The Korean journal of internal medicine

  • 제28권4호
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  • Pages.428-438
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  • 2013
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  • 1226-3303(pISSN)
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  • 2005-6648(eISSN)
대한내과학회 (The Korean Association of Internal Medicine)
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Factors influencing hepatocellular carcinoma prognosis after hepatectomy: a single-center experience

  • Park, Sung Keun (Department of Internal Medicine, Gachon University Gil Medical Center) ;
  • Jung, Young Kul (Department of Internal Medicine, Gachon University Gil Medical Center) ;
  • Chung, Dong Hae (Department of Pathology, Gachon University Gil Medical Center) ;
  • Kim, Keon Kuk (Department of Surgery, Gachon University Gil Medical Center) ;
  • Park, Yeon Ho (Department of Surgery, Gachon University Gil Medical Center) ;
  • Lee, Jung Nam (Department of Surgery, Gachon University Gil Medical Center) ;
  • Kwon, Oh Sang (Department of Internal Medicine, Gachon University Gil Medical Center) ;
  • Kim, Yun Soo (Department of Internal Medicine, Gachon University Gil Medical Center) ;
  • Choi, Duck Joo (Department of Internal Medicine, Gachon University Gil Medical Center) ;
  • Kim, Ju Hyun (Department of Internal Medicine, Gachon University Gil Medical Center)
  • 발행 : 2013.07.01
⟨ 이전 논문 다음 논문 ⟩

초록

Background/Aims: Recurrence after hepatic resection is one of the most important factors impacting the prognosis and survival of patients with hepatocellular carcinoma (HCC). We identified prognostic factors affecting overall survival (OS) and disease-free survival (DFS) in patients with HCC after hepatic resection. Methods: This study was of a retrospective cohort design, and 126 patients who underwent hepatic resection for HCC at Gachon University Gil Medical Center between January 2005 and December 2010 were enrolled. Various clinical, laboratory, and pathological data were evaluated to determine the prognostic factors affecting OS and DFS. Results: Two- and 4-year OS and 2- and 4-year DFS were 78.1% and 65% and 51.1% and 26.6%, respectively. In a multivariate analysis, preoperative ${\alpha}$-fetoprotein (>400 ng/mL), tumor size (${\geq}$ 5 cm), multiple tumors (two or more nodules), presence of portal vein invasion, modified Union for International Cancer Control (UICC) stage III/IV, and Barcelona Clinic Liver Cancer (BCLC) stage B/C were independent prognostic factors affecting a shorter OS. In the multivariate analysis, presence of microvascular invasion, modified UICC stage III/IV, and BCLC stage B/C were independent prognostic factors for a shorter DFS. Conclusions: The presence of vascular invasion was an independent poor prognostic factor for OS and DFS in patients with HCC after hepatic resection. Thus, close postoperative surveillance for early detection of recurrence and additional treatments are urgently needed in patients with vascular invasion after hepatic resection.

키워드

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