The Korean journal of internal medicine

  • 제28권3호
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  • Pages.352-355
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  • 2013
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  • 1226-3303(pISSN)
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  • 2005-6648(eISSN)
대한내과학회 (The Korean Association of Internal Medicine)
권호 표지
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A case of hemophagocytic syndrome in a patient with fulminant ulcerative colitis superinfected by cytomegalovirus

  • Mun, Jun Il (Department of Gastroenterology, Ajou University School of Medicine) ;
  • Shin, Sung Jae (Department of Gastroenterology, Ajou University School of Medicine) ;
  • Yu, Byung Hyun (Department of Gastroenterology, Ajou University School of Medicine) ;
  • Koo, Jee Hoon (Department of Gastroenterology, Ajou University School of Medicine) ;
  • Kim, Dong Hoon (Department of Gastroenterology, Ajou University School of Medicine) ;
  • Lee, Ki Myoung (Department of Gastroenterology, Ajou University School of Medicine) ;
  • Lee, Kwang Jae (Department of Gastroenterology, Ajou University School of Medicine)
  • 발행 : 2013.05.01
⟨ 이전 논문 다음 논문 ⟩

초록

Hemophagocytic syndrome (HPS) is an uncommon hematological disorder that manifests as fever, splenomegaly, and jaundice, with hemophagocytosis in the bone marrow and other tissues pathologically. Secondary HPS is associated with malignancy and infection, especially viral infection. The prevalence of cytomegalovirus (CMV) infection in ulcerative colitis (UC) patients is approximately 16%. Nevertheless, HPS in UC superinfected by CMV is very rare. A 52-year-old female visited the hospital complaining of abdominal pain and hematochezia for 6 days. She was diagnosed with UC 3 years earlier and had been treated with sulfasalazine, but had stopped her medication 4 months earlier. On admission, her spleen was enlarged. The peripheral blood count revealed pancytopenia and bone marrow aspiration smears showed hemophagocytosis. Viral studies revealed CMV infection. She was treated successfully with ganciclovir. We report this case with a review of the related literature.

키워드

참고문헌

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피인용 문헌

  1. Hemophagocytic lymphohistiocytosis in adults vol.67, pp.suppl, 2013, https://doi.org/10.4097/kjae.2014.67.s.s115
  2. Haemophagocytic lymphohistiocytosis in inflammatory bowel disease with virus infection vol.10, pp.2, 2013, https://doi.org/10.5114/pg.2015.48995
  3. Secondary Hemophagocytosis in Propionic Acidemia vol.25, pp.3, 2013, https://doi.org/10.5812/ijp.25(3)2015.339
  4. Toward an Algorithm for the Diagnosis and Management of CMV in Patients with Colitis vol.22, pp.12, 2013, https://doi.org/10.1097/mib.0000000000000958
  5. Approach to cytomegalovirus infections in patients with ulcerative colitis vol.32, pp.3, 2013, https://doi.org/10.3904/kjim.2017.087
  6. Hemophagocytic Lymphohistiocytosis and Inflammatory Bowel Disease: Case Report and Systematic Review vol.5, pp.2, 2013, https://doi.org/10.1159/000506514