Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Antioxidant Activity and Inhibition of MMP-1 Expression of Schizandrae fructus (Schizandra chinensis) Extract

오미자 추출물의 항산화 활성 및 MMP-1 발현저해

  • 박성민 ((주)코씨드바이오팜 기술연구소) ;
  • 김진준 ((주)한국콜마 피부과학연구소) ;
  • 정관영 ((주)한국콜마 피부과학연구소) ;
  • 한상근 ((주)한국콜마 피부과학연구소) ;
  • 정태화 ((주)한국콜마 피부과학연구소) ;
  • 윤미영 (광주여자대학교 미용과학과)
  • Received : 2012.09.07
  • Accepted : 2013.03.12
  • Published : 2013.03.31
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Abstract

We invesitagat the effects of antioxidant and suppression of MMP-1 in UV-irradiated human dermal fibroblasts (HDF) by schizandrin isolated from Schisandra chinensis. Ultrasonic technique was used to extract schizandrin from S. chinensis. The higher contents of schizandrin (6.34 mg/ml) in 70% EtOH extract obtained by ultrasonic treatment at 20 MHz for 2 h during 10 days. Schizandrin had antioxidant activities. Schizandrin (1-10 ${\mu}g/ml$) induced a significant dose-dependent decrease in the expression fo MMP-1 protein. These results suggest that schizandrin is a potential candidate for the prevention and treatment of skin aging.

Keywords

References

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