Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
권호 표지
DOI QR코드

DOI QR Code

Current Evidence on Associations Between the MMP-7 (-181A>G) Polymorphism and Digestive System Cancer Risk

  • Ke, Pan (Department of General Surgery, Xiang-Ya 2nd Hospital, Central South University) ;
  • Wu, Zhong-De (Department of General Surgery, Xiang-Ya 2nd Hospital, Central South University) ;
  • Wen, Hua-Song (Department of General Surgery, Xiang-Ya 2nd Hospital, Central South University) ;
  • Ying, Miao-Xiong (Department of General Surgery, Xiang-Ya 2nd Hospital, Central South University) ;
  • Long, Huo-Cheng (Department of General Surgery, Xiang-Ya 2nd Hospital, Central South University) ;
  • Qing, Liu-Guo (Department of General Surgery, Xiang-Ya 2nd Hospital, Central South University)
  • Published : 2013.04.30
Download PDF
⟨ Previous Next ⟩

Abstract

Matrix metalloproteinases (MMPs) degrade various components of the extracellular matrix and functional polymorphisms in encoding genes may contribute to genetic susceptibility to many cancers. Up to now, associations between MMP-7 (-181A>G) and digestive system cancer risk have remained inconclusive. To better understand the role of the MMP-7 (-181A>G) genotype in digestive cancer development, we conducted this comprehensive meta-analysis encompassing 3,518 cases and 4,596 controls. Overall, the MMP-7 (-181A>G) polymorphism was associated with higher digestive system cancer risk on homozygote comparison (GG vs. AA, OR=1.21, 95% CI = 1.12-1.60) and in a dominant model (GG/GA vs. AA, OR=1.16, 95% CI =1.03-1.46). On subgroup analysis, this polymorphism was significantly linked to higher risks for gastric cancer (GG vs. AA, OR=1.22, 95% CI = 1.02-1.46; GA vs. AA, OR=1.82, 95% CI =1.16-2.87; GG/GA vs. AA, OR=1.13, 95% CI =1.01-1.27; GG vs. GA/AA, OR= 1.25, 95% CI = 1.06-2.39. We also observed increased susceptibility to colorectal cancer and esophageal SCC in both homozygote (OR = 1.13, 95% CI = 1.06-1.26) and heterozygote comparisons (OR = 1.45, 95% CI = 1.11-1.91). In the stratified analysis by controls, significant effects were only observed in population-based studies (GA vs. AA, OR=1.16, 95% CI=1.08-1.50; GA/AA vs. GG, OR=1.10, 95% CI=1.01-1.72). According to the source of ethnicity, a significantly increased risk was found among Asian populations in the homozygote model (GG vs. AA, OR=1.40, 95% CI=1.12-1.69), heterozygote model (GA vs. AA, OR=1.26, 95% CI=1.02-1.51), and dominant model (GG/GA vs. AA, OR=1.18, 95% CI=1.08-1.55). Our findings suggest that the MMP-7 (-181A>G) polymorphism may be a risk factor for digestive system cancer, especially among Asian populations.

