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Effect of Carthami Semen and Jogyeongjongok-Tang On Pregnant Rats

홍화자(紅花子)와 조경종옥탕(調經種玉湯)이 임신 흰쥐에 미치는 영향

  • Kim, Daejun (Department of Korean Medicine, Daegu Haany University) ;
  • Seo, Buil (Department of Korean Medicine, Daegu Haany University)
  • 김대준 (대구한의대학교 한의과대학) ;
  • 서부일 (대구한의대학교 한의과대학)
  • Received : 2013.04.11
  • Accepted : 2013.05.13
  • Published : 2013.05.30

Abstract

Objectives : The present study has been undertaken to investigate the effects of Carthami Semen and Jogyeongjongok-Tang on pregnant rats. Method : In this experiment, the pregnant rats were administered by water extracts of Carthami Semen and Jogyeongjongok-Tang. The levels of weights, ALT, AST, ALP, BUN, creatinine, progesterone, Na and K in serum and reproductive indices of the rats were measured after treatment. Results : The levels of body weight gains were not significantly changed in comparison with Control group in Carthami Semen group and Jogyeongjongok-Tang group. In the levels of reproductive indices of the rats, the number of corpora lutea, implantation and viable fetuses, post-implantation loss, fetal weight and placental wight were not significantly changed in comparison with Control group in Carthami Semen group and Jogyeongjongok-Tang group. But pre-implantation loss was significantly increased in comparison with Control group in Carthami Semen group. The levels of BUN, creatine, ALT, AST and ALP were not significantly changed in comparison with Control group in Carthami Semen group and Jogyeongjongok-Tang group. The level of progesterone was not significantly changed in comparison with Control group in Carthami Semen group and Jogyeongjongok-Tang group. The levels of Na and K were not significantly changed in comparison with Control group in Carthami Semen group and Jogyeongjongok-Tang group. Conclusion : Reviewing these experimetal results, it appeared that Carthami Semen and Jogyeongjongok-Tang had not toxicity on pregnant rats.

Keywords

References

  1. The compilation committee of Oriental Gynecology. Oriental Gynecology(II). Seoul : Jeongdam. 2002 : 68.
  2. Song BK, Kang HS, Jung JT. A literature search on contraindication drug during the period of pregnancy. J Oriental Gynecol. 1987 ; 1(1) : 47-68.
  3. The textbook compilation committee of Korean herbology. Korean herbology. Seoul : Younglimsa. 2004 : 102, 1991.
  4. Yoo KH, Kim CM, Park RJ, Choi HI. A study on medical prescription referring to contraindication drug during the period of pregnancy. J Korean Qigong Med Soc. 2006 ; 9(1) : 49-69.
  5. Seo BI, Jung GY. The easily understandable herbology. revision. Daegu : publishing department of Daegu Haany University. 2007 : 295.
  6. Huh Joon(writing), translating department of oriental medical books(translator). New translation printed side by side with original Dongeuibogam. Seoul : Beopinmoonhwasa. 2007 : 1642.
  7. Shin JY. Comment on Bangyakhappyeon. Seoul : Seongbosa. 1989 : 83-4.
  8. Hwang DY, Shin MK․editorial department of Younglimsa. New supplement edition of Bangyakhappyeon. Seoul : Younglimsa. 2002 : 173.
  9. Fujinaga M, Mazze RI. Reproductive and teratogenic effects of lidocaine in Sprague-Dawley rats. Anesthesiology. 1986 ; 65 : 626-32. https://doi.org/10.1097/00000542-198612000-00010
  10. Kanai Izmi. The editorial department of Komoonsa. The manual about clinical tests(3rd edition). Seoul : Komoonsa. 1993 : 404-13, 472-80, 489-503, 524-9, 630.
  11. Xinwenfengchubangongsi. Xinbianzhongyaodaicidian (II). Taibei : Xinwenfengchubangongsi. Zhonghuaminguo. 71 : 1318-9.
  12. Susong zhuan, Hunaizhang, Wangzhipu jizhu. Tujingbencao(jifuben). fujian : fujiankexuejishuchubanshe. 1993 : 221.
  13. Jung KH, Jeong CS. Protective Effect of Carthamus tinctorius L. Semen on Hepatotoxieity by Carbon Tetrachloride in Rats. J Appl Pharmacol. 1996 ; 4(4) : 428-36.
  14. Jeong CS, KW, Jeong JS. Hepatoprotective Effect of Subfractions of Carthamus tinctorius L. Semen on the Reversal of Biotransformation Enzyme Activities in CCl4-induced Hepatotoxic Rats. J Food Hyg Saf. 1999 ; 14(2) : 172-8.
  15. Kim MR, Yang CH, Seo BI. Effects of Safflower Seeds on Bone Mineral Density in Ovariectomy-Induced Postmenopausal Osteoporotic Rats. Kor J herbology. 1998 ; 13(2) : 37-43.
  16. Kim MR, Seo BI, Yang JH. Effects of Safflower Seeds Extract on Serum Sex Hormone Levels in Ovariectomized Rats. Kor J herbology. 2003 ; 18(3) : 33-9.
  17. Seung KR, Jung KH. Effect of Carthamus tinctorius L. Semen on Endotoxin-induced Thrombosis in Rats. J Appl Pharmacol. 2001 ; 9(4) : 258-62.
  18. Seo BI, Lee ES, Park JH, Kim SC, Byun BH, Choi HY. A efficacy of Korean and Chinese Carthami Semen on analgesic effect, anti-inflammation and arthritis. Kor J herbology. 2001 ; 16(1) : 1-10.
  19. Seo YJ, Kim JH, Kim CW, Yoo SK. Effects of Jokyungjongoktang on the ovulation in rats. J Oriental Gynecol. 1999 ; 12(2) : 101-16.
  20. Bae JK, Kim GW. Effect of Jokyungiongoktang on the Fluctuation of Gonadotropin and Sex Hormone Concentration. Dongguk J Inst Oriental Med. 1992 ; 1 : 15-54.
  21. Kim SH, Chung MK, Han SS, Roh JK. Reproductive Toxicological Basic Data of Ktc:Sprague-Dawley Rats. Laboratory Animal Research. 1992 ; 8(1) : 67-72.
  22. Khera KS. Maternal toxicity--a possible factor in fetal malformations in mice. Teratology. 1984 ; 29(3) : 411-6. https://doi.org/10.1002/tera.1420290312
  23. Khera KS. Maternal toxicity:a possible etiological factor in embryo-fetal deaths and fetal malformations of rodent-rabbit species. Teratology. 1985 ; 31(1) : 129-53. https://doi.org/10.1002/tera.1420310115
  24. Johnson WE. Fetal loss from anesthesia and surgical trauma in the rabbit. Toxicol Appl Pharmacol. 1971 ; 18(4) : 773-9. https://doi.org/10.1016/0041-008X(71)90229-8
  25. Yi KN, Rhee CS. Clinical pathology file. Seoul : Euihakmunhwasa. 1996 : 82-4, 86-8, 229-32, 278-82, 489-90.