C. (2002) Clinical use of quetiapine in disease states other than schizophrenia. J. Clin. Psychiatry 63, 32-38.
  3. Arango, C. and Bobes, J. (2004) Managing acute exacerbations of schizophrenia: focus on quetiapine. Curr. Med. Res. Opin. 20, 619-626. https://doi.org/10.1185/030079904125003430
  4. Bozarth, M. A. (1987) Conditioned place preference: a parametric analysis using system heroin injection. In Methods of assessing the reinforcing properties of abused drugs (M. A. Bozarth, Ed.), pp. 241-273. Springer, New York.
  5. Brown, E. S., Nejtek, V. A., Perantie, D. C. and Bobadilla, L. (2002) Quetiapine in bipolar disorder and cocaine dependence. Bipolar Disord. 4, 406-411. https://doi.org/10.1034/j.1399-5618.2002.02229.x
  6. Chung, C. S., Wang, J., Wehman, M. and Rhoads, D. E. (2008) Severity of alcohol withdrawal symptoms depends on developmental stage of Long-Evans rats. Pharmacol. Biochem. Behav. 89, 137-144. https://doi.org/10.1016/j.pbb.2007.12.002
  7. Cohrs, S., Rodenbeck, A., Guan, Z., Pohlmann, K., Jordan, W., Meier, A. and Ruther, E. (2004) Sleep promoting properties of quetiapine in healthy subjects. Psychopharmacology 174, 421-429.
  8. Doremus, T. L., Brunell, S. C., Varlinskaya, E. L. and Spear, L. P. (2003) Anxiogenic effects during withdrawal from acute ethanol in adolescent and adult rats. Pharmacol. Biochem. Behav. 75, 411-418. https://doi.org/10.1016/S0091-3057(03)00134-5
  9. El-Kadi, A. O. and Sharif, S. I. (1994) The infl uence of various experimental conditions on the expression of naloxone-induced withdrawal symptoms in mice. Gen. Pharmacol. 25, 1505-1510. https://doi.org/10.1016/0306-3623(94)90181-3
  10. Erdogan, S. (2010) Quetiapine in substance use disorders, abuse and dependence possibility: a review. Turk. Psikiyatri Derg. 21, 167-175.
  11. Goldstein, J. M. (1999) Quetiapine fumarate (Seroquel): a new atypical antipsychotic. Drugs Today 35, 193-210. https://doi.org/10.1358/dot.1999.35.3.533849
  12. Gorelick, D. A., Gardner, E. L. and Xi, Z. X. (2004) Agents in development for the management of cocaine abuse. Drugs 64, 1547-1573. https://doi.org/10.2165/00003495-200464140-00004
  13. Hussain, M. Z., Waheed, W. and Hussain, S. (2005) Intravenous quetiapine abuse (letter). Am. J. Psychiatry 162, 1755-1756. https://doi.org/10.1176/appi.ajp.162.9.1755
  14. Kapur, S., Zipursky, R., Jones, C., Shammi, C. S., Remington, G. and Seeman, P. (2000) A positron emission tomography study of quetiapine in schizophrenia. Arch. Gen. Psychiatry 57, 553-559. https://doi.org/10.1001/archpsyc.57.6.553
  15. Kest, B., Palmese, C. A., Hopkins, E., Adler, M. and Juni, A. (2001) Assessment of acute and chronic morphine dependence in male and female mice. Pharmacol. Biochem. Behav. 70, 149-156. https://doi.org/10.1016/S0091-3057(01)00600-1
  16. Koob, G. F. (1999) Drug addiction: the yin and yang of hedonic homeostasis. Neuron 16, 893-896.
  17. Koob, G. F. (1992) Drugs of abuse: anatomy, pharmacology and function of reward pathways. Trends Pharmacol. Sci. 13, 177-184. https://doi.org/10.1016/0165-6147(92)90060-J
  18. Koob, G. and Kreek, M. J. (2007) Stress, dysregulation of drug reward pathways, and the transition to drug dependence. Am. J. Psychiatry 164, 1149-1159. https://doi.org/10.1176/appi.ajp.2007.05030503
  19. Koob, G. F., Maldonado, R. and Stinus, L. (1992) Neural substrates of opiate withdrawal. Trends Neurosci. 15, 186-191. https://doi.org/10.1016/0166-2236(92)90171-4
  20. Landry, M. J., Smith, D. E., McDuff, D. R. and Baghman, O. L. (1992) Benzodiazepine dependence and withdrawal: identifi cation and medical management. J. Am. Board Fam. Pract. 5, 167-175.
