Korean Circulation Journal

The Korean Society of Cardiology (대한심장학회)
권호 표지
DOI QR코드

DOI QR Code

The Brachial Ankle Pulse Wave Velocity is Associated with the Presence of Significant Coronary Artery Disease but Not the Extent

  • Chae, Myung-Joon (Department of Cardiology, Sejong General Hospital) ;
  • Jung, In-Hyun (Department of Cardiology, Sejong General Hospital) ;
  • Jang, Duck-Hyun (Department of Cardiology, Sejong General Hospital) ;
  • Lee, Soo-Yeon (Department of Cardiology, Sejong General Hospital) ;
  • Hyun, Joo-Yong (Department of Cardiology, Sejong General Hospital) ;
  • Jung, Jae-Hoon (Department of Cardiology, Sejong General Hospital) ;
  • Ahn, Dae-Sung (Department of Cardiology, Sejong General Hospital) ;
  • Lim, Dal-Soo (Department of Cardiology, Sejong General Hospital) ;
  • Lee, Sook-Jin (Department of Cardiology, Sejong General Hospital)
  • Published : 2013.04.30
⟨ Previous Next ⟩

Abstract

Background and Objectives: Arterial stiffness is well known as an important risk factor for cardiovascular disease. At our institution, we assessed the association between arterial stiffness, as determined by brachial ankle pulse wave velocity (baPWV), and the extent of coronary artery disease (CAD), as detected by conventional coronary angiography (CAG) in patients who visited the outpatient clinic for angina without any previous history of heart disease. In addition, we evaluated if the level of baPWV could predict the revascularization as a clinical outcome. Subjects and Methods: On a retrospective basis, we analyzed the data of 651 consecutive patients who had undergone baPWV and elective CAG for suspected CAD between June 2010 and July 2011, at a single cardiovascular center. Results: The baPWV was one of the statistically meaningful predictors of significant CAD (diameter of stenosis >50%) in addition to male gender, age, the level of high density lipoprotein-cholesterol, and hemoglobin A1c in multivariate analysis. However, baPWV was not the significant predictor of revascularization. When the extent of CAD was classified into following 4 groups; no significant CAD, 1-, 2- and 3-vessel disease, there was significant difference of baPWV between the significant and non-significant CAD group, but there was no difference of baPWV among the 3 significant CAD groups, although there was a trend toward the positive correlation. Conclusion: Although baPWV was an independent predictor of significant CAD, it was neither associated significantly with the extent of CAD nor with the risk of revascularization. Therefore, baPWV has a limited value for portending the severity of CAD in patients with chest pain.

