Journal of Nutrition and Health

  • 제46권3호
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  • Pages.207-217
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  • 2013
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  • 2288-3886(pISSN)
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  • 2288-3959(eISSN)
한국영양학회 (The Korean Nutrition Society)
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인진쑥 추출물이 다이옥신계 TCDD (2,3,7,8-Tetrachlorodibenzo-p-dioxin)에 노출된 흰쥐의 간 기능 및 지질대사에 미치는 효과

Effects of Artemisia capillaris extract on disorders of hepatic functions and lipid metabolism in rats treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

  • 이준호 (충남대학교 생활과학대학 소비자생활정보학과) ;
  • 장춘뢰 (충남대학교 생활과학대학 소비자생활정보학과) ;
  • 필수초 (충남대학교 생활과학대학 소비자생활정보학과) ;
  • 황석연 (대전대학교 자연과학대학 임상병리학과)
  • Lee, Joon Ho (Department of Consumers' Life Information, Chungnam National University) ;
  • Zhang, Chun Lei (Department of Consumers' Life Information, Chungnam National University) ;
  • Bi, Shou Chao (Department of Consumers' Life Information, Chungnam National University) ;
  • Hwang, Seok Youn (Department of Biomedical Laboratory Science, Daejeon University)
  • 투고 : 2013.03.26
  • 심사 : 2013.05.21
  • 발행 : 2013.06.30
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초록

This study was conducted in order to investigate the effects of Artemisia capillaris (AC) extract on disorders of hepatic functions and lipid metabolism induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), an endocrine disrupter, using male rats (SD, five weeks old) for a period of three weeks. These 37 animals were divided into four groups. AC extract was added as 1.5% or 3% levels to basal diets, respectively. TCDD (40 ug/kg B.W) was administered by intraperitoneal injection into rats after a week from the beginning of the experiment. AC extract alleviated the increase of rat's relative liver weights induced by TCDD. Thymuses of all rats treated with TCDD were apparently shrunken by approximately 80%. Levels of white blood cells (WBC), red blood cells, hemoglobin, and hematocrits were significantly increased by treatment with TCDD, however, WBC tended to decrease by AC extract diets. In hepatic function, the elevation of glutamic oxalacetic transaminase activities by TCDD treatment was diminished by AC extract diets. Serum HDL-cholesterol levels were significantly elevated by AC extract diets. The apparent increase of triglyceride levels of rat livers induced by TCDD was significantly suppressed in the AC extract diet groups. Hepatic cytosolic catalase activities significantly decreased by treatment with TCDD showed a recovering trend by AC extract diets. In histochemical observation, the fat droplets and apoptosis of hepatocytes treated with TCDD were markedly alleviated by AC extract diets. These results indicated that AC could exert recovering effects on some disorders of hepatic functions, lipids metabolism, and antioxidant activities resulting from TCDD treatment.

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피인용 문헌

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  2. 고본양정방 투여가 TCDD 유도 랫드의 항산화 변화에 미치는 영향 vol.21, pp.10, 2013, https://doi.org/10.5762/kais.2020.21.10.231
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  4. 고본양정방 투여가 TCDD 유도 랫드의 생식독성에 미치는 영향 vol.22, pp.4, 2013, https://doi.org/10.5762/kais.2021.22.4.504