Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Inhibitory Effect of Elastase and Tyrosinase of Ginsenoside $F_1$ Isolated from Panax ginseng Leaves

인삼잎으로부터 분리된 진세노사이드 $F_1$의 Elastase 및 Tyrosinase 억제 효과

  • 홍세철 ((재)금산국제인삼약초연구소) ;
  • 유남희 ((재)금산국제인삼약초연구소) ;
  • 유지현 ((재)금산국제인삼약초연구소) ;
  • 이건희 ((재)금산국제인삼약초연구소) ;
  • 김보람 ((재)금산국제인삼약초연구소) ;
  • 이호주 ((재)금산국제인삼약초연구소) ;
  • 김종민 ((재)금산국제인삼약초연구소) ;
  • 성낙술 ((재)금산국제인삼약초연구소) ;
  • 표미경 ((재)금산국제인삼약초연구소)
  • Received : 2013.01.11
  • Accepted : 2013.02.19
  • Published : 2013.03.31
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Abstract

This study was carried to establish a simple isolation and purification method of ginsenoside $F_1$ from leaves of Panax ginseng and was to evaluate the inhibitory effect of purified ginsenoside $F_1$ on the activities of elastase and tyrosinase. The content of ginsenoside $F_1$ was 90-fold higher in leaves than in root of ginseng. Ginsenoside $F_1$ was isolated from EtOAc fraction between EtOAc and alkalized water of 80% EtOH extract after remove of hydrophobic components. The 50% inhibitory concentration ($IC_{50}$) of ginsenoside $F_1$ on elastase activity and tyrosinase activity was 1.07 mM and 1.81 mM, respectively. Especially, inhibitory effect of ginsenoside $F_1$ on tyrosinase activity was higher than that of arbutin ($IC_{50}$; 2.20 mM). These results indicate that ginsenoside $F_1$ have a potential for industrial cosmetic materials.

Keywords

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