Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Protective efficacies of Aronia melanocarpa (Blackberry) on the Allyl Alcohol-damaged Hepatocyte of Mice

쥐의 알코올성 간세포 손상에 대한 Aronia melanocapa(Blackberry)의 보호효과

  • 한상진 (한림대학교 자연과학대학 생명과학과)
  • Received : 2013.03.04
  • Accepted : 2013.03.20
  • Published : 2013.03.31
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Abstract

The results of the alcohol decomposition ability of Aronia melanocarpa are as follows. Plasma alcohol concentration of the Aronia group was ca. 48.9% lower than the control group, but half an hour faster in that of Aronia before alcohol group, ca. 54.9% higher and half an hour later than that of the control group. ALDH(acetaldehyde dehydrogenase) of the Aronia group was ca. 243% higher than that of the control group. But maximal ALDH of the group taking Aronia before alcohol administration showed 0.5h faster and ca. 267% higher than that of the control group. This result shows that the activity of ALDH was increased by the Aronia. Aronia group's AST and ALT are increasing with similar patterns and their levels continually under the control's, but ca. 12.6% lower at AST and ca. 19.0% lower at ALT than those of control group. Ca. 21.7% lower at AST and ca. 40.5% lower at ALT in the Aronia group before alcohol administration than those of the control group. This result shows that Aronia has a role of suppressor against the liver damage. Therefore, this study proved lucidly the protective effects of Aronia on the hepatocyte.

