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센서 어레이를 사용한 COPD 환자의 호기분석

Analysis of COPD Patient's Exhaled Breath Using Sensor Array

  • 유준부 (경북대학교 생명의학연구소) ;
  • 이신엽 (경북대학교 병원) ;
  • 전진영 (강원대학교 전자정보통신공학부) ;
  • 변형기 (강원대학교 전자정보통신공학부) ;
  • 임정옥 (경북대학교 생명의학연구소)
  • Yu, Joon-Boo (Bio-Medical Research Institute, Kyungpook National Unversity) ;
  • Lee, Shin-Yup (Department of Internal Medicine, School of Medicine, Kyungpook National University) ;
  • Jeon, Jin-Young (Department of Electronic, Information & Communication Engineering, Kangwon National University) ;
  • Byun, Hyung-Gi (Department of Electronic, Information & Communication Engineering, Kangwon National University) ;
  • Lim, Jeong-Ok (Bio-Medical Research Institute, Kyungpook National Unversity)
  • 투고 : 2013.05.06
  • 심사 : 2013.05.20
  • 발행 : 2013.05.31

초록

The exhaled breath contains gases generated from human body. When disease occurs in the body, exhaled breath may include gas components released from disease metabolism. If we can find specific elements through analysis of the exhaled gases, this approach is an effective way to diagnose the disease. The lung function has a close relationship with exhalation. Exhaled gases from COPD (Chronic Obstructive Pulmonary Disease) patients can be analyzed by gas chromatography-mass spectroscopy (GC-MS) and a gas sensor system. The exhaled breath for healthy person and COPD patients had different components. Significantly more benzendicarboxylic acid was detected from COPD patients than in healthy persons. In addition, patients had a variety of decane. Phosphorous compounds with different isomers were detected from patients. The results obtained by gas sensor system were processed by PCA (Principal Component Analysis). The PCA results revealed distinct difference between the patients and healthy people.

키워드

참고문헌

  1. D. J. Penn, E. Oberzaucher, K. Grammer, G. Fischer, H. A. Soini, D. Wiesler, M. V. Novotny, S. J. Dixon, Y. Xu, and R. G. Brereton, "Individual and gender fingerprints in human body odour", Journal of the Royal Society Interface, doi:10.1098, 2006.
  2. M. Phillips, J. Herrera, S. Krishnan, M. Zain, J. Greenberg, and R. N. Cataneo, "Variation in volatile organic compounds in the breath of normal humans", Journal of Chromatography B, Vol. 729, pp. 75-88, 1999. https://doi.org/10.1016/S0378-4347(99)00127-9
  3. J. W. Gardner, H. W. Shin, and E. L. Hines, "An electronic nose system to diagnose illness," Sens. Actuator B-Chem., Vol. 70, pp. 19-24, 2000. https://doi.org/10.1016/S0925-4005(00)00548-7
  4. Y. Lee, K. Song, J. Huh, W. Chung, and D. Lee, "Fabrication of clinical gas sensor using MEMS process", Sens. Actuator B-Chem., Vol. 108, pp. 292-297, 2005. https://doi.org/10.1016/j.snb.2004.12.113
  5. A. Amann, P. Spanel, and D. Smith, "Breath analysis: the approach towards clinical applications", Mini. Rev. Med. Chem., Vol. 7, No. 2, pp. 115-29, 2007. https://doi.org/10.2174/138955707779802606
  6. J.-B. Yu, H.-G. Byun, S. Zhang, S.-H. Do, J.-O. Lim, and J.-S. Huh, "Exhaled breath analysis of lung cancer patients using a metal oxide sensor", J. Sensor Sci. & Tech., Vol. 20, No. 5 pp. 300-304, 2011. https://doi.org/10.5369/JSST.2011.20.5.300
  7. C. Grote and J. Pawliszyn, "Solid-phase microextraction for the analysis of human breath", Anal. Chem. Vol. 69, pp. 587-596, 1997. https://doi.org/10.1021/ac960749l
  8. J. J. B. N. Van Berkel, J. W. Dallinga, G. M. Mo..SSller, R. W. L. Godschalk, E. J. Moonen, E. F. M. Wouters, and F. J. Van Schooten, "A profile of volatile organic compounds in breath discriminates COPD patients from controls", Respiratory Medicine, Vol. 104, pp. 557-563, 2010. https://doi.org/10.1016/j.rmed.2009.10.018
  9. C. Grote and J. Pawliszyn, "Solid-phase microextraction for the analysis of human breath", Anal. Chem., Vol. 69, pp. 587-596, 1997. https://doi.org/10.1021/ac960749l