DOI QR코드

DOI QR Code

Dilemmas of Oral Cancer Screening: An Update

  • Kujan, Omar (Department of Oral Medicine and Diagnostic Sciences, School of Dentistry, Al-Farabi College) ;
  • Sloan, Philip (School of Dental Sciences, University of Newcastle)
  • Published : 2013.05.30

Abstract

Oral cancer is a global health burden with high mortality and morbidity. Advances in treatment have failed to improve the relatively poor survival rate due to late-stage diagnosis. Early detection and screening have been shown to be effective in reducing mortality and morbidity of most common cancers. Several studies have evaluated the effectiveness of oral cancer screening programs but clear results were not obtained. This narrative commentary aimed to give a critical insight into the dilemma of oral cancer screening and to suggest recommendations for future trends. Conventional oral examination still constitutes the gold standard screening tool for potentially malignant oral lesions and cancer. Interestingly, the findings of the most lasting (15-year) randomized controlled trial on oral cancer screening using visual examination (Kerala) supported the introduction of a screening program in high-risk individuals. Several screening adjuncts exist but are still not at the introduction stage. Further research to find an appropriate adjunct reliable tool for oral cancer screening is needed. In conclusion, oral cancer fulfills most of the essential principles of cancer screening but still many points need to be clarified. Therefore, there is a striking need to establish a global consortium on oral cancer screening that will oversee research and provide recommendations for health authorities at regular intervals.

