Biomaterials Research (생체재료학회지)

Korean Society for Biomaterials (한국생체재료학회)
권호 표지

Preparation and Characterization of Hydrophilized Porous Polycaprolactone-encapsulated Alginate Microsphere for the Treatment of Diabetes Mellitus

당뇨병 치료를 위한 친수화된 다공성 폴리카프로락톤 캡슐 알지네이트 미세입자의 제조 및 분석

  • Kim, Eun Ji (Department of Advanced Materials, Hannam University) ;
  • Choi, Soo Jung (Department of Advanced Materials, Hannam University) ;
  • Kim, Tae Ho (Department of Advanced Materials, Hannam University) ;
  • Oh, Se Heang (Department of Nanobiomedical Science & WCU Research Center, Dankook University) ;
  • Lee, Jin Ho (Department of Advanced Materials, Hannam University)
  • 김은지 (한남대학교 신소재공학과) ;
  • 최수정 (한남대학교 신소재공학과) ;
  • 김태호 (한남대학교 신소재공학과) ;
  • 오세행 (단국대학교 나노바이오의과학과 & WCU 나노바이오 의과학연구센터) ;
  • 이진호 (한남대학교 신소재공학과)
  • Published : 2013.03.01
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Abstract

Diabetes mellitus is a group of metabolic diseases in which a person has high blood sugar, either because the body does not produce enough insulin, or because cells do not respond to the insulin. Translation of islets has been proposed as a safe and effective therapeutic technique. The islets are commonly encapsulated in alginate/poly(l-lysine) (PLL) hydrogel to suppress the host immune response. However, the low islet isolation efficacy caused by the weak mechanical property of the alginate/PLL hydrogel which can allow hydrogel rupture and thus expose of islet to host immune system is remained a critical limitation for clinical application. To overcome this problem, we developed a hydrophilized porous polycaprolactone (PCL)-encapsulated alginate microsphere by an immersion precipitation of alginate microsphere into PCL/Pluronic F127 solution. Their morphology, mechanical stability in the PBS, protein adsorption behavior, insulin release profile and cytotoxicity were compared with conventional alginate/PLL microsphere.

Keywords

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