Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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miR-19a Promotes Cell Growth and Tumorigenesis through Targeting SOCS1 in Gastric Cancer

  • Qin, Shuang (Department of General Surgery, First Affiliated Hospital of Xinxiang Medical University) ;
  • Ai, Fang (Department of Pediatric Surgery, First Affiliated Hospital of Xinxiang Medical University) ;
  • Ji, Wei-Fang (Department of Pediatric Surgery, First Affiliated Hospital of Xinxiang Medical University) ;
  • Rao, Wang (Department of Pediatric Surgery, First Affiliated Hospital of Xinxiang Medical University) ;
  • Zhang, He-Cheng (Department of Pediatric Surgery, First Affiliated Hospital of Xinxiang Medical University) ;
  • Yao, Wen-Jian (Department of Thoracic Surgery, First Affiliated Hospital of Xinxiang Medical University)
  • Published : 2013.02.28
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Abstract

Accumulating evidence has shown that microRNAs are involved in cancer development and progression. However, it remains unknown about the potential role of miR-19a in the pathogenesis of gastric cancer. Here, we report that suppressor of cytokine signaling 1 (SOCS1) is a novel target of miR-19a in gastric cancer cells and that miR-19a expression is inversely correlated with SOCS1 expression in gastric cancer cells and a subset of gastric cancer tissues. Ectopic expression of miR-19a dramatically promoted proliferation and tumorigenicity of gastric cancer cells both in vitro and in vivo. Moreover, we showed that silencing of SOCS1 promoted cell growth and colony formation resembling that of miR-19a overexpression, whereas re-introduction of SOCS1 (without the 3'-UTR) attenuated the pro-tumorigenic functions. Taken together, our findings suggest that the SOCS1 gene is a direct target of miR-19a, which functions as an oncogenic miRNA in gastric cancer by repressing the expression of tumor suppressor SOCS1.

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References

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