DOI QR코드

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Low Level of Consanguinity in Moroccan Families at High Risk of Breast Cancer

  • 발행 : 2013.02.28

초록

Background: Breast cancer is worldwide the most common cancer in women and is a major public health problem. Genes with high or low penetrance are now clearly implicated in the onset of breast cancer, mostly the BRCA genes. All women in families at high risk of breast cancer do not develop tumours, even when they carry the familial mutation, suggesting the existence of genetic and environmental protective factors. Several studies have shown that consanguinity is linked to a decreased or an increased risk of breast cancer, but to the best of our knowledge, there is no study concerning the association between consanguinity and the occurrence of tumours in women with high risk of breast cancer. The objective of this study was to examine whether parental consanguinity in families with genetic predisposition to breast cancer affect the risk of siblings for having this cancer. Materials and Methods: Over a six-year period, 72 different patients with a histological diagnosis of breast or ovarian cancer from 42 families were recruited for genetic counselling to the Department of Medical Genetics, Rabat. Consanguinity rate was determined in cases and compared to the consanguinity rate in the Moroccan general population. Results: Consanguinity rates were 9.72% in patients and 15.3% in controls, but the difference was statistically not significant (p>0.001) and the mean coefficient of consanguinity was lower in breast cancer patients (0.0034) than in controls (0.0065). Conclusions: Despite the relatively small sample size of the current study, our results suggest that parental consanguinity in Moroccan women might not be associated with an altered risk of breast cancer. Large scale studies should be carried out to confirm our results and to develop public health programs.

키워드

참고문헌

  1. Alshatwi AA, Hasan TN, Shafi G, et al (2011). A single-nucleotide polymorphism in the TP53 and MDM-2 gene modifies breast cancer risk in an ethnic Arab population. Fundam Clin Pharmacol, 26, 438-43.
  2. Antoniou AC, Easton DF (2003). Polygenic inheritance of breast cancer: implications for design of association studies. Genet Epidemiol, 25, 190-202. https://doi.org/10.1002/gepi.10261
  3. Antoniou A, Pharoah PD, Narod S, et al (2003). Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case series unselected for family history: a combined analysis of 22 studies. Am J Hum Genet, 72, 1117-30. https://doi.org/10.1086/375033
  4. Assie G, LaFramboise T, Platzer P, et al (2008). Frequency of germline genomic homozygosity associated with cancer cases. JAMA, 299, 1437-45. https://doi.org/10.1001/jama.299.12.1437
  5. Bener A, El Ayoubi HR, Ali AI, et al (2010). Does consanguinity lead to decreased incidence of breast cancer? Cancer Epidemiology, 34, 413-8. https://doi.org/10.1016/j.canep.2010.04.004
  6. Boyley P, Ferlay J (2005). Cancer incidence and mortality in Europe. Ann Oncol, 16, 481-8. https://doi.org/10.1093/annonc/mdi098
  7. Denic S, Bener A (2001). Consanguinity decreases risk of breast cancer-cervical cancer unaffected. Bri J Cancer, 85, 1675-9. https://doi.org/10.1054/bjoc.2001.2131
  8. Denic S, Al-Gazali L (2002). Breast cancer, consanguinity, and lethal tumor genes: simulation of BRCA1/2 prevalence over 40 generations. Int J Mol Med, 10, 713-9.
  9. Denic S, Al-Gazali L (2003). BRCA1 and BRCA2 mutations in breast cancer patients from Saudi Arabia. Saudi Med J, 24, 696.
  10. Denic S, Bener A, Sabri S, et al (2005). Parental consanguinity and risk of breast cancer: a population-based case-control study. Med Sci Monit, 11, 415-9.
  11. Denic S, Frampton C, Nicholls MG (2007). Risk of cancer in an inbred population. Cancer Detect Prev, 31, 263-9. https://doi.org/10.1016/j.cdp.2007.07.006
  12. Gilani G, Kamal S (2004). Risk factors for breast cancer in Pakistani women aged less than 45 years. Ann Hum Biol, 31, 398-407. https://doi.org/10.1080/0301446042000226763
  13. Grant JC, Bittles AH (1997). The comparative role of consanguinity in infant and childhood mortality in Pakistan. Ann Hum Genet, 61, 143-9. https://doi.org/10.1017/S0003480097006039
  14. Hakem R, De la pompa JL, Mak TW (1998). Developmental studies of BRCA1 and BRCA2 knock out mice. J Mammary Gland Biol Neoplasia, 3, 431-45. https://doi.org/10.1023/A:1018792200700
  15. Jaber L, Halpern GJ, Shohat M (1998). The impact of consanguinity worldwide. Commun Genet, 1, 12-7. https://doi.org/10.1159/000016130
  16. Jaouad IC, Elalaoui SC, Sbiti A, et al (2009). Consanguineous marriages in morocco and the consequence for the incidence of autosomal recessive disorders. J Biosoc Sci, 41, 575-81. https://doi.org/10.1017/S0021932009003393
  17. Khlat M (1997). Endogamy in the Arab world. In genetic disorders among Arab populations. AS. Teebi and TI. Farag, eds. New York, 1997:63-80.
  18. Laarabi FZ, Jaouad IC, Ouldim K, et al (2011). Genetic testing and first presymptomatic diagnosis in Moroccan families at high risk of breast/ovarian cancer. Oncol Lett, 2, 389-93.
  19. Latif A, Hadfield KD, Roberts SA, et al (2010). Breast cancer susceptibility variants alter risks in familial disease. J Med Genet, 47, 126-31. https://doi.org/10.1136/jmg.2009.067256
  20. Liede A, Malik IA, Aziz Z, et al (2002). Contribution of BRCA1and BRCA2 mutations to breast and ovarian cancer in Pakistan. Am J Hum Genet, 71, 595-606. https://doi.org/10.1086/342506
  21. Rowell S, Newman B, Boyd J, et al (1994). Inherited predisposition to breast and ovarian cancer. Am J Hum Genet, 55, 861-5.
  22. Rudan I (1999). Inbreeding and cancer incidence in human isolates. Hum Biol, 71, 173-87.
  23. Shami SA, Qaisar R, Bittles AH (1991). Consanguinity and adult morbidity in Pakistan. Lancet, 338, 954-5.
  24. Simpson JL, Martin AO, Elias S, et al (1981). Cancers of the breast and female genital system: search for recessive genetic factors through analysis of human isolate. Am J Obstet Gynecol, 141, 629-36.
  25. Zhang B, Beeghly-Fadiel A, Long J, et al (2011). Genetic variants associated with breast-cancer risk: comprehensive research synopsis, meta-analysis, and epidemiological evidence. Lancet Oncol, 12, 477-88. https://doi.org/10.1016/S1470-2045(11)70076-6

피인용 문헌

  1. Consanguinity Protecting Effect Against Breast Cancer among Tunisian Women: Analysis of BRCA1 Haplotypes vol.16, pp.9, 2015, https://doi.org/10.7314/APJCP.2015.16.9.4051
  2. Breast cancer protection by genomic imprinting in close kin families vol.18, pp.1, 2017, https://doi.org/10.1186/s12881-017-0498-0
  3. First application of next-generation sequencing in Moroccan breast/ovarian cancer families and report of a novel frameshift mutation of the BRCA1 gene vol.12, pp.2, 2016, https://doi.org/10.3892/ol.2016.4739
  4. A meta-analysis of consanguinity and breast cancer vol.187, pp.4, 2018, https://doi.org/10.1007/s11845-018-1791-4