Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
권호 표지
DOI QR코드

DOI QR Code

Bisphosphonates for Osteoporosis in Nonmetastatic Prostate Cancer Patients Receiving Androgen-deprivation Therapy: A Systematic Review and Meta-analysis

  • Ding, Hui (Institute of Urology, Key Laboratory of Diseases of Urological System, Gansu Province, Gansu Nephro-Urological Clinical Center) ;
  • Yang, Li (Institute of Urology, Key Laboratory of Diseases of Urological System, Gansu Province, Gansu Nephro-Urological Clinical Center) ;
  • Du, Wan (Otolaryngological Department, The Second Hospital of Lanzhou University) ;
  • Teng, Yang (The People's Hospital of Rizhao Donggang Qu) ;
  • Fu, Sheng-Jun (Institute of Urology, Key Laboratory of Diseases of Urological System, Gansu Province, Gansu Nephro-Urological Clinical Center) ;
  • Tao, Yan (Institute of Urology, Key Laboratory of Diseases of Urological System, Gansu Province, Gansu Nephro-Urological Clinical Center) ;
  • Lu, Jian-Zhong (Institute of Urology, Key Laboratory of Diseases of Urological System, Gansu Province, Gansu Nephro-Urological Clinical Center) ;
  • Wang, Zhi-Ping (Institute of Urology, Key Laboratory of Diseases of Urological System, Gansu Province, Gansu Nephro-Urological Clinical Center)
  • Published : 2013.05.30
Download PDF
⟨ Previous Next ⟩

Abstract

This systematic review was conducted to assess the efficacy and safety of bisphosphonates for prevention and treatment of osteopenia or osteoporosis in men with non-metastatic prostate cancer receiving androgendeprivation therapy. We searched for randomised controlled trials (RCTs) of bisphosphonates compared with placebo from Pubmed, Embase, the Cochrane Library, and ISI - Science Citation Index. Meta-analyses of prespecified outcomes (bone mineral density, fractures, and adverse events) were performed using Review Manager. Ten RCTs with a total patient population of 1,017 were identified. There was generally more improvement in bone mineral density of the lumbar spine for patients who received bisphosphonate treatment than placebo or other medical treatment at 12 months (WMD 6.02,95%CI 5.39 to 6.65). Similar effects were also observed for total hip, trochanter or femoral neck bone mineral density. However, there was no significant reduction in fractures. Fever and gastrointestinal symptoms were the most common adverse events (10.4% vs. 1.2%; 0.10% vs. 0.03%). Currently, our meta-analysis suggested that oral and intravenous bisphosphonates caused a rapid increase in spine and hip or femoral BMD in non-metastatic prostate cancer patients receiving androgen-deprivation therapy. Fever and gastrointestinal symptoms were common with the use of bisphosphonates. These short-term trials (maximum of 12 months) did not show fracture reduction. In future, more efficient performance of higher quality, more rigorous, large sample, long-term randomised controlled trials (>12 months) are needed where outcomes are detailed.

