한국동물위생학회지 (Korean Journal of Veterinary Service)

  • 제36권2호
  • /
  • Pages.87-93
  • /
  • 2013
  • /
  • 3022-7372(pISSN)
  • /
  • 2287-7630(eISSN)
한국동물위생학회 (The Korean Society of Veterinary Service)
권호 표지
DOI QR코드

DOI QR Code

n-Hexane에 의한 삼백초 추출물의 항균 및 항바이러스 활성

Antimicrobial and antiviral activity of Saururus chinensis extract by n-Hexane

  • 이주현 (공주대학교 특수동물학과) ;
  • 최영호 (공주대학교 특수동물학과) ;
  • 박윤진 (공주대학교 특수동물학과) ;
  • 장효완 (공주대학교 특수동물학과) ;
  • 김병수 (공주대학교 특수동물학과)
  • Lee, Ju-Hyun (Department of Companion and Laboratory Animal Science, Kongju National University) ;
  • Choe, Yeong-Ho (Department of Companion and Laboratory Animal Science, Kongju National University) ;
  • Park, Yoon-Jin (Department of Companion and Laboratory Animal Science, Kongju National University) ;
  • Zhang, Xiao-Wan (Department of Companion and Laboratory Animal Science, Kongju National University) ;
  • Kim, Byeong-Soo (Department of Companion and Laboratory Animal Science, Kongju National University)
  • 투고 : 2013.02.04
  • 심사 : 2013.05.21
  • 발행 : 2013.06.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

This study was conducted to investigate the antimicrobial, antivirus properties of Saururus chinensis extracts. The n-hexane extracts from Saururus chinensis showed the active antimicrobial activity against gram-positive bacteria. Minimum inhibitory concentration (MIC) of Saururus chiensis n-hexane extracts was 1.25 mg/ml against B. subtilis and 2.5 mg/ml against S. aureus. The cytotoxicity effects on MDBK (Madin-Darby bovine kidney) cell were observed at the various n-hexane extract concentrations. In $TCID_{50}$ assay, 0.6 mg/ml of n-hexane extracts decreased BVD (bovine viral diarrhea) virus by 1.4 log, whereas other extracts did not show antiviral activity. In this study, The results suggested that n-hexane extracts and fractions of Saururus chinensis can be a candidate materal of feed additive to chemical antibiotics and antivirus substances.

