생체재료학회지 (Biomaterials Research)

  • 제17권1호
  • /
  • Pages.37-40
  • /
  • 2013
  • /
  • 1226-4601(pISSN)
  • /
  • 2055-7124(eISSN)
한국생체재료학회 (Korean Society for Biomaterials)
권호 표지

히알루론산 하이드로겔의 가교도에 따른 함수특성

Swelling Properties for Cross-linking Degree of Hyaluronic Acid Hydrogels

  • 김진태 (충북대학교 신소재공학과) ;
  • 이득용 (대림대학교 재료정보과) ;
  • 오유성 (충북보건과학대학교 의기공과) ;
  • 방중완 (서울과학기술대학교 신소재공학과) ;
  • 현창용 (서울과학기술대학교 신소재공학과) ;
  • 김태형 (강원대학교 방사선학과) ;
  • 최재하 (충북대학교 신소재공학과)
  • Kim, Jin Tae (Department of Advanced Material Engineering, Chungbuk National University) ;
  • Lee, Deuk Yong (Department of Materials Engineering, Daelim University) ;
  • Oh, Yoo Seoung (Department of Prosthetics and Orthotics, Chungbuk Health & Science University) ;
  • Bang, Jung Wan (Department of Advanced Material Engineering, Seoul National University) ;
  • Hyun, Chang-Yong (Department of Advanced Material Engineering, Seoul National University) ;
  • Kim, Tae-Hyung (Department of Radiological Science, Kangwon National University) ;
  • Choi, Jae Ha (Department of Advanced Material Engineering, Chungbuk National University)
  • 발행 : 2013.03.01
⟨ 이전 논문 다음 논문 ⟩

초록

Hyaluronic acid (HA) hydrogels were crosslinked by dropping of sodium hyaluronate solutions into a solution mixture of divinyl sulfone (DVS) dissolved in 2-methyl-1-propanol. Then cleaning for residual unreacted DVS, and drying at $60^{\circ}C$, 20torr vacuum. The experimental conditions are crosslinking temperature (CLT), crosslinking agent concentration (CAC), respectively. And then parametric studied the morphology, the porosity, the swelling ratio of the hydrogels. The swelling ratio and pore size were decreased as the degree of crosslink was increased. They can be controlled by adjusting the by varying CLT and CAC.

키워드

참고문헌

  1. Y. Luo, K. R. Kelly, and G. D. Prestwich, "Cross-linked hyaluronic acid hydrogel films: new biomateirals for drug delivery," J. of Controlled Release, 69, 169-184 (2000). https://doi.org/10.1016/S0168-3659(00)00300-X
  2. X. Z. Shu, Y. Liu, Y. Luo, M. C. Roberts, and G. D. Prestwich, "Disulfied Cross-Linked Hyaluronan Hydrogels," Biomacromolecules, 3, 1304-1311 (2002). https://doi.org/10.1021/bm025603c
  3. J. T. Kim, J, H. Choi, and D. Y. Lee, "Pyrogenicity of hyaluronic acid hydrogel cross-linked by divinyl sulfone for soft tissue augmentation," Natural Science, 2, 764-768 (2010). https://doi.org/10.4236/ns.2010.27096
  4. S. K. Hahn, J. K. Park, T. Tomimatsu, and T. Shimoboji, "Synthesis and degradation test of hyaluronic acid hydrogels," Int J Biol Macromol, 40, 374-380, (2007). https://doi.org/10.1016/j.ijbiomac.2006.09.019
  5. K. Tomihata and Y. Ikada, "Preparation of cross-linked hyaluronic acid films of low water content," Biomaterials, 18, 189-195 (1997). https://doi.org/10.1016/S0142-9612(96)00116-0
  6. J. T. Kim, D. Y. Lee, and J. H. Choi, "Preparation and Characterization of Hyaluronic Acid Microbeads," Biomaterials Research, 14, 157-160 (2010).
  7. S. P. Zhong, D. Campoccia, P. J. Doherty, R. L. Williams, L. Benedetti, and D. F. Williams, "Biodegradation of hyaluronic acid derivative by hyaluronidase," Biomaterials. 15, 359-365 (1994). https://doi.org/10.1016/0142-9612(94)90248-8
  8. Y. Tokita and A. Okamoto, "Hydrolytic degradation of hyaluronic acid," Polymer Degradation and Stalility. 48, 269-273 (1995). https://doi.org/10.1016/0141-3910(95)00041-J
  9. J. T. Kim and J. H. Choi, "Production and Evaluation of Hyaluronic Acid Gel for Soft Tissue Augmentation," Biomaterials Research, 13, 105-108 (2009).
  10. J. M. Rodriguez-Diaz and M. T. Santos-Martin, "Study of the best designs for modifications of the Arrhenius equation," Chemometrics and Intelligent Laboratory Systems, 95, 199-208 (2009). https://doi.org/10.1016/j.chemolab.2008.10.011
  11. J. Y. Kwon and S. I. Cheong, "Synthesis and Characteristics of Hyaluronic Acid Bead Crosslinked by 1,3-Butadiene diepoxide," Polymer(Korea), 29, 445-450 (2005).
  12. C. B. Shah and S. M. Barnett, "Swelling Behavior of Hyaluronic Acid Gels," J. of Applied Polymer Science, 45, 293-298 (1992). https://doi.org/10.1002/app.1992.070450211
  13. F. A. Korkoosh, J. Brussee, J. C. V. F. Borchard, M. Rafiee-Tehrani, and H. E. Junginger, "Preparation and NMR characterization of superporous hydrogels (SPH) and SPH composites," Polymer, 41, 8213-8220 (2000). https://doi.org/10.1016/S0032-3861(00)00200-7
  14. J. Chen, H. Park, and K. Park, "Synthesis of superporous hydrogels: Hydrogels with fast swelling and superabsorbent properties," J. of Biomed. Mater. Res., 44, 53-62 (1999). https://doi.org/10.1002/(SICI)1097-4636(199901)44:1<53::AID-JBM6>3.0.CO;2-W
  15. R. A. Gemeinhart, H. Park and K. Park, "Pore Structure of Superporous Hydrogels," Polymers for Advanced Technologies, 11, 617-625 (2000). https://doi.org/10.1002/1099-1581(200008/12)11:8/12<617::AID-PAT12>3.0.CO;2-L