Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
권호 표지
DOI QR코드

DOI QR Code

Positive Association Between miR-499A>G and Hepatocellular Carcinoma Risk in a Chinese Population

  • Zou, Hong-Zhi (Tumor Hospital Affiliated to Zhengzhou University) ;
  • Zhao, Yan-Qiu (Tumor Hospital Affiliated to Zhengzhou University)
  • Published : 2013.03.30
Download PDF
⟨ Previous Next ⟩

Abstract

A case-control study of the association of miR-499A>G rs3746444 with risk of hepatocellular carcinoma (HCC)was conducted. Patients with HCC and healthy control subjects were recruited for genotyping of miR-499A>G using duplex polymerase-chain-reaction with confronting-two-pair primer(PCR-RFLP) analysis. The MiR-499 GG genotype was associated with a decreased risk of HCC as compared with the miR-499 AA genotype (adjusted OR=0.74, 95%CI=0.24-0.96). Similarly, the GG genotype showed a 0.45-fold decreased HCC risk in a recessive model. The MiR-499 G allele was significantly associated with decreased risk of HCC among patients infected with HBV in a dominant model (OR=0.09, 95%CI= 0.02-0.29). In conclusion, the MiR-499A>G rs3746444 polymorphism is associated with HCC risk in the Chinese population, and may be useful predictive marker for CAD susceptibility.

Keywords

References

  1. Akkiz H, Bayram S, Bekar A, et al (2011). A functional polymorphism in pre-microRNA-196a-2 contributes to the susceptibility of hepatocellular carcinoma in a Turkish population: a case-control study. J Viral Hepat, 18, e399-407. https://doi.org/10.1111/j.1365-2893.2010.01414.x
  2. Akkiz H, Bayram S, Bekar A, et al (2011). Genetic variation in the microRNA-499 gene and hepatocellular carcinoma risk in a Turkish population: lack of any association in a case–control study. Asian Pac J Cancer Prev, 12, 3107-12.
  3. Aumiller V, Forstemann K (2008). Roles of microRNAs beyond development– metabolism and neural plasticity. Biochim Biophys Acta, 1779, 692-6. https://doi.org/10.1016/j.bbagrm.2008.04.008
  4. Bartel DP (2004). MicroRNAs: genomics, biogenesis, mechanism, and function. Cell, 116, 281-97. https://doi.org/10.1016/S0092-8674(04)00045-5
  5. Dimmeler S, Nicotera P (2013). MicroRNAs in age-related diseases. EMBO Mol Med, 5, 180-90. https://doi.org/10.1002/emmm.201201986
  6. El Serag HB (2011). Hepatocellular carcinoma. N Engl J Med, 365, 1118-27. https://doi.org/10.1056/NEJMra1001683
  7. Gao LB, Bai P, Pan XM, et al (2011). The association between two polymorphisms in pre-miRNAs and breast cancer risk: a meta-analysis. Breast Cancer Res Treat, 125, 571–4. https://doi.org/10.1007/s10549-010-0993-x
  8. Hu Z, Liang J, Wang Z, et al (2009). Common genetic variants in pre-microRNAs were as-sociated with increased risk of breast cancer in Chinese women. Hum Mutat, 30, 79-84. https://doi.org/10.1002/humu.20837
  9. International Agency for Research on Cancer. Liver cancer incidence and mortality worldwide in 2011; http://globocan.iarc.fr/factsheets/cancers/liver.asp. 2008.
  10. Johnnidis JB, Harris MH, Wheeler RT, et al (2008). Regulation of progenitor cell proliferation and granulocyte function by microRNA-223. Nature, 451, 1125-9. https://doi.org/10.1038/nature06607
  11. Kloosterman WP, Plasterk RH (2006). The diverse functions of microRNAs in animal development and disease. Dev Cell, 11, 441-50. https://doi.org/10.1016/j.devcel.2006.09.009
  12. Liu Z, Li G, Wei S, et al (2010). Genetic variants in selected pre microRNA genes and the risk of squamous cell carcinoma of the head and neck. Cancer, 116, 4753-60. https://doi.org/10.1002/cncr.25323
  13. Lu X, Zhao P, Zhang C, Fu Z, et al (2009). Analysis of miR-221 and p27 expression in human gliomas. Mol Med Report, 2, 651-6.
  14. Perz JF, Armstrong GL, Farrington LA, et al (2006). The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide. J Hepatol, 45, 529-38. https://doi.org/10.1016/j.jhep.2006.05.013
  15. Okubo M, Tahara T, Shibata T, et al (2010). Association between common genetic variants in pre-microRNAs and gastric cancer risk in Japanese population. Helicobacter, 15, 524-31. https://doi.org/10.1111/j.1523-5378.2010.00806.x
  16. Osada H, Takahashi T (2007). MicroRNAs in biological processes and carcinogenesis. Carcinogenesis, 28, 2-12. https://doi.org/10.1093/carcin/bgl185
  17. Ouyang YB, Stary CM, Yang GY, et al (2013). microRNAs:Innovative Targets for Cerebral Ischemia and Stroke. Curr Drug Targets, 14, 90-101. https://doi.org/10.2174/138945013804806424
  18. Qiu MT, Hu JW, Ding XX, et al (2012). Hsa-miR-499 rs3746444 polymorphism contributes to cancer risk: a meta-analysis of 12 studies. PLoS One, 7, e50887. https://doi.org/10.1371/journal.pone.0050887
  19. Ryan BM, Robles AI, Haris CC (2010). Genetic variation in microRNA networks: the implications for cancer research. Nat Rev Cancer, 10, 389-402. https://doi.org/10.1038/nrc2867
  20. Srivastava K, Srivastava A, Mittal B (2010). Common genetic variants in pre-microRNAs and risk of gallbladder can-cer in North Indian population. J Hum Genet, 55, 495-99. https://doi.org/10.1038/jhg.2010.54
  21. Srivastava K, Srivastava A (2012). Comprehensive review of genetic association studies and meta-analyses on miRNA polymorphisms and cancer risk. PLoS One, 7, e50966. https://doi.org/10.1371/journal.pone.0050966
  22. Stefani G, Slack FJ (2008). Small non-coding RNAs in animal development. Nat Rev Mol Cell Biol, 9, 219-30. https://doi.org/10.1038/nrm2347
  23. Xiang Y, Fan S, Cao J, et al (2012). Association of the microRNA-499 variants with susceptibility to hepatocellular carcinoma in a Chinese population. Mol Biol Rep, 39, 7019-23. https://doi.org/10.1007/s11033-012-1532-0
  24. Xu T, Zhu Y, Wei QK, et al (2008) A functional polymorphism in the miR-146a gene is associated with the risk for hepatocellular carcinoma. Carcinogenesis, 29, 2126-31. https://doi.org/10.1093/carcin/bgn195
  25. Zhou B, Wang K, Wang Y, et al (2011). Common genetic polymorphisms in pre-microRNAs and risk of cervical squamous cell carcinoma. Mol Carcinog, 50, 499-505. https://doi.org/10.1002/mc.20740
  26. Zhou J, Lv R, Song X, et al (2012). Association between two genetic variants in miRNA and primary liver cancer risk in the Chinese population. DNA Cell Biol, 31, 524-30. https://doi.org/10.1089/dna.2011.1340
  27. Zhou M, Liu Z, Zhao Y, et al (2010). MicroRNA-125b confers the resistance of breast cancer cells to paclitaxel through suppression of pro-apoptotic Bcl-2 antagonist killer 1 (Bak1) expression. J Biol Chem, 285, 21496-507. https://doi.org/10.1074/jbc.M109.083337