Keywords

References

  1. Amar J, Ruidavets JB, Chamontin B, Drouet L, Ferrieres J. Arterial stiffness and cardiovascular risk factors in a population-based study. J Hypertens 2001;19:381-7. https://doi.org/10.1097/00004872-200103000-00005
  2. Vlachopoulos C, Aznaouridis K, Stefanadis C. Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis. J Am Coll Cardiol 2010;55:1318-27. https://doi.org/10.1016/j.jacc.2009.10.061
  3. Mitchell GF, Hwang SJ, Vasan RS, et al. Arterial stiffness and cardiovascular events: the Framingham Heart Study. Circulation 2010;121:505-11. https://doi.org/10.1161/CIRCULATIONAHA.109.886655
  4. Lehmann ED, Gosling RG, Sonksen PH. Arterial wall compliance in diabetes. Diabet Med 1992;9:114-9. https://doi.org/10.1111/j.1464-5491.1992.tb01746.x
  5. London GM, Marchais SJ, Safar ME, et al. Aortic and large artery compliance in end-stage renal failure. Kidney Int 1990;37:137-42. https://doi.org/10.1038/ki.1990.19
  6. Nam HJ, Jung IH, Kim J, et al. Association between brachial-ankle pulse wave velocity and occult coronary artery disease detected by multidetector computed tomography. Int J Cardiol 2012;157:227-32. https://doi.org/10.1016/j.ijcard.2011.01.045
  7. Kullo IJ, Bielak LF, Turner ST, Sheedy PF 2nd, Peyser PA. Aortic pulse wave velocity is associated with the presence and quantity of coronary artery calcium: a community-based study. Hypertension 2006;47:174-9. https://doi.org/10.1161/01.HYP.0000199605.35173.14
  8. Laurent S, Boutouyrie P, Asmar R, et al. Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension 2001;37:1236-41. https://doi.org/10.1161/01.HYP.37.5.1236
  9. Yamashina A, Tomiyama H, Takeda K, et al. Validity, reproducibility, and clinical significance of noninvasive brachial-ankle pulse wave velocity measurement. Hypertens Res 2002;25:359-64. https://doi.org/10.1291/hypres.25.359
  10. Kim HJ, Nam JS, Park JS, et al. Usefulness of brachial-ankle pulse wave velocity as a predictive marker of multiple coronary artery occlusive disease in Korean type 2 diabetes patients. Diabetes Res Clin Pract 2009;85:30-4. https://doi.org/10.1016/j.diabres.2009.03.013
  11. Yamashina A, Tomiyama H, Arai T, et al. Brachial-ankle pulse wave velocity as a marker of atherosclerotic vascular damage and cardiovascular risk. Hypertens Res 2003;26:615-22. https://doi.org/10.1291/hypres.26.615
  12. Liu CS, Li CI, Shih CM, et al. Arterial stiffness measured as pulse wave velocity is highly correlated with coronary atherosclerosis in asymptomatic patients. J Atheroscler Thromb 2011;18:652-8. https://doi.org/10.5551/jat.7021
  13. Xu Y, Wu Y, Li J, et al. The predictive value of brachial-ankle pulse wave velocity in coronary atherosclerosis and peripheral artery diseases in urban Chinese patients. Hypertens Res 2008;31:1079-85. https://doi.org/10.1291/hypres.31.1079
  14. Imanishi R, Seto S, Toda G, et al. High brachial-ankle pulse wave velocity is an independent predictor of the presence of coronary artery disease in men. Hypertens Res 2004;27:71-8. https://doi.org/10.1291/hypres.27.71
  15. Kingwell BA, Waddell TK, Medley TL, Cameron JD, Dart AM. Large artery stiffness predicts ischemic threshold in patients with coronary artery disease. J Am Coll Cardiol 2002;40:773-9. https://doi.org/10.1016/S0735-1097(02)02009-0
  16. Mancia G, De Backer G, Dominiczak A, et al. 2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens 2007;25:1105-87. https://doi.org/10.1097/HJH.0b013e3281fc975a
  17. Asmar R, Benetos A, Topouchian J, et al. Assessment of arterial distensibility by automatic pulse wave velocity measurement. Validation and clinical application studies. Hypertension 1995;26:485-90. https://doi.org/10.1161/01.HYP.26.3.485
  18. Asmar R, Topouchian J, Pannier B, et al. Pulse wave velocity as endpoint in large-scale intervention trial. The Complior study. Scientific, Quality Control, Coordination and Investigation Committees of the Complior Study. J Hypertens 2001;19:813-8. https://doi.org/10.1097/00004872-200104000-00019
  19. Safar ME, Henry O, Meaume S. Aortic pulse wave velocity: an independent marker of cardiovascular risk. Am J Geriatr Cardiol 2002;11:295-8.
  20. Mattace-Raso FU, van der Cammen TJ, Hofman A, et al. Arterial stiffness and risk of coronary heart disease and stroke: the Rotterdam Study. Circulation 2006;113:657-63. https://doi.org/10.1161/CIRCULATIONAHA.105.555235
  21. Tomiyama H, Koji Y, Yambe M, et al. Brachial -- ankle pulse wave velocity is a simple and independent predictor of prognosis in patients with acute coronary syndrome. Circ J 2005;69:815-22. https://doi.org/10.1253/circj.69.815
  22. Tsuchikura S, Shoji T, Kimoto E, et al. Brachial-ankle pulse wave velocity as an index of central arterial stiffness. J Atheroscler Thromb 2010;17:658-65. https://doi.org/10.5551/jat.3616
  23. Tomiyama H, Yamashina A, Arai T, et al. Influences of age and gender on results of noninvasive brachial-ankle pulse wave velocity measurement--a survey of 12517 subjects. Atherosclerosis 2003;166:303-9. https://doi.org/10.1016/S0021-9150(02)00332-5
  24. Yambe M, Tomiyama H, Hirayama Y, et al. Arterial stiffening as a possible risk factor for both atherosclerosis and diastolic heart failure. Hypertens Res 2004;27:625-31. https://doi.org/10.1291/hypres.27.625
  25. Boutouyrie P, Tropeano AI, Asmar R, et al. Aortic stiffness is an independent predictor of primary coronary events in hypertensive patients: a longitudinal study. Hypertension 2002;39:10-5. https://doi.org/10.1161/hy0102.099031
  26. Demer LL. Effect of calcification on in vivo mechanical response of rabbit arteries to balloon dilation. Circulation 1991;83:2083-93. https://doi.org/10.1161/01.CIR.83.6.2083
  27. Seo WW, Chang HJ, Cho I, et al. The value of brachial-ankle pulse wave velocity as a predictor of coronary artery disease in high-risk patients. Korean Circ J 2010;40:224-9. https://doi.org/10.4070/kcj.2010.40.5.224
  28. Igarashi Y, Chikamori T, Tomiyama H, et al. Diagnostic value of simultaneous brachial and ankle blood pressure measurements for the extent and severity of coronary artery disease as assessed by myocardial perfusion imaging. Circ J 2005;69:237-42. https://doi.org/10.1253/circj.69.237

Cited by

  1. Increased pulse wave velocity and augmentation index after isometric handgrip exercise in patients with coronary artery disease vol.21, pp.None, 2013, https://doi.org/10.1186/s40885-015-0016-7
  2. The Relationship between Pulse Wave Velocity and Coronary Artery Stenosis and Percutaneous Coronary Intervention: a retrospective observational study vol.17, pp.None, 2013, https://doi.org/10.1186/s12872-017-0476-7
  3. Relationship between brachial-ankle pulse wave velocity and invasively measured aortic pulse pressure vol.20, pp.3, 2013, https://doi.org/10.1111/jch.13200
  4. Pulse Wave Velocity in Atherosclerosis vol.6, pp.None, 2013, https://doi.org/10.3389/fcvm.2019.00041
  5. The relationship between the prevalence and complexity of coronary artery disease and aortic stiffness in myocardial infarction patients without ST-segment elevation vol.6, pp.1, 2013, https://doi.org/10.4103/ijca.ijca_46_19