Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Identification of Serum MicroRNA-21 as a Biomarker for Early Detection and Prognosis in Human Epithelial Ovarian Cancer

  • Xu, Yun-Zhao (Department of Obstetrics and Gynecology, Affiliated Hospital of Nan Tong University) ;
  • Xi, Qing-Hua (Department of Obstetrics and Gynecology, Affiliated Hospital of Nan Tong University) ;
  • Ge, Wen-Liang (Department of Pediatric Surgery, Affiliated Hospital of Nan Tong University) ;
  • Zhang, Xiao-Qian (Department of Obstetrics and Gynecology, Affiliated Hospital of Nan Tong University)
  • Published : 2013.02.28
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Abstract

Recent investigations have confirmed up-regulation of serum miR-21 and its diagnostic and prognostic value in several human malignancies. In this study, we examined serum miR-21 levels in epithelial ovarian cancer (EOC) patients, and explored its association with clinicopathological factors and prognosis. The results showed significantly higher serum miR-21 levels in EOC patients than in healthy controls. In addition, increased serum miR-21 expression was correlated with advanced FIGO stage, high tumor grade, and shortened overall survival. These findings indicate that serum miR-21 may serve as a novel diagnostic and prognostic marker, and be used as a therapeutic target for the treatment of EOC.

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References

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