Journal of the Korean Vacuum Society (한국진공학회지)

The Korean Vacuum Society (한국진공학회)
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Fabrication of TiO2 Nanowires Using Vapor-Liquid-Solid Process for the Osseointegration

골융합을 위한 Vapor-Liquid-Solid 법을 이용한 TiO2 나노와이어의 합성

  • Yun, Young-Sik (School of Integrated Technology, Yonsei University) ;
  • Kang, Eun-Hye (Department of Plastic & Reconstructive Surgery, College of Medicine, Yonsei University) ;
  • Yun, In-Sik (Department of Plastic & Reconstructive Surgery, College of Medicine, Yonsei University) ;
  • Kim, Yong-Oock (Department of Plastic & Reconstructive Surgery, College of Medicine, Yonsei University) ;
  • Yeo, Jong-Souk (School of Integrated Technology, Yonsei University)
  • 윤영식 (연세대학교 글로벌융합공학부) ;
  • 강은혜 (연세대학교 의과대학 성형외과학교실) ;
  • 윤인식 (연세대학교 의과대학 성형외과학교실) ;
  • 김용욱 (연세대학교 의과대학 성형외과학교실) ;
  • 여종석 (연세대학교 글로벌융합공학부)
  • Received : 2013.06.13
  • Accepted : 2013.07.08
  • Published : 2013.07.30
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Abstract

In order to improve osseointegration for biomedical implants, it is crucial to understand the interactions between nanostructured surfaces and cells. In this study, $TiO_2$ nanowires were prepared via Vapor-Liquid-Solid (VLS) process with Sn as a metal catalyst in the tube furnace. Nanowires were grown with $N_2$ heat treatment with their size controlled by the agglomeration of Sn layers in various thicknesses. MC3T3-E1 (pre-osteoblast) were cultured on the $TiO_2$ nanowires for a week. Preliminary results of the cell culture showed that the cells adhere well on the $TiO_2$ nanowires.

임플란트와의 골융합을 향상시키기 위해서 세포와 임플란트 표면의 나노구조의 상호작용에 대한 이해가 중요하다. 본 연구에서는 Sn를 촉매로 이용하여 Vapor-Liquid-Solid 법을 이용하여 $TiO_2$ 나노와이어를 튜브 전기로 안에서 질소기체 조건하에서 합성하였다. 이 때 촉매로 사용된 Sn 박막의 두께에 따라 응집된 나노스피어를 이용하여 $TiO_2$ 나노와이어의 크기를 조절하였다. 골융합을 위한 예비 실험으로써, 만들어진 $TiO_2$ 나노와이어 샘플 위에서 조골전구세포(pre-osteoblast)를 1주일간 배양하였고, 세포가 $TiO_2$ 나노와이어에 잘 결합함을 볼 수 있었다.

Keywords

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