Keywords

References

  1. Adler RA (2011). Management of osteoporosis in men onandrogen deprivation therapy. Maturitas, 68, 143-7. https://doi.org/10.1016/j.maturitas.2010.11.003
  2. Balasch J (2003). Sex steroids and bone: current perspectives. Hum Reprod Update, 9, 207-22. https://doi.org/10.1093/humupd/dmg017
  3. Bhoopalam N, Campbell SC, Moritz T, et al (2009). Intravenous zoledronic acid to prevent osteoporosis in a veteran population with multiple risk factors for bone loss on androgen deprivation therapy. J Urol, 182, 2257-64. https://doi.org/10.1016/j.juro.2009.07.046
  4. Bolla M (1999). Adjuvant hormonal treatment with radiotherapy for locally advanced prostate cancer. Eur Urol, 35, 23-5. https://doi.org/10.1159/000052303
  5. Brufsky AM (2008). Cancer treatment-induced bone loss: pathophysiology and clinical perspectives. Oncologist, 13, 187-95. https://doi.org/10.1634/theoncologist.2007-0152
  6. Casey R, Gesztesi Z, Rochford J (2010). Long term zoledronic acid during androgen blockade for prostate cancer. Can J Urol, 17, 5170-7.
  7. Eriksson S, Eriksson A, Stege R, et al (1995). Bone mineral density in patients with prostatic cancer treated with orchidectomy and with estrogens. Calcif Tissue Int, 57, 97-9. https://doi.org/10.1007/BF00298427
  8. Frydenberg M, Stricker PD, Kaye KW (1997). Prostate cancer diagnosis and management. Lancet, 349, 1681-7. https://doi.org/10.1016/S0140-6736(96)07393-X
  9. Greenspan SL, Nelson JB, Trump DL, et al (2007). Effect of once-weekly oral alendronate on bone loss in men receiving androgen deprivation therapy for prostate cancer: a randomized trial. Ann Intern Med, 146, 416-24. https://doi.org/10.7326/0003-4819-146-6-200703200-00006
  10. Grivas N, Hastazeris K, Kafarakis V, et al (2012). Prostate cancer epidemiology in a rural area of North Western Greece. Asian Pac J Cancer Prev, 13, 999-1002. https://doi.org/10.7314/APJCP.2012.13.3.999
  11. Higano CS (2004). Understanding treatments for bone loss and bone metastases in patients with prostate cancer: a practical review and guide for the clinician. Urol Clin North Am, 31, 331-52. https://doi.org/10.1016/j.ucl.2004.01.001
  12. Higano CS (2008). Androgen-deprivation-therapy-induced fractures in men with nonmetastatic prostate cancer: what do we really know? Nat Clin Pract Urol, 5, 24-34.
  13. Israeli RS, Rosenberg SJ, Saltzstein DR, et al (2007). The effect of zoledronic acid on bone mineral density in patients undergoing androgen deprivation therapy. Clin Genitourin Cancer, 5, 271-7. https://doi.org/10.3816/CGC.2007.n.003
  14. Jemal A, Siegel R, Ward E, et al (2009). Cancer statistics, 2009. CA Cancer J Clin, 59, 225-49. https://doi.org/10.3322/caac.20006
  15. Magno C, Anastasi G, Morabito N, et al (2005). Preventing bone loss during androgen deprivation therapy for prostate cancer: early experience with neridronate. Eur Urol, 47, 575-80. https://doi.org/10.1016/j.eururo.2005.01.012
  16. Maillefert JF, Sibilia J, Michel F, et al (1999). Bone mineral density in men treated with synthetic gonadotropin-releasing hormone agonists for prostatic carcinoma. J Urol, 161, 1219-22. https://doi.org/10.1016/S0022-5347(01)61639-2
  17. Manolagas SC, Kousteni S, Jilka RL (2002). Sex steroids and bone. Recent Prog Horm Res, 57, 385-409. https://doi.org/10.1210/rp.57.1.385
  18. Messing EM, Manola J, Sarosdy M, et al (1999). Immediate hormonal therapy compared with observation after radical prostatectomy and pelvic lymphadenectomy in men with node-positive prostate cancer. N Engl J Med, 341, 1781-8. https://doi.org/10.1056/NEJM199912093412401
  19. Michaelson MD, Kaufman DS, Lee H, et al (2007). Randomized controlled trial of annual zoledronic acid to prevent gonadotropin-releasing hormone agonist-induced bone loss in men with prostate cancer. J Clin Oncol, 25, 1038-42. https://doi.org/10.1200/JCO.2006.07.3361
  20. Michaud LB (2010). Managing cancer treatment-induced bone loss and osteoporosis in patients with breast or prostate cancer. Am J Health Syst Pharm, 67, S20-30. https://doi.org/10.2146/ajhp100078
  21. Morabito N, Gaudio A, Lasco A, et al (2004). Neridronate prevents bone loss in patients receiving androgen deprivation therapy for prostate cancer. J Bone Miner Res, 19, 1766-70. https://doi.org/10.1359/JBMR.040813
  22. Riggs BL, Khosla S, Melton LJ, 3rd (2002). Sex steroids and the construction and conservation of the adult skeleton. Endocr Rev, 23, 279-302. https://doi.org/10.1210/er.23.3.279
  23. Ryan CW, Huo D, Demers LM, et al (2006). Zoledronic acid initiated during the first year of androgen deprivation therapy increases bone mineral density in patients with prostate cancer. J Urol, 176, 972-8. https://doi.org/10.1016/j.juro.2006.04.078
  24. Ryan CW, Huo D, Bylow K, et al (2007). Suppression of bone density loss and bone turnover in patients with hormonesensitive prostate cancer and receiving zoledronic acid. BJU Int, 100, 70-5. https://doi.org/10.1111/j.1464-410X.2007.06853.x
  25. Serpa NA, Tobias-Machado M, Esteves MA, et al (2010). A systematic review and meta-analysis of bone metabolism in prostate adenocarcinoma. BMC Urol, 10, 9. https://doi.org/10.1186/1471-2490-10-9
  26. Sharifi N, Gulley J L, Dahut W L (2005). Androgen deprivation therapy for prostate cancer. Jama, 294, 238-44. https://doi.org/10.1001/jama.294.2.238
  27. Smith MR, McGovern FJ, Zietman AL, et al (2001). Pamidronate to prevent bone loss during androgen-deprivation therapy for prostate cancer. N Engl J Med, 345, 948-55. https://doi.org/10.1056/NEJMoa010845
  28. Smith MR, Eastham J, Gleason DM, et al (2003). Randomized controlled trial of zoledronic acid to prevent bone loss in men receiving androgen deprivation therapy for nonmetastatic prostate cancer. J Urol, 169, 2008-12. https://doi.org/10.1097/01.ju.0000063820.94994.95
  29. Smith MR, Saad F, Egerdie B, et al (2009). Effects of denosumab on bone mineral density in men receiving androgen deprivation therapy for prostate cancer. J Urol, 182, 2670-5. https://doi.org/10.1016/j.juro.2009.08.048
  30. Smith MR, Morton RA, Barnette KG, et al (2010). Toremifene to reduce fracture risk in men receiving androgen deprivation therapy for prostate cancer. J Urol, 184, 1316-21. https://doi.org/10.1016/j.juro.2010.06.022
  31. Taxel P, Dowsett R, Richter L, et al (2010). Risedronate prevents early bone loss and increased bone turnover in the first 6 months of luteinizing hormone-releasing hormone-agonist therapy for prostate cancer. BJU Int, 106, 1473-6. https://doi.org/10.1111/j.1464-410X.2010.09329.x