Keywords

References

  1. Awan KH, Morgan PR, Warnakulasuriya S (2011). Evaluation of an autofluorescence based imaging system $(VELscope^{TM})$ in the detection of oral potentially malignant disorders and benign keratoses. Oral Oncol, 47, 274-7. https://doi.org/10.1016/j.oraloncology.2011.02.001
  2. Begg C, Cho M, Eastwood S, et al (1996). Improving the quality of reporting of randomized controlled trials. The CONSORT statement. JAMA, 276, 637-9. https://doi.org/10.1001/jama.1996.03540080059030
  3. British Dental Association (2000). Opportunistic oral cancer screening: a management for dental practice. BDA Occasional. Paper 6: 1-36, 2000.Available from:www.bda.org/Images/mouth_cancer.pdf.
  4. Brocklehurst P, Kujan O, Glenny AM, et al (2010). Screening programmes for the early detection and prevention of oral cancer. Cochrane Database Syst Rev 11, CD004150.
  5. Epstein JB, Gorsky M, Cabay RJ, Day T, Gonsalves W (2008). Screening for and diagnosis of oral premalignant lesions and oropharyngeal squamous cell carcinoma. Can Fam Physician, 54, 870-5.
  6. Fedele S (2009). Diagnostic aids in the screening of oral cancer. Head Neck Oncol, 1, 5. https://doi.org/10.1186/1758-3284-1-5
  7. Ferlay J, Shin HR, Bray F, et al (2010). GLOBOCAN 2008 v2.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 10. Lyon, France: International Agency for Research on Cancer. Available from: http://globocan.iarc.fr.
  8. Johnson NW, Warnakulasuriya S, Gupta PC, et al (2011). Global oral health inequalities in incidence and outcomes for oral cancer: causes and solutions. Adv Dent Res, 23, 237-46. https://doi.org/10.1177/0022034511402082
  9. Kammerer PW, Koch FP, Santoro M, et al (2013). Prospective, blinded comparison of cytology and DNA-image cytometry of brush biopsies for early detection of oral malignancy. Oral Oncol, 12, 1368-8375.
  10. Kerr AR, Sirois DA, Epstein JB (2006).Clinical evaluation of chemiluminescent lighting: an adjunct for oral mucosal examinations. J Clin Dent, 17, 59-63.
  11. KujanOa, Duxbury AJ, Glenny AM, Thakker NS, Sloan P (2006). Opinions and attitudes of the UK's GDPs and specialists in oral surgery, oral medicine and surgical dentistry on oral cancer screening. Oral Dis, 12, 194-9. https://doi.org/10.1111/j.1601-0825.2005.01188.x
  12. Kujan Ob, Glenny AM, Oliver RJ, Thakker N, Sloan P (2006). Screening programmes for the early detection and prevention of oral cancer. Cochrane Database Syst Rev, 3, 4150.
  13. Kujan O, Glenny AM, Sloan P (2005). Screening for oral cancer. Lancet, 366, 1265-6. https://doi.org/10.1016/S0140-6736(05)67524-1
  14. Lavelle CL, Scully C (2005). Criteria to rationalize population screening to control oral cancer. Oral Oncol, 41, 11-6. https://doi.org/10.1016/j.oraloncology.2004.04.009
  15. Lingen MW, Kalmar JR, Karrison T, Speight PM (2008). Critical evaluation of diagnostic aids for the detection of oral cancer. Oral Oncol, 44, 10-22. https://doi.org/10.1016/j.oraloncology.2007.06.011
  16. Lingen MW (2011). Assuring dental student head and neck cancer screening competency. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 111, 267-8. https://doi.org/10.1016/j.tripleo.2010.11.024
  17. Lingen MW (2010). Screening for oral premalignancy and cancer: what platform and which biomarkers? Cancer Prev Res (Phila), 3, 1056-9. https://doi.org/10.1158/1940-6207.CAPR-10-0173
  18. Macek MD (2011). Using toluidine blue as an adjunct to oral visual cancer screening among high-risk individuals may lead to increased detection of oral submucous fibrosis. J Evid Based Dent Pract, 11, 200-2. https://doi.org/10.1016/j.jebdp.2011.09.003
  19. McGee S, Mirkovic J, Mardirossian V, et al (2008). Model-based spectroscopic analysis of the oral cavity: impact of anatomy. J Biomed Opt, 13, 64034. https://doi.org/10.1117/1.2992139
  20. McIntosh L, McCullough MJ, Farah CS (2009). The assessment of diffused light illumination and acetic acid rinse (Microlux/DL) in the visualisation of oral mucosal lesions. Oral Oncol, 45, 227-31. https://doi.org/10.1016/j.oraloncology.2009.08.001
  21. McNamara KK, Martin BD, Evans EW, Kalmar JR (2012). The role of direct visual fluorescent examination (VELscope) in routine screening for potentially malignant oral mucosal lesions. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 114, 636-43. https://doi.org/10.1016/j.oooo.2012.07.484
  22. Ovchinnikov DA, Cooper MA, Pandit P, et al (2012). Tumorsuppressor Gene Promoter Hypermethylation in Saliva of Head and Neck Cancer Patients. Transl Oncol, 5, 321-6. https://doi.org/10.1593/tlo.12232
  23. Pierce MC, Schwarz RA, Bhattar VS, et al (2012). Accuracy of in vivo multimodal optical imaging for detection of oral neoplasia. Cancer Prev Res (Phila), 5, 801-9. https://doi.org/10.1158/1940-6207.CAPR-11-0555
  24. Ramadas K, Arrossi S, Thara S, Sankaranarayanan R (2006). Keynote comment: importance of recognising scientific evidence. Lancet Oncol, 7, 962-3. https://doi.org/10.1016/S1470-2045(06)70950-0
  25. Ramadas K, Sankaranarayanan R, Jacob BJ, et al (2003). Interim results from a cluster randomized controlled oral cancer screening trial in Kerala, India. Oral Oncol, 39, 580-8. https://doi.org/10.1016/S1368-8375(03)00041-1
  26. Rethman MP, Carpenter W, Cohen EE, et al (2010). American dental association council on scientific affairs expert panel on screening for oral squamous cell carcinomas. evidencebased clinical recommendations regarding screening for oral squamous cell carcinomas. J Am Dent Assoc, 141, 509-20. https://doi.org/10.14219/jada.archive.2010.0223
  27. Sankaranarayanan R, Mathew B, Jacob BJ, et al (2000). Early findings from a community-based, cluster-randomized, controlled oral cancer screening trial in Kerala, India. The Trivandrum Oral Cancer Screening Study Group. Cancer, 88, 664-73. https://doi.org/10.1002/(SICI)1097-0142(20000201)88:3<664::AID-CNCR25>3.0.CO;2-V
  28. Sankaranarayanan R, Ramadas K, Thara S, et al (2013). Long term effect of visual screening on oral cancer incidence and mortality in a randomized trial in Kerala, India. Oral Oncol, 49, 314-21. https://doi.org/10.1016/j.oraloncology.2012.11.004
  29. Sankaranarayanan R, Ramadas K, Thomas G, et al (2005). Effect of screening on oral cancer mortality in Kerala, India: a cluster-randomised controlled trial. Lancet, 365, 1927-33. https://doi.org/10.1016/S0140-6736(05)66658-5
  30. Sankaranarayanan R, Sauvaget C, Ramadas Km, et al (2011). Clinical trials of cancer screening in the developing world and their impact on cancer healthcare. Ann Oncol, 22, 20-28.
  31. Schwarz RA, Gao W, Stepanek VM, et al (2010). Prospective evaluation of a portable depth-sensitive optical spectroscopy device to identify oral neoplasia. Biomed Opt Express, 2, 89-99.
  32. Seoane-Leston J, Diz Dios P (2010). Diagnostic clinical aids in oral cancer. Oral Oncol, 46, 418-22. https://doi.org/10.1016/j.oraloncology.2010.03.006
  33. Seoane-Romero JM, Vazquez-Mahia I, Seoane J, Varela-Centelles P, Tomas I, Lopez-Cedrun JL (2012). Factors related to late stage diagnosis of oral squamous cell carcinoma. Med Oral Patol Oral Cir Bucal, 17, 35-40.
  34. Smith RA, Cokkinides V, Brooks D, Saslow D, Shah M, Brawley OW (2011). Cancer screening in the United States, 2011: A review of current American Cancer Society guidelines and issues in cancer screening. CA Cancer J Clin, 61, 8-30. https://doi.org/10.3322/caac.20096
  35. Speight PM, Warnakulasuriya S (2010). Evaluation of screening for oral cancer against National Screening Committee Criteria. UK National Screening Committee Publications. Pages 1-13, 2010. Available from: http://www.screening.nhs.uk/oralcancer.
  36. Su WW, Yen AM, Chiu SY, Chen TH (2010). A communitybased RCT for oral cancer screening with toluidine blue. J Dent Res, 89, 933-7. https://doi.org/10.1177/0022034510373763
  37. Subramanian S, Sankaranarayanan R, Bapat B, et al (2009). Cost-effectiveness of oral cancer screening: results from a cluster randomized controlled trial in India. Bull World Hlth Organ, 87, 200-6. https://doi.org/10.2471/BLT.08.053231
  38. Tang H, Wu Z, Zhang J, Su B (2013). Salivary lncRNA as a potential marker for oral squamous cell carcinoma diagnosis. Mol Med Report, 7, 761-6.
  39. Tyagi A, Miller K, Cockburn M (2012). e-Health tools for targeting and improving melanoma screening: a review. J Skin Cancer, 2012, 8.
  40. Warnakulasuriya S (2009). Global epidemiology of oral and oropharyngeal cancer. Oral Oncol, 45, 309-16. https://doi.org/10.1016/j.oraloncology.2008.06.002

