Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Optimization of the Reaction Conditions for Synthesis of 3-(Aryloxy)quinoline Derivatives via Friedländer's Cyclization Reaction

  • Received : 2013.01.09
  • Accepted : 2013.03.31
  • Published : 2013.06.20
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Abstract

6,7-Dimethoxy-2-methyl-3-(4-nitrophenoxy)quinoline was synthesized by Friedl$\ddot{a}$nder's cyclization reaction. Different bases and solvents were tested in order to optimize the reaction conditions. The highest yields were obtained using piperidine in refluxing ethanol. Further reactions were carried out in order to prepare different diarylamide and diarylurea derivatives in moderate to high yields in order to examine their anticancer activities.

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References

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Cited by

  1. ChemInform Abstract: Optimization of the Reaction Conditions for Synthesis of 3-(Aryloxy)quinoline Derivatives via Friedlaender′s Cyclization Reaction. vol.44, pp.41, 2013, https://doi.org/10.1002/chin.201341169