DOI QR코드

DOI QR Code

Survival Rate of Intrahepatic Cholangiocarcinoma Patients after Surgical Treatment in Thailand

  • Sriputtha, Sudarat (Department of Epidemiology, Faculty of Public Health, Khon Kaen University) ;
  • Khuntikeo, Narong (Department of Surgery, Faculty of Medicine, Khon Kaen University) ;
  • Promthet, Supannee (Department of Epidemiology, Faculty of Public Health, Khon Kaen University) ;
  • Kamsaard, Supot (Cancer Unit, Faculty of Medicine, Khon Kaen University)
  • 발행 : 2013.02.28

초록

Intrahepatic cholangiocarcinoma (ICC), one of the primary liver cancers, is frequent in the northeastern part of Thailand. Surgical resection remains the best method of treatment, but patients suffering from ICC usually present at a late stage of the disease. Studies of survival and prognostic factors after surgery remain rare. The aim here was to evaluate the survival rate and factors affecting the survival of patients with intrahepatic cholangiocarcinoma after surgery. The study used a retrospective cohort design. The subjects were 73 consecutive patients with ICC, who were admitted for surgery to Srinagarind Hospital, Khon Kaen University, during the period 2005-2009. The censoring date was 31 December, 2011, data being evaluated using uni- and multivariate analyses. Postoperative survival analysis was performed by the Kaplan-Meier method, and the Cox proportional hazard model was used to identify independent prognostic factors. The total follow-up time was 99 person-years. The total number of deaths was 59, giving a mortality rate of 59 per 100 person-years. The cumulative 1-, 3-, and 5-year survival rates were 52.1%, 21.7%, and 11.2%, respectively. The median duration of survival after resection was 12.4 months. Univariate analysis revealed stage of disease, lymph node metastasis, histological type, histological grade and macroscopic classification to be statistically significant (p-value<0.05) prognostic factors. In the multivariate analysis, only macroscopic classification was statistically significant (p-value<0.05). In conclusion, macroscopic classification was the only independent factor found to be significantly associated with survival following surgical treatment of ICC.

키워드

참고문헌

  1. American Cancer Society (2010). Cancer Facts and Figures 2010. Atlanta: American Cancer Society.
  2. Cho SY, Park SJ, Kim SH, et al (2010). Survival Analysis of Intrahepatic Cholangiocarcinoma after Resection. Ann Surg Oncol, 17, 1823-30. https://doi.org/10.1245/s10434-010-0938-y
  3. Curado MP, Edwards B, Shin HR, et al (2007). Cancer Incidence in Five Continents. Lyon, IARC Scientific Publications.
  4. Gores GJ (2003). Cholangiocarcinoma: current concepts and insights. Hepatology, 37, 961-9. https://doi.org/10.1053/jhep.2003.50200
  5. Guglielmi A, Ruzzenente A, Campagnaro T, et al (2009). Intrahepatic cholangiocarcinoma: prognostic factors after surgical resection. World J Surg, 33, 1247-54. https://doi.org/10.1007/s00268-009-9970-0
  6. Hanazaki K, Kajikawa S, Shimozawa N, et al (2002). Prognostic factors of intrahepatic cholangiocarcinoma after hepatic resection: univariate and multivariate analysis. Hepatogastroenterology, 44, 311-6.
  7. Hirohashi K, Uenishi T, Kubo S, et al (2002). Macroscopic types of intrahepatic cholangiocarcinoma:clinicopathologic features and surgical outcomes. Hepatogastroenterology, 49, 326-9.
  8. Khan SA, Thomas HC, Davison BR, Taylor-Robinson SD (2005). Cholangiocarcinoma. Lancet, 366, 1303-14. https://doi.org/10.1016/S0140-6736(05)67530-7
  9. Khuntikeo N, Phugkhem A, Bhudhisawasdi V, et al (2008). Major hepatic resection for hilar cholangiocarcinoma without preoperative biliary drainage. Asian Pac J Cancer Prev, 9, 83-5.
  10. Morimoto Y, Tanaka Y, Ito T, et al (2003). Long-term survival and prognostic factors in the surgical treatment for intrahepatic cholangiocarcinoma. J Hepatobiliary Pancreat Surg, 10. 432-40. https://doi.org/10.1007/s00534-002-0842-3
  11. Morise Z, Sugioka A, Tokoro T, et al (2010). Surgery and chemotherapy for intrahepatic Cholangiocarcinoma. World J Hepatol, 27, 58-64.
  12. Pattanathien P, Khuntikeo N, Promthet S, et al (2013). Survival rate of extrahepatic cholangiocarcinoma patients after surgical treatment in Thailand. Asian Pac J Cancer Prev, 14, 20-30.
  13. Ribero D, Pinna AD, Guglielmi A (2012). Surgical approach for long-term survival of patients with intrahepatic cholangiocarcinoma: a multi-institutional analysis of 434 patients. Arch Surg, 147, 1107-13 https://doi.org/10.1001/archsurg.2012.1962
  14. Saengsawang P, Promthet S, Bradshaw P (2012). Prevalence of OV infection in Yasothon Province, Northeast Thailand. Asia Pacific J Cancer Prev, 23, 3399-402.
  15. Shen WF, Zhong W, Xu F, et al (2009). Clinicopathological and prognostic analysis of 429 patients with intrahepatic cholangiocarcinoma. World J Gastroenterol, 15, 5976-82. https://doi.org/10.3748/wjg.15.5976
  16. Sriamporn S, Black R, Sankaranarayanan R, et al (1995). Cancer survival in Khon Kaen Province, Thailand. Int J Cancer, 61, 296-300. https://doi.org/10.1002/ijc.2910610303
  17. StataCorp LP (2007). Stata Release 10: User's guide. College Station TX: Stata Press.
  18. Suzuki S, Sakaguchi T, Yokoi Y, et al (2002). Clinicopathological prognostic factors and impact of surgical treatment of mass-forming intrahepatic cholangiocarcinoma. World J Surg, 26, 687-93. https://doi.org/10.1007/s00268-001-0291-1
  19. Uenishi T, Hirohashi K, Kubo S, et al (2001). Clinicopathological factors predicting outcome after resection of mass-forming intrahepatic cholangiocarcinoma. Br J Surg, 88, 969-74. https://doi.org/10.1046/j.0007-1323.2001.01784.x
  20. Vatanasapt V, Martin N, Sriplung H, et al (1995). Cancer incidence in Thailand, 1988-1991. Cancer Epidemiol Biomarkers Prev, 4, 475-83.
  21. Vatanasapt V, Tangvoraphonkchai V, Titapant V, et al (1990). A high incidence of liver cancer in Khon Kaen Province, Thailand. Southeast Asian J Trop Med Public Health, 21, 489-94.

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