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A case of canine bilateral ovary granulosa cell tumor and mammary complex carcinoma

  • Chung, Yung-Ho (Department of Companion Animal and Animal Resources Science, Joongbu University) ;
  • Hong, Sunhwa (Center for Animal Resource Development, Wonkwang University) ;
  • Han, Sang-Jun (Center for Animal Resource Development, Wonkwang University) ;
  • Kim, Okjin (Center for Animal Resource Development, Wonkwang University)
  • Received : 2013.02.05
  • Accepted : 2013.05.08
  • Published : 2013.06.30

Abstract

An 11-year-old poodle bitch was presented for investigation of multicentric mammary masses. Abdominal sonography and radiography demonstrated abnormal enlargement of uterus and ovaries. Blood analysis revealed high progesterone concentration. The ovariohysterectomy and mastectomy were performed. Histopathologically, the mammary masses revealed complex carcinoma-tubulopapillary carcinoma with papillary pattern and tubule pattern. In the uterus, cystic endometrial hyperplasia was observed. Scattered inflammatory cells were observed in the endometrial stroma and mucinous material was protruded from endometrial surface. Also, in the ovaries, bilateral ovary granulosa cell tumor was detected. The bitch made a complete recovery following the ovariohysterectomy and mastectomy. This case was a very rare multiple tumor occurrence with bilateral ovary granulosa cell tumor and mammary complex carcinoma. High progesterone concentration was characterized clinically in the bitch.

Keywords

References

  1. Bodner K, Bodner-Adler B, Kimberger O, Czerwenka K, Mayerhofer K. 2004. Estrogen and progesterone receptor expression in patients with uterine smooth muscle tumours. Fertil Steril 81: 1062-1066. https://doi.org/10.1016/j.fertnstert.2003.08.043
  2. Chu P, Salamonsen LA, Lee CS. Wright PJ, 2002. Matrix metalloproteinases (MMPs) in the endometrium of bitches. Reproduction 123: 467-477. https://doi.org/10.1530/rep.0.1230467
  3. Cohen D, Reif JS, Brodey RS, Keiser H. 1974. Epidemiologic analysis of the most prevalent sites and types of canine neoplasia in a veterinary hospital. Cancer Res 34: 2859-2868.
  4. Davidson AP, Feldman EC. 2005. Ovarian and estrous cycle abnormalities. pp. 1649-1655. In: Ettinger SJ, Feldman EC(ed.). Textbook of veterinary internal medicine. Elsevier Saunders, St. Louis, USA.
  5. Feldman EC, Nelson RW. 1987. Canine female reproduction. pp. 399-480. In: Feldman EC, Nelson RW(Ed.). Canine and feline endocrinology and reproduction. WB Saunders, Philadelphia.
  6. Graves PE, Surwit EA, Davis JR, Stouffer RL. 1985. Adenylate cyclase in human ovarian cancers: sensitivity to gonadotrophins and nonhormonal activators. Am J Obstet Gynecol 153: 877-882. https://doi.org/10.1016/0002-9378(85)90693-3
  7. Kim O, Kim KS. 2005. Development of Mammary tumor and endometrial hyperplasia in a dog using chemical contraception. Lab Anim Res 21: 180-182.
  8. Klein MK. 2001. Tumors of the female reproductive system. pp. 445-454. In: Withrow SJ, MacEwen EG(ed.). Small animal clinical oncology. W.B. Saunders, Philadelphia.
  9. Leitner M, Aurich JE, Galabova G, Aurich C, Walter I. 2002. Lectin binding patterns in normal canine endometrium and in bitches with pyometra and cystic endometrial hyperplasia. Histol Histopathol 18: 787-795.
  10. Martin De Las Mulas J, Millan Y, Bautista MJ, Perez J, Carrasco L. 2000. Oestrogen and progesterone receptors in feline fibroadenomatous change: an immunohistochemical study. Res Vet Sci 68: 15-22. https://doi.org/10.1053/rvsc.1999.0327
  11. McCandlish IA, Munro CD, Breeze RG, Nash AS. 1979. Hormone producing ovarian tumours in the dog. Vet Rec 105: 9-11. https://doi.org/10.1136/vr.105.1.9
  12. McEntee K. 1990. Ovarian neoplasms. pp. 69-93. In: McEntee K(ed.). Reproductive pathology of domestic mammals. Academic Press, San Diego.
  13. McLachlan NJ. 1987. Ovarian disorders in domestic animals. Environ Health Perspect 73: 27-33. https://doi.org/10.1289/ehp.877327
  14. MacLachlan NJ, Kennedy PC. 2002. Tumors of the genital system. pp. 547-573. In: Meuten DJ(ed.). Tumors in domestic animals. Iowa State Press, Ames.
  15. Millan Y, Gordon A, De Los Monteros AE, Reymundo C, Martíndelas Mulas J. 2007. Steroid receptors in canine and human female genital tract tumours with smooth muscle differentiation. J Comp Pathol 136: 197-201. https://doi.org/10.1016/j.jcpa.2007.01.004
  16. Misdorp W. 2002. Tumors of the mammary gland. pp. 575-606. In: Meuten DJ(ed.). Tumors in domestic animals. Iowa State Press, Ames.
  17. Munson L, Gardner IA, Mason RJ, Chassy LM, Seal US. 2002. Endometrial hyperplasia and mineralization in zoo felids treated with melengestrol acetate contraceptives. Vet Pathol 39: 419-427. https://doi.org/10.1354/vp.39-4-419
  18. Pazol K, Wilson ME, Wallen K. 2004. Medroxyprogesterone acetate antagonizes the effects of estrogen treatment on social and sexual behavior in female Macaques. J Clin Endocrinol Metab 89: 2998-3006. https://doi.org/10.1210/jc.2003-032086
  19. Patnaik AK, Greenlee PG. 1987. Canine ovarian neoplasms: a clinicopathologic study of 71 cases including histology of 12 granulosa cell tumors. Vet Pathol 24: 509-514. https://doi.org/10.1177/030098588702400607
  20. Purswell BJ, Parker NA, Bailey TL, Dascanio JJ, Sponenberg DP. 1999. Theriogenology question of the month. Persistent estrus caused by functional granulosa cell tumor of the left ovary. J Am Vet Med Assoc 215: 193-195.
  21. Schafer KA, Kelly G, Schrader R, Griffith WC, Muggenburg BA, Tierney LA, Lechner JF, Janovitz EB, Hahn FF. 1998. A canine model of familial mammary gland neoplasia. Vet Pathol 35: 168-177. https://doi.org/10.1177/030098589803500302
  22. Stouffer RL, Grodin MS, Davis JR, Surwit EA. 1984. Investigation of binding sites for follicle-stimulating hormone and chorionic gonadotropin in human ovarian cancers. J Clin Endocrinol Metab 59: 441-446. https://doi.org/10.1210/jcem-59-3-441
  23. Vail DM, MacEwen EG. 2000. Spontaneously occurring tumors of companion animals as models for human cancer. Cancer Invest 18: 781-792. https://doi.org/10.3109/07357900009012210
  24. Weikel JH Jr, Nelson LW. 1977. Problems in evaluating chronic toxicity of contraceptive steroids in dogs. J Toxicol Environ Health 3: 167-177. https://doi.org/10.1080/15287397709529556