Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Ameliorative Effect of the Water Extract from Cirsium japonicum var. ussuriense Leaves on Blood Circulation in a Rat Model of Topical Ferric Chloride-Induced Carotid Artery Damage

Ferric Chloride로 유도된 렛트 경동맥 손상 및 혈전에 대한 수용성 엉겅퀴 잎 추출물의 혈행 개선 효과

  • Received : 2013.04.09
  • Accepted : 2013.05.07
  • Published : 2013.06.30
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Abstract

The present study has been undertaken to investigate the effect of the extract of Cirsium japonicum var. ussuriense leaves (CLE) on blood circulation in a rat model of topical ferric chloride ($FeCl_3$)-induced carotid artery damage. $FeCl_3$ treatment seriously damaged the carotid artery such as the walls of the artery, blood flow and inflammation. However, CLE administration has ameliorated blood circulation and suppressed vessel inflammation. CLE administration also has ameliorated the $FeCl_3$-induced artery tissue damage. Furthermore, CLE significantly suppressed the expression of adhesion molecules. These results suggest that CLE ameliorate blood circulation through suppress inflammatory mediator and adhesion molecule production.

Keywords

References

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