키워드

참고문헌

  1. 권중안. 1999. 속 삼백초와 어성초에 대하여. 대한한약 3: 28-32.
  2. 김재길. 1984. pp. 174. 천연약물대사전. 남산당, 서울.
  3. 신민교. 1994. pp. 336-337. 임상본초학. 영림사, 서울.
  4. 이연희. 2001. 임상과 축산에서 발견되는 항생제 내성균주의 현황. 한국수의공중보건학회 25: 43-54.
  5. 정석찬. 2007. 축산 항생제내성 및 항생제 사용실태 조사. 식품의약품안전청.
  6. 진영화. 2008. 질병관리 II-소 바이러스 설사병(Bovine Viral Diahhrea, BVD), 왜 중요한가. 낙농육우회보 28: 136-138.
  7. 黃泰康. 1994. pp. 177. 常用中藥成分與藥理手冊. 中國醫藥料技出版社, 北京.
  8. Hierholzer JC, Killington RA. 1996. Virus isolation and quantitation. pp. 35-46. In: Mahy BW, Kangro. HO(ed.). Virology Methods Manual. 1st ed. Academy Press, San Diego.
  9. Jeon GH, Shin MK, Song HJ. 1998. Studies on the mechanism of nitric oxide (NO) induction in the pertoneal macrophages by Herba Saurui (HS). KOMS 19: 36-49.
  10. Jin SW, Park SJ, Shin MK, Song HJ. 1997. Rhizoma Saururi (RS) induced the morphological change of the peritoneal macrophages through nitric oxide (NO). J of Hebology 12: 131-141.
  11. Jung DS. 1992. A study on fatty acids and amino acids of Saururus Chinensis. Cheju Univ Jour (NaturalSci) 35: 111-118.
  12. Kang SK, Kim YD, Choi OJ. 1998. Antimicrobial Activity of Defatted Camellia (Camellia japonica L.) Seeds Extract. J Korean Soc Food Sci Nutr 27: 232-238.
  13. Kang SN, Kim JD, Kim IS, Jin SK, Lee MH. 2007. Effect of Replacing Antibiotics by Herb Extracts and Digestive Enzymes Containing Vitamin E and Oriental Medicinal Plants Byproduct on Blood Serum Cholesterol and Meat Qualities in the Hog Loin Meat. Korean J Food Sci Ani Resour 27: 87-94. https://doi.org/10.5851/kosfa.2007.27.1.87
  14. Kang TY, Kang ST, Ihn YH, Lee YH, Cho DY, Lee SJ, Son WG, Heo MS, Jeong DK. 2010. Prevention of Salmonella Infection in Layer Hen Fed with Microbial Fermented Citrus Shell. J of Life Sci 20: 190-196. https://doi.org/10.5352/JLS.2010.20.2.190
  15. Koh MS. 2004. Antimicrobial Activity of Saururus chinensis Baill. Extract. J Korean Soc Food Sci Nutr 33: 1098-1105. https://doi.org/10.3746/jkfn.2004.33.7.1098
  16. Kott V, Barbini L, Cruanes M, Munoz JD, Vivot E, Cruanes J, Martino V, Ferraro G, Cavallaro L, Campos R. 1999. Antiviral activity in Argentine medicinal plants. Journal of Ethnopharmacology 64: 79-84.
  17. Kwak JW, Kwon CH. 1988. Pharmacological studies on Saururus chinensis Baill. Kyung Hee University Bulletin of Kyung Hee Pharmaceutical Science 16: 137-154.
  18. Lee IS. 2001. Effect of water extract from Saururus chinensis (Lour.) Bail water extracts on the cancer cells and antioxidative activity in cytotoxicity. Korean J Postharvest Sci Technol 8: 213-216.
  19. Lee IS, Lee SG, Kim HS. 2002. Preparation and Quality Characteristics of Yogurt Added with Saururus chinensis (Lour.) Bail. J Korean Soc Food Sci Nutr 31: 411-416. https://doi.org/10.3746/jkfn.2002.31.3.411
  20. Lee SB, Kim BK, Park CH, Park GH, Jin YC, Kang HS, Kim YC, Kim YC, Bai SC, Kim SK, Choi YJ, Lee HG. 2011. Effects of Dietary Pro-biotics and Immunomodulator as an Alternative to Antibiotics in Korean Native Chicken. Journal of Animal Science and Technology 53: 409-418. https://doi.org/10.5187/JAST.2011.53.5.409
  21. Park SK, Oh GJ, Bae CI, Kim HJ, Han WS, Chung SG, Cho EW. 1997. Studies on the cytotoxic constituent of Saururus chinensis (Lour.) Baill. J Pharm Soc Korea 41: 704-708.
  22. Park BS. 2010. Effect of Dietary Antibiotic Replacement with Korean Red Pine Bark Extracts in Broiler Diets. Journal of Life Science 20: 1047-1053. https://doi.org/10.5352/JLS.2010.20.7.1047
  23. Park JH, Park BG, Kim MJ, Park SG, Kim JH. 1998. Effects of seed tuber position and number of nodes on growth of Saururus Chinensis Baill. Korean J Medicine Crop Sci 6: 286-293.
  24. Park YS, Kim JR, Kang BK, Choe YH, Kim BS. 2012. Inhibitory effects of herbal medicine on coccidiosis. Korean J Vet Serv 35: 25-31. https://doi.org/10.7853/kjvs.2012.35.1.025
  25. Seong SH. 1998. Hepatoprotective lignans of Saururus Chinensis. Seoul National University, PhD Dissertation.
  26. Wang EC, Shih MH., Liu MC, Chen MT, Lee GH. 1996. Studies of constituents of Saururus chinensis. Heterocycles 43: 969-976. https://doi.org/10.3987/COM-95-7370

피인용 문헌

  1. Antimicrobial and Antioxidant Activities of Ethanol Leaf Extract of Dendropanax morbiferus Lev. vol.31, pp.5, 2015, https://doi.org/10.9724/kfcs.2015.31.5.515
  2. 일라이트 시용량에 따른 삼백초 잎의 유효성분 및 향기성분 함량 비교 vol.22, pp.3, 2013, https://doi.org/10.7783/kjmcs.2014.22.3.188
  3. Anti-inflammatory activity of manassantin A from ultra-fine ground Saururus chinensis in lipopolysaccharide-stimulated RAW 264.7 cells vol.60, pp.1, 2017, https://doi.org/10.1007/s13765-016-0249-5