Korean Circulation Journal

  • 제43권7호
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  • Pages.481-487
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  • 2013
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  • 1738-5520(pISSN)
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  • 1738-5555(eISSN)
대한심장학회 (The Korean Society of Cardiology)
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Cardiac Rehabilitation Increases Exercise Capacity with a Reduction of Oxidative Stress

  • Fukuda, Taira (Health Center, Hitotsubashi University) ;
  • Kurano, Miwa (Department of Ischemic Circulatory Physiology, University of Tokyo) ;
  • Fukumura, Kazuya (Department of Ischemic Circulatory Physiology, University of Tokyo) ;
  • Yasuda, Tomohiro (Department of Ischemic Circulatory Physiology, University of Tokyo) ;
  • Iida, Haruko (Department of Ischemic Circulatory Physiology, University of Tokyo) ;
  • Morita, Toshihiro (Department of Ischemic Circulatory Physiology, University of Tokyo) ;
  • Yamamoto, Yumiko (Department of Cardiovascular Medicine, University of Tokyo) ;
  • Takano, Nami (Department of Cardiovascular Medicine, University of Tokyo) ;
  • Komuro, Issei (Department of Cardiovascular Medicine, University of Tokyo) ;
  • Nakajima, Toshiaki (Department of Ischemic Circulatory Physiology, University of Tokyo)
  • 발행 : 2013.07.30
⟨ 이전 논문 다음 논문 ⟩

초록

Background and Objectives: Reactive oxygen species (ROS) mediate various signaling pathways that underlie vascular inflammation in atherogenesis and cardiovascular diseases. Cardiac rehabilitation (CR) has a variety of multiple beneficial effects, including anti-inflammatory effects. The purpose of the present study was to investigate the effects of CR on ROS in patients with cardiovascular diseases. Subjects and Methods: The serum level of derivatives of reactive oxidative metabolites, an index of oxidative stress, was measured in 100 patients with cardiovascular diseases before, and, subsequently, 3 and 6 months after, CR. A biological antioxidant potential (BAP) test was applied to assess the antioxidant power of the serum. Results: The resting reactive oxidative metabolite levels decreased 3-6 months after CR Spre: $351{\pm}97$ Carratelli unit (CARR U), 3 months: $329{\pm}77$ CARR U, 6 months: $325{\pm}63$ CARR U, all p<0.01 with the increase of the percentage of the predicted values of $\dot{V}O_{2\;peak}$ and the percentage of the predicted values of $\dot{V}O_2$ at the anaerobic threshold ($\dot{V}O_{2\;AT}$) and the decrease of the B-type natriuretic peptide (BNP). The BAP test and antioxidative/oxidative stress ratio increased 6 months after CR. The % changes of the antioxidative/oxidative stress ratio was positively correlated with the % changes of $\dot{V}O_{2\;AT}$, and negatively correlated with the % changes of the BNP. Conclusion: These results suggest that intensive supervised CR significantly improved exercise capacity, which may be attributable to an adaptive response involving more efficient oxidative metabolites or the increased capacity of endogenous anti-oxidative systems in patients with cardiovascular diseases.

키워드

참고문헌

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