Korean Journal of Radiology

The Korean Society of Radiology (대한영상의학회)
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Application of 31P MR Spectroscopy to the Brain Tumors

  • Ha, Dong-Ho (Department of Radiology, College of Medicine, Dong-A University) ;
  • Choi, Sunseob (Department of Radiology, College of Medicine, Dong-A University) ;
  • Oh, Jong Young (Department of Radiology, College of Medicine, Dong-A University) ;
  • Yoon, Seong Kuk (Department of Radiology, College of Medicine, Dong-A University) ;
  • Kang, Myong Jin (Department of Radiology, College of Medicine, Dong-A University) ;
  • Kim, Ki-Uk (Department of Neurosurgery, College of Medicine, Dong-A University)
  • Published : 2013.06.01
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Abstract

Objective: To evaluate the clinical feasibility and obtain useful parameters of 31P magnetic resonance spectroscopy (MRS) study for making the differential diagnosis of brain tumors. Materials and Methods: Twenty-eight patients with brain tumorous lesions (22 cases of brain tumor and 6 cases of abscess) and 11 normal volunteers were included. The patients were classified into the astrocytoma group, lymphoma group, metastasis group and the abscess group. We obtained the intracellular pH and the metabolite ratios of phosphomonoesters/ phosophodiesters (PME/PDE), PME/inorganic phosphate (Pi), PDE/Pi, PME/adenosine triphosphate (ATP), PDE/ATP, PME/ phosphocreatine (PCr), PDE/PCr, PCr/ATP, PCr/Pi, and ATP/Pi, and evaluated the statistical significances. Results: The brain tumors had a tendency of alkalization (pH = 7.28 ${\pm}$ 0.27, p = 0.090), especially the pH of the lymphoma was significantly increased (pH = 7.45 ${\pm}$ 0.32, p = 0.013). The brain tumor group showed increased PME/PDE ratio compared with that in the normal control group (p = 0.012). The ratios of PME/PDE, PDE/Pi, PME/PCr and PDE/PCr showed statistically significant differences between each brain lesion groups (p < 0.05). The astrocytoma showed an increased PME/PDE and PME/PCr ratio. The ratios of PDE/Pi, PME/PCr, and PDE/PCr in lymphoma group were lower than those in the control group and astrocytoma group. The metastasis group showed an increased PME/PDE ratio, compared with that in the normal control group. Conclusion: We have obtained the clinically applicable 31P MRS, and the pH, PME/PDE, PDE/Pi, PME/PCr, and PDE/PCr ratios are helpful for differentiating among the different types of brain tumors.

Keywords

References

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