Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Anti-Allergy and Anti-Pruritic Effects of Diospyros lotus L. Leaf Extract

고욤(Diospyros lotus L.)잎 추출물의 항알레르기 및 항가려움 효과

  • Received : 2013.02.06
  • Accepted : 2013.03.04
  • Published : 2013.03.31
Download PDF
⟨ Previous Next ⟩

Abstract

The worldwide prevalence and severity of allergic diseases including atopic and contact dermatitis has increased dramatically over the past decade, especially in developed countries. Mast cells are important effector cells in allergic reactions. The purpose of this study was undertaken to investigate the anti-allergic and anti-pruritic effects of Diospyros lotus leaf extract (DLE). DLE was prepared by extracting with distilled water. In the present study, we investigated the effect of DLE on the production of tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$), interleukin-$1{\beta}$ (IL-$1{\alpha}$) and histamine in rat peritoneal mast cells (RPMCs), and on the skin lesion, leukocyte infiltration and scratching behavior in mice. Phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187 significantly increased TNF-${\alpha}$ and IL-$1{\beta}$ production compared with media control. However, TNF-${\alpha}$ and IL-6 production increased by PMA plus A23187 treatment were significantly inhibited by DLE in a dose-dependent manner. DLE also inhibited the histamine release from RPMCs stimulated by compound 48/80, which promotes histamine release. Moreover, DLE administration had an inhibitory effects on the scratching behavior induced by pruritogen (compound 48/80, histamine) in ICR mice. Furthermore, DLE inhibited the skin lesions, inflammatory and mast cells in hairless mice sensitized by 2,4-dinitrofluorobenzene (DNFB). DLE administration reduced the IL-4 and IgE production induced by DNFB sensitization in hairless mice. These results suggest that DLE has a potential use as a herb medicine for treatment against allergy and pruritus-related disease.

