Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
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Systematic review of the effect of coenzyme Q10 on antioxidant capacity while focused on evaluation of claims for health functional food

건강기능식품의 기능성을 중심으로 한 코엔자임Q10의 항산화 기능성에 대한 체계적 고찰

  • Kim, Ji Yeon (Department of Food Science and Technology, Seoul National University of Science and Technology) ;
  • Jeong, Sewon (Biofood Network Center, Ewha Womans University) ;
  • Paek, Ju Eun (Biofood Network Center, Ewha Womans University) ;
  • Kim, Joohee (Biofood Network Center, Ewha Womans University) ;
  • Kwak, Jin Sook (Biofood Network Center, Ewha Womans University) ;
  • Lee, Yoon Jung (Biofood Network Center, Ewha Womans University) ;
  • Kang, Tae Seok (Nutrition and Functional Food Research Team, Korea Food and Drug Administration) ;
  • Kwon, Oran (Biofood Network Center, Ewha Womans University)
  • 김지연 (서울과학기술대학교 식품공학과) ;
  • 정세원 (이화여자대학교 바이오푸드네트워크사업단) ;
  • 백주은 (이화여자대학교 바이오푸드네트워크사업단) ;
  • 김주희 (이화여자대학교 바이오푸드네트워크사업단) ;
  • 곽진숙 (이화여자대학교 바이오푸드네트워크사업단) ;
  • 이윤정 (이화여자대학교 바이오푸드네트워크사업단) ;
  • 강태석 (식품의약품안전평가원 영양기능연구팀) ;
  • 권오란 (이화여자대학교 바이오푸드네트워크사업단)
  • Received : 2013.02.05
  • Accepted : 2013.04.30
  • Published : 2013.06.30
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Abstract

Although the functional ingredient has been evaluated by the Korea Food and Drug Administration (KFDA) based on scientific evidence, the levels of scientific evidence and consistency of the results might vary according to emerging data. Therefore, periodic re-evaluation may be needed for some functional ingredients. In this study, we re-evaluated scientific evidence for the antioxidant activity of coenzyme Q10 as a functional ingredient in health functional food. Literature searches were conducted using the Medline and Cochrane, KISS, and IBIDS databases for the years 1955-2010 with the search term of coenzyme Q10 in combination with antioxidant. The search was limited to human studies published in Korean, English, and Japanese. Using the KFDA's evidence based evaluation system for scientific evaluation of health claims, 33 human studies were identified and reviewed in order to evaluate the strength of the evidence supporting a relation between coenzyme Q10 and antioxidant activity. Among 33 studies, significant effects for antioxidant activities were reported in 22 studies and their daily intake amount was 60 to 300 mg. Based on this systematic review, we concluded that there was possible evidence to support a relation between coenzyme Q10 intake and antioxidant activities. However, because inconsistent results have recently been reported, future studies should be monitored.

Keywords

References

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