Keywords

References

  1. Kokotkiewicz, A., Jaremicz, Z. and Luczkiewicz, M. (2010) Aronia plants: A review of traditional use, biological activities, and perspectives for modern medicine. J. Med. Food. 13: 255-69. https://doi.org/10.1089/jmf.2009.0062
  2. Atringl. A. W, Leitner, E. and Pfannhauser, W. (1995) Die schwarze Apfelbeere (Aronia melanocarpa) als natuerliche Farbstoffe; Deutsche Lebensmittel Rundschau 91: 177-180.
  3. Wu, X., Gu, L., Prior, R. L. and McKay, S. (2004) Characterization of anthocyanins and proanthocyanidins in some cultivars of Ribes, Aronia, and Sambucus and their antioxidant capacity. J. Agric. Food Chem. 52: 7846-7856. https://doi.org/10.1021/jf0486850
  4. Naruszewicz, M., Laniewska, I., Millo, B. and Dluzniewski, M. (2007) Combination therapy of statin with flavonoids rich extract from chokeberry fruits enhanced reduction in cardiovascular risk markers in patients after myocardial infraction( MI). Atherosclerosis 194: 79-84.
  5. Bcuvorova, I. N., Davydov, V. V., Prozorovskii, V. N. and Shvets, V. N. (2005) Peculiarity of the antioxidant action of the extract from Aronia melanocarpa leaves antioxidant on the brain. Biomed. Khim. 51: 66-71.
  6. Kedzierska, M., Glowacki, R., Czernek, U., Szydlowska-Pazara, K., Potemski, P., Piekarski, J., Jeziorski, A. and Olas, B. (2013) Changes in plasma thiol levels induced by different phases of treatment in breast cancer; the role of commercial extract from blackchokeberry. Mol. Cell Biochem. 372: 47-55. https://doi.org/10.1007/s11010-012-1444-2
  7. Andrzj, P., Kosmider, A., Laniewska, I. and Dluzniewski, M. (2007) Flavonoid rich chokeberry fruit extract inhibits endothelial progenitor cells senescence induce by oxidized LDL. J. Clinical Lipidology 1: 86-96.
  8. Skupie, K., Kostrzewa-Nowak, D., Oszmiask, J. and Tarasiuk, J. (2008) In vitro antileukaemic activity of extracts from chokeberry (Aronia melanocarpa [Michx] Elliott) and mulberry (Morus alba L.) leaves against sensitive and multidrug resistant HL60 cells. Phytother. Res. 22: 689-694. https://doi.org/10.1002/ptr.2411
  9. Malik, M., Zhao, C., Schoene, N., Guisti, M. M., Moyer, M. P. and Magnuson, B. A. (2003) Anthocyanin-rich extract from Aronia meloncarpa E induces a cell cycle block in colon cancer but not normal colonic cells. Nutr. Cancer. 46: 186-96. https://doi.org/10.1207/S15327914NC4602_12
  10. Chrubasik, C., Li, G. and Chrubasik, S. (2010) The clinical effectiveness of chokeberry. Phytother. Res. 24: 1107-1114.
  11. Matsumoto, M., Hara, H., Chiji, H. and Kasai, T. (2004) Gastroprotective effect of red pigments in black chokeberry fruit (Aronia melanocarpa Elliot) on acute gastric hemorrhagic lesions in rats. J. Agric. Food Chem. 52: 2226-2229. https://doi.org/10.1021/jf034818q
  12. Borissova, P., Valcheva, S. and Belcheva, A. (1994) Antiinflammatory effect of flavonoids in the natural juice from Aronia melanocarpa, rutin and rutin-magnesium complex on an experimental model of inflammation induced by histamine and serotonin. Acta Physiol. Pharmacol. 20: 25-30.
  13. Simeonov, S. B., Botushanov, N. P., Karahanian, E. B., Pavlova, M. B., Husianitis. H. K. and Troev, D. M. (2002) Effects of Aronia melanocarpa juice as part of the dietary regimen in patients with diabetes mellitus. Folia Med. 44: 20-23
  14. Valcheva-Kuzmanova, S., Kuzmanov, K., Mihova, V., Krasnaliev, I., Borisova, P. and Belcheva, A. (2007) Antihyperlipidemic effect of Aronia melanocarpa fruit juice in rats fed a high-cholesterol diet. Plant Foods Hum. Nutr. 62: 19-24 https://doi.org/10.1007/s11130-006-0036-2
  15. Broncel, M., Kozirog-Ko acinska, M., Andryskowski, G., Duchnowic, Z. P., Koter-Michalak M., Owczarczyk, A. and Chojnowska-Jezierska, J. (2007) Effect of anthocyanins from Aronia melanocarpa on blood pressure, concentration of endothelin-1 and lipids in patients with metabolic syndrome. Pol. Merkur Lekarski. 23: 116-119.
  16. Khknen, M. P., Hopia, A. I. and Heinonen, M. (2001) Berry phenolics and their antioxidant activity. J. Agric. Food Chem. 49: 4076-4082. https://doi.org/10.1021/jf010152t
  17. Zheng, W. and Wang, S. Y. (2003) Oxygen Radical Absorbing Capacity of Phenolics in Blueberries, Cranberries, Chokeberries, and Lingonberries. J. Agric. Food Chem. 51: 502-509 https://doi.org/10.1021/jf020728u
  18. Krajka-Kuniak, V., Szaefer, H., Ignatowicz, E., Adamska, T., Oszmiaski, J. and Baer-Dubowska, W. (2009) Effect of Chokeberry (Aronia melanocarpa) juice on the metabolic activation and detoxication of carcinogenic N-nitrosodiethylamine in rat liver. J. Agric. Food Chem. 57: 5071-5077. https://doi.org/10.1021/jf803973y
  19. Ishii, H., Kurose, I. and Kato, S. (1997) Pathogenesis of alcoholic liver disease with particular emphasis on oxidative stress, J. Gastroenterol. Hepatol. 12: 272S-282S. https://doi.org/10.1111/j.1440-1746.1997.tb00510.x
  20. Meier, P. and Seitz, H. K. (2008) Age, alcohol metabolism and liver disease. Curr. Opin. Clin. Nutr. Metab. Care 11: 21-26 https://doi.org/10.1097/MCO.0b013e3282f30564
  21. Valcheva-Kuzmanova, S. V. and Belcheva, A. (2006) Current knowledge of Aronia melanocarpa as a medicinal plant. Folia Med. 48: 11-7.
  22. Bostian, K. A. (1977) Instrumentation for differential fluorescence spectroscopy. Anal. Biochem. 82: 353-61. https://doi.org/10.1016/0003-2697(77)90172-5
  23. 보건복지가족부(질병관리본부) (2007) 국민건강영양조사 건강행태통계(월간음주율).
  24. Lieber, C. S. (1994) Alcohol and Liver disease. Gastroenterology 160: 1085-1090.
  25. Valcheva-Kuzmanova. S., Borisova, P., Galunska, B., Krasnaliev, I. and Belcheva, A. (2004) Hepatoprotective effect of the natural fruit juice from Aronia melanocarpa on carbon tetrachloride-induced acute liver damage in rats, Exp. Toxicol. Pathol. 56: 195-201. https://doi.org/10.1016/j.etp.2004.04.012
  26. Valcheva-Kuzmanova, S. V., Popova, P. B., Galunska, B. T. and Belcheva. A. (2006) Protective effect of Aronia melanocarpa fruit juice pretreatment in a model of carbon tetrachloride- induced hepatotoxicity in rats, Folia Med, 48: 11-17
  27. Oszmianski, J. and Sepia, J. C. (1988) Anthocyanins in fruits of Aronia melanocarpa (Chokeberry), J. Food Sci. 53: 1241- 1242. https://doi.org/10.1111/j.1365-2621.1988.tb13577.x