Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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For Which Cancer Types can Neuron-Specific Enolase be Clinically Helpful in Turkish Patients?

  • Published : 2013.04.30
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Abstract

Background: The aim of the present study was to evaluate the serum neuron-specific enolase (NSE) levels in patients with prostate cancer, Hodgkin lymphoma, lung cancer and peripheral nerve tumors. Materials and Methods: NSE levels were determined by ELISA in the sera of 100 prostate cancer, 47 Hodgkin lymphoma, 35 lung cancer and 35 peripheral nerve tumor patients and also in 132 healthy controls. Results: The median levels of serum NSE were elevated in patients with lung cancer (p=0.018) and peripheral nerve tumors (p=0.008). NSE levels in prostate cancer and Hodgkin lymphoma patients were higher than the controls but there was no statistically significant difference (p>0.05). Conclusions: We conclude that NSE may be applied in routine to gain insight about the clinical statuses of various cancer patients, but more studies are needed to determine the organ specificity.

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References

  1. Ather MH, Abbas F, Faruqui N, Israr M, Pervez S (2008). Correlation of three immunohistochemically detected markers of neuroendocrine differentiation with clinical predictors of disease progression in prostate cancer. BMC Urol, 8, 21. https://doi.org/10.1186/1471-2490-8-21
  2. Berruti A, Dogliotti L, Mosca A, et al (2000). Circulating neuroendocrine markers in patients with prostate carcinoma. Cancer, 88, 2590-7. https://doi.org/10.1002/1097-0142(20000601)88:11<2590::AID-CNCR23>3.0.CO;2-D
  3. Bossuyt PM, Reitsma JB, Bruns DE, et al (2004). Towards complete and Accurate reporting of studies of diagnostic accuracy: the STARD initiative. Fam Pract, 21, 4-10. https://doi.org/10.1093/fampra/cmh103
  4. Emin EA, Gunduz A, Batum O, et al (2010). Pre-treatment and treatment-induced neuron-specific enolase in patients with small-cell lung cancer: an open prospective study. Arch Bronconeumol, 46, 364-9.
  5. Fizazi K, Cojean I, Pignon JP, et al (1998). Normal serum neuron specific enolase (NSE) value after the first cycle of chemotherapy: an early predictor of complete response and survival in patients with small cell lung carcinoma. Cancer, 82, 1049-55. https://doi.org/10.1002/(SICI)1097-0142(19980315)82:6<1049::AID-CNCR6>3.0.CO;2-9
  6. Greenberg AK, Lee MS (2007). Biomarkers for lung cancer: clinical uses. Curr Opin Pulm Med, 13, 249-55. https://doi.org/10.1097/MCP.0b013e32819f8f06
  7. Humez S, Monet M, Legrand G, et al (2006). Epidermal growth factor-induced neuroendocrine differentiation and apoptotic resistance of androgen-independent human prostate cancer cells. Endocr Relat Cancer, 13, 181-95. https://doi.org/10.1677/erc.1.01079
  8. Hvamstad T, Jordal A, Hekmat N, Paus E, Fossa SD (2003). Neuroendocrine serum tumour markers in hormone-resistant prostate cancer. Eur Urol, 44, 215-21. https://doi.org/10.1016/S0302-2838(03)00257-4
  9. Kamiya N, Akakura K, Suzuki H, et al (2003). Pretreatment serum level of neuron specific enolase (NSE) as a prognostic factor in metastatic prostate cancer patients treated with endocrine therapy. Eur Urol, 44, 309-14. https://doi.org/10.1016/S0302-2838(03)00303-8
  10. Kodet R, Kodetova D, Smelhaus V (1991). Tumors of the peripheral sympathetic nervous system in childhood. Immunohistochemical study. Cesk Patol, 27, 97-104.
  11. Li X, Asmitananda T, Gao L, et al (2012). Biomarkers in the lung cancer diagnosis: a clinical perspective. Neoplasma, 59, 500-7. https://doi.org/10.4149/neo_2012_064
  12. Lilleby W, Paus E, Skovlund E, Fossa SD (2001). Prognostic value of neuroendocrine serum markers and PSA in irradiated patients with pN0 localized prostate cancer. Prostate, 46, 126-33. https://doi.org/10.1002/1097-0045(20010201)46:2<126::AID-PROS1016>3.0.CO;2-7
  13. Massarelli G, Onida GA, Piras MA, et al (1999). Neuron-specific enolase (gamma enolase, gamma-gamma dimer) expression in Hodgkin's disease and large cell lymphomas. Anticancer Res, 19, 3933-8.
  14. Nakatsuka S, Nishiu M, Tomita Y, et al (2002). Enhanced expression of neuron-specific enolase (NSE) in pyothoraxassociated lymphoma (PAL). Jpn J Cancer Res, 93, 411-6. https://doi.org/10.1111/j.1349-7006.2002.tb01272.x
  15. Pejcic I, Vrbic S, Filipovic S, et al (2010). Significance of serum tumor markers monitoring metastases in carcinomas of unknown primary site. Vojnosanit Pregl, 67, 723-31. https://doi.org/10.2298/VSP1009723P
  16. Peshavaria M, Day INM (1991). Molecular structure of the human muscle-specific enolase gene (EN03). Biochem J, 275, 427-33.
  17. Ramage JK, Davies AH, Ardill J, et al (2005). Guidelines for the management of gastroenteropancreatic neuroendocrine (including carcinoid) tumours. Gut, 4, 1-16.
  18. Schmidt D, Harms D, Burdach S (1985). Malignant peripheral neuroectodermal tumours of childhood and adolescence. Virchows Arch A Pathol Anat Histopathol, 406, 351-65. https://doi.org/10.1007/BF00704304
  19. Song TJ, Choi YC, Lee KY, Kim WJ (2012). Serum and cerebrospinal fluid neuron-specific enolase for diagnosis of tuberculous meningitis. Yonsei Med J, 53, 1068-72. https://doi.org/10.3349/ymj.2012.53.6.1068
  20. Sung HJ, Cho JY (2008). Biomarkers for the lung cancer diagnosis and their advances in proteomics. BMB Rep, 41, 615-25. https://doi.org/10.5483/BMBRep.2008.41.9.615
  21. Wojcik E, Jakubowicz J, Skotnicki P, Sas-Korczynska B, Kulpa JK (2010). IL-6 and VEGF in small cell lung cancer patients. Anticancer Res, 30, 1773-8.
  22. Xue F, Wang L, Zhang M, Cai L (2011). Clinical significance of detection of serum values of neuron specific enolase before and after treatment for small cell lung cancer. Zhongguo Fei Ai Za Zhi, 14, 723-6.
  23. Yasasever V, Meral R, Camlica H, Duranyildiz D, Dalay N (1999). Serum NSE levels in the Turkish population. J Tumor Marker Oncology, 14, 35-40.
  24. Zhao X, Wang M (2011). Clinical utility of serum tumor markers in lung cancer. Zhongguo Fei Ai Za Zhi, 14, 286-91.

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