Korean Journal of Radiology

The Korean Society of Radiology (대한영상의학회)
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Glioma Grading Capability: Comparisons among Parameters from Dynamic Contrast-Enhanced MRI and ADC Value on DWI

  • Choi, Hyun Seok (Department of Radiology, Severance Hospital, Yonsei University College of Medicine) ;
  • Kim, Ah Hyun (Department of Radiology, Severance Hospital, Yonsei University College of Medicine) ;
  • Ahn, Sung Soo (Department of Radiology, Severance Hospital, Yonsei University College of Medicine) ;
  • Shin, Na-Young (Department of Radiology, Severance Hospital, Yonsei University College of Medicine) ;
  • Kim, Jinna (Department of Radiology, Severance Hospital, Yonsei University College of Medicine) ;
  • Lee, Seung-Koo (Department of Radiology, Severance Hospital, Yonsei University College of Medicine)
  • Published : 2013.06.01
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Abstract

Objective: Permeability parameters from dynamic contrast-enhanced MRI (DCE-MRI) and apparent diffusion coefficient (ADC) value on diffusion-weighted imaging (DWI) can be quantitative physiologic metrics for gliomas. The transfer constant ($K^{trans}$) has shown efficacy in grading gliomas. Volume fraction of extravascular extracellular space ($v_e$) has been underutilized to grade gliomas. The purpose of this study was to evaluate $v_e$ in its ability to grade gliomas and to assess the correlation with other permeability parameters and ADC values. Materials and Methods: A total of 33 patients diagnosed with pathologically-confirmed gliomas were examined by 3 T MRI including DCE-MRI and ADC map. A region of interest analyses for permeability parameters from DCE-MRI and ADC were performed on the enhancing solid portion of the tumors. Permeability parameters form DCE-MRI and ADC between low- and high-grade gliomas; the diagnostic performances of presumptive metrics and correlation among those metrics were statistically analyzed. Results: High-grade gliomas showed higher $K^{trans}$ (0.050 vs. 0.010 in median value, p = 0.002) and higher $v_e$ (0.170 vs. 0.015 in median value, p = 0.001) than low-grade gliomas. Receiver operating characteristic curve analysis showed significance in both $K^{trans}$ and $v_e$ for glioma grading. However, there was no significant difference in diagnostic performance between $K^{trans}$ and ve. ADC value did not correlate with any of the permeability parameters from DCE-MRI. Conclusion: Extravascular extracellular space ($v_e$) appears to be comparable with transfer constant ($K^{trans}$) in differentiating high-grade gliomas from low-grade gliomas. ADC value does not show correlation with any permeability parameters from DCE-MRI.

Keywords

References

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