Cited by

  1. Fingerprint of Carcinogenic Semi-Volatile Organic Compounds (SVOCs) during Bonfire Night vol.14, pp.5, 2013, https://doi.org/10.7314/APJCP.2013.14.5.3243
  2. Collected at Nine Administrative Provinces in Northern Thailand during the Haze Episode in 2013 vol.14, pp.6, 2013, https://doi.org/10.7314/APJCP.2013.14.6.3653
  3. Effectiveness of the Microlux/DLTM Chemiluminescence Device in Screening of Potentially Malignant and Malignant Oral Lesions vol.15, pp.15, 2014, https://doi.org/10.7314/APJCP.2014.15.15.6081
  4. Oral Cancer Early Detection - a Pressing Need for Continuing Education in Jordan vol.16, pp.17, 2015, https://doi.org/10.7314/APJCP.2015.16.17.7727
  5. Inhibition of 4NQO-Induced Oral Carcinogenesis by Dietary Oyster Shell Calcium vol.15, pp.1, 2016, https://doi.org/10.1177/1534735415596572
  6. vol.16, pp.18, 2016, https://doi.org/10.7314/APJCP.2015.16.18.8605
  7. Oral Cancer Knowledge, Attitudes, and Practices among Dentists in Khartoum State, Sudan pp.1543-0154, 2017, https://doi.org/10.1007/s13187-017-1300-x