Keywords

References

  1. Bo P, Lihuan C, Xiaopin M, et al (2010). Meta-analysis of association between matrix metalloproteinases 2, 7 and 9 promoter polymorphisms and cancer risk. Mutagenesis, 25, 371-9. https://doi.org/10.1093/mutage/geq015
  2. de Lima JM, de Souza LG, da Silva ID, et al (2009). E-cadherin and metalloproteinase-1 and-7 polymorphisms in colorectal cancer. Int J Biol Markers, 24, 99-106.
  3. Dziki L, Przybylowska K, Majsterek I, et al (2011). A/G Polymorphism of the MMP-7 Gene Promoter Region in Colorectal Cancer. Pol Przegl Chir, 83, 622-6.
  4. Fang W-L, Liang W-B, He H, et al (2010). Association of Matrix Metalloproteinases 1, 7, and 9 Gene Polymorphisms with Genetic Susceptibility to Colorectal Carcinoma in a Han Chinese Population. DNA Cell Biol, 29, 657-61. https://doi.org/10.1089/dna.2010.1017
  5. Ghilardi G, Biondi ML, Erario M, et al (2003). Colorectal carcinoma susceptibility and metastases are associated with matrix metalloproteinase-7 promoter polymorphisms. Clin Chem, 49, 1940-2. https://doi.org/10.1373/clinchem.2003.018911
  6. Greenwald RJ, Oosterwegel MA, van der Woude D, et al (2002). CTLA-4 regulates cell cycle progression during a primary immune response. Eur J Immunol, 32, 366-73. https://doi.org/10.1002/1521-4141(200202)32:2<366::AID-IMMU366>3.0.CO;2-5
  7. Hodi FS, Mihm MC, Soiffer RJ, et al (2003). Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients. Proc Natl Acad Sci USA, 100, 4712-17. https://doi.org/10.1073/pnas.0830997100
  8. Jormsjo S, Whatling C, Walter DH, et al (2001). Allele specific regulation of matrix metalloproteinase-7 promoter activity is associated with coronary artery luminal dimensions among hypercholesterolemic patients. Arterioscler Thromb Vasc Biol, 21, 1834-39. https://doi.org/10.1161/hq1101.098229
  9. Kim JH, Pyun JA, Lee KJ, et al (2011). [Study on association between single nucleotide polymorphisms of MMP7, MMP8, MMP9 genes and development of gastric cancer and lymph node metastasis]. Korean J Gastroenterol, 58, 245-51. https://doi.org/10.4166/kjg.2011.58.5.245
  10. Kubben FJGM, Sier CFM, Meijer MJW, et al (2006). Clinical impact of MMP and TIMP gene polymorphisms in gastric cancer. Br J Cancer, 95, 744-51. https://doi.org/10.1038/sj.bjc.6603307
  11. Li JY, Tian MM, Zhao AL (2008). Polymorphism in the promoter region of the metalloproteinase-7 increases susceptibility and risk of metastasis of gastric adenocarcinoma. Gastroenterology, 134, A603.
  12. Li Y, Jin X, Kang S, et al (2006). Polymorphisms in the promoter regions of the matrix metalloproteinases-1,-3,-7, and-9 and the risk of epithelial ovarian cancer in China. Gynecol Oncol, 101, 92-6. https://doi.org/10.1016/j.ygyno.2005.09.058
  13. Lievre A, Milet J, Carayol J, et al (2006). Genetic polymorphisms of MMP1, MMP3 and MMP7 gene promoter and risk of colorectal adenoma. BMC Cancer, 6, 270. https://doi.org/10.1186/1471-2407-6-270
  14. Malik MA, Sharma KL, Zargar SA, et al (2011). Association of matrix metalloproteinase-7 (-181A>G) polymorphism with risk of esophageal squamous cell carcinoma in Kashmir Valley. Saudi J Gastroenterol, 17, 301-6. https://doi.org/10.4103/1319-3767.84480
  15. Malik MA, Zargar SA, Mittal B (2011). Role of the metalloproteinase-7 (181A>G) polymorphism in gastric cancer susceptibility: a case control study in Kashmir valley. Asian Pac J Cancer Prev, 12, 73-6.
  16. Ohtani H, Maeda N, Murawaki Y (2009). Functional polymorphisms in the promoter regions of matrix metalloproteinase-2,-3,-7,-9 and TNF-alpha genes, and the risk of colorectal neoplasm in Japanese. Yonago Acta Medica, 52,47-56
  17. Qiu W, Zhou G, Zhai Y, et al (2008). No association of MMP-7, MMP-8, and MMP-21 polymorphisms with the risk of hepatocellular carcinoma in a Chinese population. Cancer Epidemiol Biomarkers Prev, 17, 2514-8. https://doi.org/10.1158/1055-9965.EPI-08-0557
  18. Singh H, Jain M, Mittal B (2008). MMP-7 (-181A>G) promoter polymorphisms and risk for cervical cancer. Gynecol Oncol, 110, 71-5. https://doi.org/10.1016/j.ygyno.2008.03.007
  19. Sugimoto M, Furuta T, Kodaira C, et al (2008). Polymorphisms of matrix metalloproteinase-7 and chymase are associated with susceptibility to and progression of gastric cancer in Japan. J Gastroenterol, 43,751-61. https://doi.org/10.1007/s00535-008-2221-6
  20. Vairaktaris E, Serefoglou Z, Yapijakis C, et al (2007). High gene expression of matrix metalloproteinase-7 is associated with early stages of oral cancer. Anticancer Res, 27, 2493-8.
  21. Woo M, Park K, Nam J, et al (2007). Clinical implications of matrix metalloproteinase-1,-3,-7,-9,-12, and plasminogen activator inhibitor-1 gene polymorphisms in colorectal cancer. J Gastroenterol Hepatol, 22, 1064-70. https://doi.org/10.1111/j.1440-1746.2006.04424.x
  22. Wu S, Lu S, Tao H, et al (2011). Correlation of polymorphism of IL-8 and MMP-7 with occurrence and lymph node metastasis of early stage cervical cancer. J Huazhong Univ Sci Technol, 31, 114-9. https://doi.org/10.1007/s11596-011-0161-5
  23. Zhang J (2005). The functional polymorphism in the matrix metalloproteinase-7 promoter increases susceptibility to esophageal squamous cell carcinoma, gastric cardiac adenocarcinoma and non-small cell lung carcinoma. Carcinogenesis, 26, 1748-53. https://doi.org/10.1093/carcin/bgi144

Cited by

  1. Overexpression of Twist and Matrix Metalloproteinase-9 with Metastasis and Prognosis in Gastric Cancer vol.14, pp.9, 2013, https://doi.org/10.7314/APJCP.2013.14.9.5055
  2. Hypomethylation of the MMP7 promoter and increased expression of MMP7 distinguishes the basal-like breast cancer subtype from other triple-negative tumors vol.146, pp.1, 2014, https://doi.org/10.1007/s10549-014-2989-4
  3. The MMP-2 -735 C Allele is a Risk Factor for Susceptibility to Breast Cancer vol.15, pp.15, 2014, https://doi.org/10.7314/APJCP.2014.15.15.6199
  4. Meta-analysis of Associations Between four Polymorphisms in the Matrix Metalloproteinases Gene and Gastric Cancer Risk vol.15, pp.3, 2014, https://doi.org/10.7314/APJCP.2014.15.3.1263
  5. Quantitative assessment of the associations between DNA repair gene XRCC3 Thr241Met polymorphism and gastric cancer vol.35, pp.2, 2014, https://doi.org/10.1007/s13277-013-1219-8
  6. Matrix Metalloproteinase-9 -1562T Allele and its Combination with MMP-2 -735 C Allele are Risk Factors for Breast Cancer vol.16, pp.3, 2015, https://doi.org/10.7314/APJCP.2015.16.3.1175