Cited by

  1. Analysis on Survival and Prognostic Factors for Cancer Patients with Malignancy-associated Hypercalcemia vol.14, pp.11, 2013, https://doi.org/10.7314/APJCP.2013.14.11.6715
  2. Prevalence of and Factors Associated with Osteoporosis among Korean Cancer Survivors: A Cross-Sectional Analysis of the Fourth and Fifth Korea National Health and Nutrition Examination Surveys vol.14, pp.8, 2013, https://doi.org/10.7314/APJCP.2013.14.8.4743
  3. Abiraterone for Treatment of Metastatic Castration-resistant Prostate Cancer: a Systematic Review and Meta-analysis vol.15, pp.3, 2014, https://doi.org/10.7314/APJCP.2014.15.3.1313
  4. Systematic review and network meta-analysis on the relative efficacy of osteoporotic medications: men with prostate cancer on continuous androgen-deprivation therapy to reduce risk of fragility fractures pp.14644096, 2017, https://doi.org/10.1111/bju.14015
  5. Zoledronic acid for the treatment of prostate cancer pp.1744-7666, 2019, https://doi.org/10.1080/14656566.2019.1574754
  6. Pain management using nanotechnology approaches vol.47, pp.1, 2019, https://doi.org/10.1080/21691401.2018.1553885