  21. Monnelly, E. P., Ciraulo, D. A., Knapp, C., LoCastro, J. and Sepulvedal (2004) Quetiapine for treatment of alcohol dependence. J. Clin. Psychopharmacol. 24, 532-535. https://doi.org/10.1097/01.jcp.0000138763.23482.2a
  22. Morin, A. K. (2007) Possible intranasal quetiapine misuse. Am. J. Health Syst. Pharm. 64, 723-725. https://doi.org/10.2146/ajhp060226
  23. Morris, S. A., Kelso, M. L., Liput, D. J., Mrshall, K. and Nixon, K. (2010) Similar withdrawal severity in adolescents and adults in a rat model of alcohol dependence. Alcohol 44, 89-98. https://doi.org/10.1016/j.alcohol.2009.10.017
  24. Mucha, R. F., van der Kooy, D., O'Shaughnessy, M. and Bucenieks, P. (1982) Drug reinforcement studied by the use of place conditioning in rat. Brain Res. 243, 91-105. https://doi.org/10.1016/0006-8993(82)91123-4
  25. Narita, M., Akai, H., Nagumo, Y., Sunagawa, N., Hasebe, K., Nagase, H., Kita, T., Hara, C. and Suzuki, T. (2004) Implications of protein kinase C in the nucleus accumbens in the development of sensitization to methamphetamine in rats. Neuroscience 127, 941-948. https://doi.org/10.1016/j.neuroscience.2004.06.017
  26. Pae, C. U., Sohi, M. S., Seo, H. J., Serretti, A., Patker, A. A., Steffens, D. C. and Masand, P. S. (2010) Quetiapine XR: current status for the treatment of major depressive disorder. Prog. Neuropsychopharmacol. Biol. Psychiatry 34, 1165-1173. https://doi.org/10.1016/j.pnpbp.2010.03.023
  27. Pierre, J. M., Shnayder, I., Wirshing, D. A. and Wirshing, W. C. (2004) Intranasal quetiapine abuse (letter). Am. J. Psychiatry 161, 1718. https://doi.org/10.1176/appi.ajp.161.9.1718
  28. Pinkofsky, H. B., Hahn, A. M., Campbell, F. A., Fueda, J., Daley, D. C. and Doualihy, A. B. (2005) Reduction of opioid-withdrawal symptoms with quetiapine. J. Clin. Psychiatry 66, 1285-1288. https://doi.org/10.4088/JCP.v66n1011
  29. Pinta, E. R. (2007) Quetiapine addiction? Am. J. Psychiatry 164, 174-175. https://doi.org/10.1176/appi.ajp.164.1.174
  30. Quetiapine fumarate. (2007) Food and Drug Administration: Electronic Orange Book. http://www.accessdata.fda.gov/scripts/cder/ob/default.cfm.
  31. Ritzmann, R. F. (1981) Opiate dependence following acute injections of morphine and naloxone: the assessment of various withdrawal signs. Pharmacol. Biochem. Behav. 14, 575-577. https://doi.org/10.1016/0091-3057(81)90320-8
  32. Saelens, J. K., Granat, F. R. and Sawyer, W. K. (1971) The mouse jumping test - a simple screening method to estimate the physical dependence capacity of analgesics. Arch. Int. Pharmacol. Ther. 190, 213-218.
  33. Sansone, R. A. and Sansone, L. A. (2010) Is seroquel developing an illicit reputation for misuse/abuse? Psychiatry 7, 13-16.
  34. Sattar, S. P., Bhatia, S. C. and Petty, F. (2004) Potential benefi ts of quetiapine in the treatment of substance dependence disorders. J. Psychiatry Neurosci. 29, 452-457.
  35. Smits, S. E. (1975) Quantitation of physical dependence in mice by naloxone-precipitated jumping after a single dose of morphine. Res. Commun. Chem. Pathol. Pharmacol. 10, 651-661.
  36. Sumegi, A. (2008) Quetiapine in bipolar disorders. Neuropsychopharmacol. Hung. 10, 281-291.
  37. Tauscher, J., Hussain, T., Agid, O., Verhoeff, N. P., Wilson, A. A., Houle, S., Remington, G., Zipursky, R. B. and Kapur, S. (2004) Equivalent occupancy of dopamine D1 and D2 receptors with clozapine: differentiation from other atypical antipsychotics. Am. J. Psychiatry 161, 1620-1625. https://doi.org/10.1176/appi.ajp.161.9.1620
  38. Taylor, C. Z. (2002) Religious addiction: obsession with spirituality. Pastoral Psychol. 50, 291-315. https://doi.org/10.1023/A:1014074130084
  39. Varlinskaya, E. I. and Spear, L. P. (2002) Acute effects of ethanol on social behavior of adolescent and adult rats: role of familiarity of the test situation. Alcohol Clin. Exp. Res. 26, 1502-1511. https://doi.org/10.1111/j.1530-0277.2002.tb02449.x
  40. Way, E. L., Loh, H. H. and Shen, F. H. (1969) Simultaneous quantitative assessment of morphine tolerance and physical dependence. J. Pharmacol. Exp. Ther. 167, 1-8.
  41. Weeks, J. R. (1972) Long term intraveneous infusion. In Methods in psychology (4th ed.) (R. D. Myers, Ed.), pp. 155-168. Academic press, New York.
  42. Weisnam, R. L. (2003) Quetiapine in the successful treatment of schizophrenia with comorbid alcohol and drug dependence: a case report. Int. J. Psychiatry Med. 33, 85-89. https://doi.org/10.2190/WM5V-D9Y2-2HYW-VGWX

피인용 문헌

  1. Use of Quetiapine in Children and Adolescents vol.17, pp.2, 2015, https://doi.org/10.1007/s40272-015-0119-3
  2. Phentermine induces conditioned rewarding effects via activation of the PI3K/Akt signaling pathway in the nucleus accumbens vol.233, pp.8, 2016, https://doi.org/10.1007/s00213-016-4231-z
  3. Evaluation of the Reinforcing Effect of Quetiapine, Alone and in Combination with Cocaine, in Rhesus Monkeys vol.356, pp.2, 2016, https://doi.org/10.1124/jpet.115.228577
  4. A case of dose escalation of quetiapine in persistent insomnia disorder vol.72, pp.5, 2017, https://doi.org/10.1080/17843286.2016.1252546
  5. Is There a Potential of Misuse for Quetiapine? pp.0271-0749, 2017, https://doi.org/10.1097/JCP.0000000000000814
  6. Abuse of Prescription Drugs in the Context of Novel Psychoactive Substances (NPS): A Systematic Review vol.8, pp.4, 2018, https://doi.org/10.3390/brainsci8040073
  7. Quetiapine-Induced Place Preference in Mice: Possible Dopaminergic Pathway vol.14, pp.2, 2013, https://doi.org/10.3390/ph14020156