Korean Circulation Journal

  • 제43권2호
  • /
  • Pages.73-79
  • /
  • 2013
  • /
  • 1738-5520(pISSN)
  • /
  • 1738-5555(eISSN)
대한심장학회 (The Korean Society of Cardiology)
권호 표지
DOI QR코드

DOI QR Code

Arterial Ageing

  • Lee, Seung-Jun (Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine) ;
  • Park, Sung-Ha (Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine)
  • 발행 : 2013.02.28
⟨ 이전 논문 다음 논문 ⟩

초록

Arterial ageing is characterized by age associated degeneration and sclerosis of the media layer of the large arteries. However, besides ageing, clinical conditions, which enhance oxidative stress and inflammation act to accelerate the degree of arterial ageing. In this review, we summarized the pathophysiology and contributing factors that accelerate arterial ageing. Among them, we focused on hypertension, the renin-angiotensin-aldosterone system and vascular inflammation which are modifiable causes of the arterial ageing process. Also, novel treatment targets derived from the disease models such as the Hutchinson Gilford Progeria Syndrome were reviewed.

키워드

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