Keywords

References

  1. Kay, A. B. (2009) Overview of allergy and allergic diseases: with a view to the future. Br. Med. Bull. 56: 843-864.
  2. Warner, J. O., Kaliner, M. A., Crisci, C. D., Del, Giacco. S., Frew, A. J., Liu, G. H., Maspero, J., Moon, H. B., Nakagawa, T., Potter, P. C., Rosenwasser, L. J., Singh, A. B., Valovirta, E. and Van Cauwenberge, P. (2006) Allergy practice worldwide: a report by the World Allergy Organization Specialty and Training Council. Int. Arch. Allergy Immunol. 139: 166-174 https://doi.org/10.1159/000090502
  3. Takai, T. and Ikeda, S. (2011) Barrier dysfunction caused by environmental proteases in the pathogenesis of allergic diseases. Allergol. Int. 60: 25-35. https://doi.org/10.2332/allergolint.10-RAI-0273
  4. Spergel, J. M. (2010) Epidemiology of atopic dermatitis and atopic march in children. Immunol. Allergy Clin. North Am. 30: 269-280. https://doi.org/10.1016/j.iac.2010.06.003
  5. Hon, K. L., Yong, V. and Leung, T. F. (2012) Research statistics in atopic eczema: what disease is this? Ital. J. Pediatr. 38: 26. https://doi.org/10.1186/1824-7288-38-26
  6. Boguniewicz, M. and Leung, D. Y. (2010) Recent insights into atopic dermatitis and implications for management of infectious complications. J. Allergy Clin. Immunol. 125: 4-13.
  7. Vitaliti, G., Morselli, I., Di Stefano, V., Lanzafame, A., La Rosa, M. and Leonardi, S. (2012) Urticaria and anaphilaxis in a child after inhalation of lentils vapours: a case report and literature review. Ital. J. Pediatr. 38: 71. https://doi.org/10.1186/1824-7288-38-71
  8. Nakae, S., Suto, H., Kakurai, M., Sedgwick, J. D., Tsai, M. and Galli, S. J. (2005) Mast cells enhance T cell activation: importance of mast cell-derived TNF. Proc. Natl. Acad. Sci. USA. 102: 6467-6472. https://doi.org/10.1073/pnas.0501912102
  9. Galli, S. J. (1993) New concepts about the mast cell. N. Engl. J. Med. 328: 257-265. https://doi.org/10.1056/NEJM199301283280408
  10. Mekori, Y.A. and Metcalfe, D.D. (2000) Mast cells in innate immunity. Immunol. Rev. 173: 131-140. https://doi.org/10.1034/j.1600-065X.2000.917305.x
  11. Hosoda, M., Yamaya, M., Suzuki, T., Yamada, N., Kamanakam, M., Sekizawa, K., Butterfield, J. H., Watanabe, T., Nishimura, H. and Sasaki, H. (2002) Effects of rhinovirus infection on histamine and cytokine production by cell lines from human mast cells and basophils. J. Immunol. 169: 1482- 1491.
  12. Ahmet, F. A. and Kadioglu, A. (1998) Non volatile acid composition during fruit development of Diospyros lotus L. Turk. J. Bot. 22: 69-72.
  13. Ayaz, F. A., Kadioglu, A. and Hayirlioglu, S. (1995) Determination of some mono- and disaccharides in the fruits of Diospyros lotus L. using gas chromatography. Tr. J. Bot. 19: 493-495.
  14. Ayaz, F. A. and Kadioglu, A. (1999) Fatty acid compositional changes in developing Persimmon (Diospyros lotus L.) fruit. New Zealand J. Crop. Hort. Sci. 27: 257-261. https://doi.org/10.1080/01140671.1999.9514104
  15. Loizzo, M. R., Said, A., Tundis, R., Hawas, U. W., Rashed, K., Menichini, F., Frega, N.G. and Menichini, F. (2009) Antioxidant and antiproliferative activity of Diospyros lotus L. extract and isolated compounds. Plant Foods Hum. Nutr. 64: 264-270. https://doi.org/10.1007/s11130-009-0133-0
  16. Azadbakht, M., Hosseinimehr, S.J., Shokrzadeh, M., Habibi, E. and Ahmadi, A. (2011) Diospyros lotus L. fruit extract protects G6PD-deficient erythrocytes from hemolytic injury in vitro and in vivo: prevention of favism disorder. Eur. Rev. Med. Pharmacol. Sci. 15: 1270-1281.
  17. Moghaddam, A. H., Nabavi, S. M., Nabavi, S. F., Bigdellou, R., Mohammadzadeh, S. and Ebrahimzadeh, M. A. (2012) Antioxidant, antihemolytic and nephroprotective activity of aqueous extract of Diospyros lotus seeds. Acta. Pol. Pharm. 69: 687-692.
  18. Nabavi, S.M., Ebrahimzadeh, M.A., Nabavi, S.F., Fazelian, M. and Eslami, B. (2009) In vitro Antioxidant and Free Radical Scavenging Activity of Diospyros lotus and Pyrus boissieriana growing in Iran. Pharmaco. Maga. 5: 122-126.
  19. Martynova, M. G., Bystrova, O. A., Moiseeva, O. M., Evdonin, A. L., Kondratov, K. A. and Medvedeva, N. D. (2005) The presence of ANP in rat peritoneal mast cells. Cell Res. 15: 811-816. https://doi.org/10.1038/sj.cr.7290350
  20. Mihara,, K., Kuratani, K., Matsui, T., Nakamura, M. and Yokota, K. (2004) Vital role of the itch-scratch response in development of spontaneous dermatitis in NC/Nga mice. Br. J. Dermato. 151: 335-345. https://doi.org/10.1111/j.1365-2133.2004.06036.x
  21. Walsh, L. J., Trinchieri, G., Waldorf, H. A., Whitaker, D. and Murphy, G. F. (1991) Human dermal mast cells contain and release tumor necrosis factor alpha, which induces endothelial leukocyte adhesion molecule 1. Proc. Natl. Acad. Sci. USA. 88: 4220-4224. https://doi.org/10.1073/pnas.88.10.4220
  22. Dinarello, C. A. (1994) The biological properties of interleukin-1. Eur. Cytokine Netw. 5: 517-531.
  23. Benyon, R. C., Robinson, C. and Church, M. K. (1989) Differential release of histamine and eicosanoids from human skin mast cells activated by IgE-dependent and non-immunological stimuli. Br. J. Pharmacol. 97: 898-904. https://doi.org/10.1111/j.1476-5381.1989.tb12030.x
  24. Takubo, M., Ueda, Y., Yatsuzuka, R., Jiang, S., Fujii, Y. and Kamei, C. (2006) Characteristics of scratching behavior induced by some chemical mediators in hairless mice. J. Pharmacol. Sci. 100: 285-288. https://doi.org/10.1254/jphs.FPJ06002X
  25. Casset, A. and Braun, J. J. (2010) Relationships between indoor allergens, sensitization, and allergic asthma and rhinitis symptoms. Rev. Mal. Respir. 27: 913-920. https://doi.org/10.1016/j.rmr.2010.07.006