Cited by

  1. Associations of miR-499 and miR-34b/c Polymorphisms with Susceptibility to Hepatocellular Carcinoma: An Evidence-Based Evaluation vol.2013, pp.1687-630X, 2013, https://doi.org/10.1155/2013/719202
  2. Meta-analysis of Hsa-mir-499 polymorphism (rs3746444) for cancer risk: evidence from 31 case-control studies vol.15, pp.1, 2014, https://doi.org/10.1186/s12881-014-0126-1
  3. Association between a Variant in MicroRNA-646 and the Susceptibility to Hepatocellular Carcinoma in a Large-Scale Population vol.2014, pp.1537-744X, 2014, https://doi.org/10.1155/2014/312704
  4. Lack of Association between Hsa-Mir-499 rs3746444 Polymorphism and Cancer Risk: Meta-analysis Findings vol.16, pp.1, 2015, https://doi.org/10.7314/APJCP.2015.16.1.339
  5. Validation of microRNA pathway polymorphisms in esophageal adenocarcinoma survival vol.6, pp.2, 2017, https://doi.org/10.1002/cam4.989
  6. MicroRNA Gene Polymorphisms in Evaluating Therapeutic Efficacy After Transcatheter Arterial Chemoembolization for Primary Hepatocellular Carcinoma vol.20, pp.10, 2016, https://doi.org/10.1089/gtmb.2016.0073
  7. Comprehensive assessment for miRNA polymorphisms in hepatocellular cancer risk: a systematic review and meta-analysis vol.38, pp.5, 2018, https://doi.org/10.1042/BSR20180712
  8. A Meta-Analysis of miR-499 rs3746444 Polymorphism for Cancer Risk of Different Systems: Evidence From 65 Case-Control Studies vol.9, pp.1664-042X, 2018, https://doi.org/10.3389/fphys.2018.00737
  9. MicroRNA-Related Polymorphisms in Infectious Diseases—Tiny Changes With a Huge Impact on Viral Infections and Potential Clinical Applications vol.9, pp.1664-3224, 2018, https://doi.org/10.3389/fimmu.2018.01316
  10. Association of MicroRNA Polymorphisms With Hepatocellular Carcinoma in an Iranian Population vol.39, pp.1, 2019, https://doi.org/10.3343/alm.2019.39.1.58